Volume 64, Issue 5 pp. 647-659

Original Article

Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma

Sun Young Kwon,

Sun Young Kwon

Department of Pathology, Keimyung University School of Medicine, Daegu, Korea

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Young Kyung Bae,

Corresponding Author

Young Kyung Bae

Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea

Address for correspondence: Y K Bae, Department of Pathology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 705-717, Korea. e-mail: [email protected]Search for more papers by this author

Mi Jin Gu,

Mi Jin Gu

Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea

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Jung Eun Choi,

Jung Eun Choi

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

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Su Hwan Kang,

Su Hwan Kang

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

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Soo Jung Lee,

Soo Jung Lee

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

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Aeri Kim,

Aeri Kim

Department of Pathology, Daegu Fatima Hospital, Daegu, Korea

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Hye Ra Jung,

Hye Ra Jung

Department of Pathology, Keimyung University School of Medicine, Daegu, Korea

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Sun Hee Kang,

Sun Hee Kang

Department of Surgery, Keimyung University School of Medicine, Daegu, Korea

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Hoon Kyu Oh,

Hoon Kyu Oh

Department of Pathology, Daegu Catholic University College of Medicine, Daegu, Korea

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Ji Young Park,

Ji Young Park

Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea

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Sun Young Kwon,

Sun Young Kwon

Department of Pathology, Keimyung University School of Medicine, Daegu, Korea

Search for more papers by this author

Young Kyung Bae,

Corresponding Author

Young Kyung Bae

Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea

Mi Jin Gu,

Mi Jin Gu

Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea

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Jung Eun Choi,

Jung Eun Choi

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

Search for more papers by this author

Su Hwan Kang,

Su Hwan Kang

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

Search for more papers by this author

Soo Jung Lee,

Soo Jung Lee

Department of Surgery, Yeungnam University College of Medicine, Daegu, Korea

Search for more papers by this author

Aeri Kim,

Aeri Kim

Department of Pathology, Daegu Fatima Hospital, Daegu, Korea

Search for more papers by this author

Hye Ra Jung,

Hye Ra Jung

Department of Pathology, Keimyung University School of Medicine, Daegu, Korea

Search for more papers by this author

Sun Hee Kang,

Sun Hee Kang

Department of Surgery, Keimyung University School of Medicine, Daegu, Korea

Search for more papers by this author

Hoon Kyu Oh,

Hoon Kyu Oh

Department of Pathology, Daegu Catholic University College of Medicine, Daegu, Korea

Search for more papers by this author

Ji Young Park,

Ji Young Park

Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea

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First published: 09 October 2013

https://doi.org/10.1111/his.12306

Citations: 51

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Abstract

Aims

Invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence and clinical significance of NE differentiation in patients with IBC.

Methods and results

We performed immunohistochemistry for NE markers, chromogranin-A and synaptophysin on 1428 IBC samples using tissue microarrays and classified cases with NE differentiation into two groups, focal (1–49% tumour cells positive for any NE marker) and diffuse (≥50% tumour cells positive) groups. Fifty-nine cases (4.1%) showed NE differentiation immunohistochemically, and the majority did not show typical NE morphology. The presence of NE differentiation showed a significant association with positive oestrogen receptor (P = 0.001) and progesterone receptor (P = 0.008) status. Patients with NE differentiation showed worse overall survival (OS) and disease-free survival (DFS) than those without NE differentiation in both univariate (P < 0.001 for both) and multivariate (OS, P = 0.004; DFS, P < 0.001) analyses.

Conclusions

IBC with NE differentiation is a distinct subtype of mammary carcinoma with an aggressive clinical outcome.

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Volume64, Issue5

April 2014

Pages 647-659

Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma

Abstract

Aims

Methods and results

Conclusions

References

Citing Literature

References

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Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma

Abstract

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Methods and results

Conclusions

References

Citing Literature

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