Primary mucinous ovarian neoplasms rarely show germ cell histogenesis
Felix K F Kommoss
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
Search for more papers by this authorDane Cheasley
Peter MacCallum Cancer Centre, Melbourne, Australia
Search for more papers by this authorMatthew J Wakefield
Walter and Eliza Hall Institute, Parkville, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorClare L Scott
Peter MacCallum Cancer Centre, Melbourne, Australia
Walter and Eliza Hall Institute, Parkville, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorIan G Campbell
Peter MacCallum Cancer Centre, Melbourne, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorC Blake Gilks
Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
Search for more papers by this authorKylie Gorringe
Peter MacCallum Cancer Centre, Melbourne, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorFelix K F Kommoss
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
Search for more papers by this authorDane Cheasley
Peter MacCallum Cancer Centre, Melbourne, Australia
Search for more papers by this authorMatthew J Wakefield
Walter and Eliza Hall Institute, Parkville, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorClare L Scott
Peter MacCallum Cancer Centre, Melbourne, Australia
Walter and Eliza Hall Institute, Parkville, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorIan G Campbell
Peter MacCallum Cancer Centre, Melbourne, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorC Blake Gilks
Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada
Search for more papers by this authorKylie Gorringe
Peter MacCallum Cancer Centre, Melbourne, Australia
University of Melbourne, Parkville, Australia
Search for more papers by this authorConflict of interest
The authors declare no conflicts of interest.
References
- 1Cheasley D, Wakefield MJ, Ryland GL et al. The molecular origin and taxonomy of mucinous ovarian carcinoma. Nat. Commun. 2019; 10; 3935.
- 2Seidman JD, Khedmati F. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with Walthard cell nests: a study of 120 tumors. Arch. Pathol. Lab. Med. 2008; 132; 1753–1760.
- 3Kerr SE, Flotte AB, McFalls MJ, Vrana JA, Halling KC, Bell DA. Matching maternal isodisomy in mucinous carcinomas and associated ovarian teratomas provides evidence of germ cell derivation for some mucinous ovarian tumors. Am. J. Surg. Pathol. 2013; 37; 1229–1235.
- 4Heskett MB, Sanborn JZ, Boniface C et al. Multiregion exome sequencing of ovarian immature teratomas reveals 2N near-diploid genomes, paucity of somatic mutations, and extensive allelic imbalances shared across mature, immature, and disseminated components. Mod. Pathol. 2020; 33; 1193–1206.
- 5Deka R, Chakravarti A, Surti U et al. Genetics and biology of human ovarian teratomas. II. Molecular analysis of origin of nondisjunction and gene-centromere mapping of chromosome I markers. Am. J. Hum. Genet. 1990; 47; 644–655.
- 6Surti U, Hoffner L, Chakravarti A, Ferrell RE. Genetics and biology of human ovarian teratomas. I. Cytogenetic analysis and mechanism of origin. Am. J. Hum. Genet. 1990; 47; 635–643.
- 7Gorringe KL, Cheasley D, Wakefield MJ et al. Therapeutic options for mucinous ovarian carcinoma. Gynecol. Oncol. 2020; 156; 552–560.
- 8Clement PB, Young RH. Monodermal teratoma. Curr. Diagn. Pathol. 1995; 2; 214–221.
10.1016/S0968-6053(05)80021-3 Google Scholar
- 9Cooke SL, Ennis D, Evers L et al. The driver mutational landscape of ovarian squamous cell carcinomas arising in mature cystic teratoma. Clin. Cancer Res. 2017; 23; 7633–7640.