The nail matrix onychodermis – the curious reason behind the color of the lunula
Corresponding Author
Dongyoun Lee
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorTaemin Lee
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorJoonho Shim
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorJihye Park
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKyung-Hoon Lee
Department of Anatomy, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorCorresponding Author
Dongyoun Lee
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorTaemin Lee
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorJoonho Shim
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorJihye Park
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorKyung-Hoon Lee
Department of Anatomy, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Search for more papers by this authorConflict of interest: None.
Funding source: None.
References
- 1Lee DY, Park JH, Shin HT, Yang JM, Jang KT, Kwon GY, et al. The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphological and immunohistochemical study. Histopathology. 2012; 61: 123–130.
- 2Lee DY, Park JH, Li M, Abudureyimu G, Oh SJ, Shin HT, et al. The concept of nail matrix onychodermis (onychomatricodermis) in the nail unit: histology and elastin immunohistochemistry. J Cutan Pathol. 2019; 46: 490–497.
- 3Lee D, Abudureyimu G, Park JH, Jang KT, Kwon GY, Shim JS. Characterization of the onychomatricodermis containing onychofibroblasts of the nail unit: histology, immunohistochemistry, and electron microscopic study. Ann Dermatol. 2021; 33: 108–115.
- 4Kim HJ, Shim JH, Park JH, Shin HT, Shim JS, Jang KT, et al. Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Commun Biol. 2021; 4: 692.
- 5Perrin C, Coutts M. Concept of onychodermis has no microanatomical basis. Histopathology. 2023. https://doi.org/10.1111/his.15089
- 6Park JH, Lee DY, Jang KT, Ha SY, Kwon GY, Lee KH, et al. CD13 is a marker for onychofibroblasts within nail matrix onychodermis: comparison of its expression patterns in the nail unit and in the hair follicle. J Cutan Pathol. 2017; 44: 909–914.
- 7Shim J, Park J, Abudureyimu G, Kim MH, Shim JS, Jang KT, et al. Comparative spatial transcriptomic and single-cell analyses of human nail units and hair follicles show transcriptional similarities between the onychodermis and follicular dermal papilla. J Invest Dermatol. 2022; 142: 3146–3157.
- 8Drapé JL, Wolfram-Gabel W, Idy-Peretti I, Baran R, Goettmann S, Sick H, et al. The lunula: a magnetic resonance imagining approach to the subnail matrix area. J Invest Dermatol. 1996; 106: 1081–1085.
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