The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle-aged to older adults in west China: a cross-sectional study
Xuelian Sun
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Conceptualization (lead), Formal analysis (equal), Writing - original draft (lead), Writing - review & editing (equal)
Search for more papers by this authorKiyana Elizabeth Harris
Philadelphia College of Osteopathic Medicine, Duluth, Georgia, USA
Contribution: Conceptualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorLisha Hou
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Supervision (equal)
Search for more papers by this authorXin Xia
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Resources (equal)
Search for more papers by this authorXiaolei Liu
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorMeiling Ge
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorShuli Jia
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (supporting), Methodology (supporting), Software (equal)
Search for more papers by this authorLixing Zhou
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Funding acquisition (equal), Investigation (equal), Methodology (equal)
Search for more papers by this authorWanyu Zhao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorYan Zhang
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Resources (equal), Software (equal)
Search for more papers by this authorYunli Zhao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (supporting), Software (supporting)
Search for more papers by this authorYang Mei
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Formal analysis (equal), Investigation (equal)
Search for more papers by this authorGongchang Zhang
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Resources (equal), Software (equal)
Search for more papers by this authorLiuyi Xin
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorQiukui Hao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorYanjiao Shen
Department of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (supporting)
Search for more papers by this authorChun Xiao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorJirong Yue
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Supervision (equal)
Search for more papers by this authorNing Ge
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal)
Search for more papers by this authorYing Li
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal)
Search for more papers by this authorCorresponding Author
Birong Dong
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Birong Dong, National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Qianli Xue, Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Email: [email protected]
Contribution: Conceptualization (equal), Funding acquisition (equal), Investigation (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Qianli Xue
Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Correspondence
Birong Dong, National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Qianli Xue, Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Email: [email protected]
Contribution: Conceptualization (equal), Formal analysis (equal), Funding acquisition (equal), Methodology (equal), Project administration (equal), Supervision (equal), Validation (equal), Writing - review & editing (equal)
Search for more papers by this authorXuelian Sun
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Conceptualization (lead), Formal analysis (equal), Writing - original draft (lead), Writing - review & editing (equal)
Search for more papers by this authorKiyana Elizabeth Harris
Philadelphia College of Osteopathic Medicine, Duluth, Georgia, USA
Contribution: Conceptualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorLisha Hou
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Supervision (equal)
Search for more papers by this authorXin Xia
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Resources (equal)
Search for more papers by this authorXiaolei Liu
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorMeiling Ge
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorShuli Jia
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (supporting), Methodology (supporting), Software (equal)
Search for more papers by this authorLixing Zhou
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Funding acquisition (equal), Investigation (equal), Methodology (equal)
Search for more papers by this authorWanyu Zhao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Methodology (equal), Software (equal)
Search for more papers by this authorYan Zhang
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Resources (equal), Software (equal)
Search for more papers by this authorYunli Zhao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (supporting), Software (supporting)
Search for more papers by this authorYang Mei
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Formal analysis (equal), Investigation (equal)
Search for more papers by this authorGongchang Zhang
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Resources (equal), Software (equal)
Search for more papers by this authorLiuyi Xin
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Investigation (equal), Writing - review & editing (equal)
Search for more papers by this authorQiukui Hao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorYanjiao Shen
Department of Guideline and Rapid Recommendation, Cochrane China Centre, MAGIC China Centre, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (supporting)
Search for more papers by this authorChun Xiao
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Writing - review & editing (equal)
Search for more papers by this authorJirong Yue
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal), Project administration (equal), Supervision (equal)
Search for more papers by this authorNing Ge
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal)
Search for more papers by this authorYing Li
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Contribution: Methodology (equal)
Search for more papers by this authorCorresponding Author
Birong Dong
National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China
Correspondence
Birong Dong, National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Qianli Xue, Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Email: [email protected]
Contribution: Conceptualization (equal), Funding acquisition (equal), Investigation (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal)
Search for more papers by this authorCorresponding Author
Qianli Xue
Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Correspondence
Birong Dong, National Clinical Research Center of Geriatrics and Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, Sichuan 610041, China.
Email: [email protected]
Qianli Xue, Departments of Medicine, Biostatistics, and Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA.
Email: [email protected]
Contribution: Conceptualization (equal), Formal analysis (equal), Funding acquisition (equal), Methodology (equal), Project administration (equal), Supervision (equal), Validation (equal), Writing - review & editing (equal)
Search for more papers by this authorFunding information
This work was supported by 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZY2017201); Establishment of Non-pharmacological Intervention System for the Behavioral and Psychological Syndrome of the Older Adults with Dementia (ZX2019023); National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Z20201005); the National Natural Science Foundation of China (No. 81901411); the National Institute on Aging (T35AG026758); Horizontal project of West China Hospital, Sichuan University (HX-H2004062). The financial sponsors had no role in the design, implementation, analyses or reporting of the results
Abstract
Background and purpose
Motoric cognitive risk (MCR) syndrome characterized by subjective cognitive complaints and slow gait has been proposed and validated as a pre-dementia syndrome. The overall and specific ethnic prevalence of MCR and the associated factors are poorly understood in middle-aged to older community-dwelling residents in west China.
Methods
The present study included 6091 samples from the prospective cohort study, West China Health and Aging Trend (WCHAT). Multidimensional factors of demography, lifestyle, social support, anthropometrics and body components, and clinical status were investigated and analyzed by univariate and multivariate logistic regression models. Lasso regression and K-fold cross-validation were conducted to construct the most predictive model with fitted factors.
Results
The overall prevalence of MCR was 9.74%, and ethnically the prevalence was 14.25% in Tibetan, 11.03% in Yi, 10.72% in Han, 5.18% in Uighur and 4.55% in Qiang, respectively. In the adjusted models, the positively associated risk factors included diabetes mellitus (odds ratio [OR] = 1.51, p = 0.007), osteoarthritis (OR = 1.50, p = 0.002), depression (OR = 1.36, p = 0.005), poor sleep (OR = 1.21, p = 0.045), comorbidity (OR = 1.49, p = 0.001) and falls in the last 12 months (OR = 1.34, p = 0.031). Of note, every 1-unit increase of value in stroke was associated with an approximate 3-fold higher risk of having MCR, whilst in high-density lipoprotein with a 30% lower risk of MCR,respectively.
Conclusions
Profiles of MCR from the aspects of ethnicity and the presenium stage need further exploration. It is a promising strategy to apply MCR as a primary prevention tool to prevent dementia.
CONFLICT OF INTERESTS
The authors declare no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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