Volume 28, Issue 6 pp. 1992-1999

ORIGINAL ARTICLE

Apolipoprotein E genotype predicts subarachnoid extension in spontaneous intracerebral haemorrhage

Xiaodong Ye

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Software (equal), Visualization (equal), Writing - original draft (equal)

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Guo Li,

Guo Li

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Formal analysis (equal), Investigation (equal), Methodology (equal), Software (equal), Validation (equal), Visualization (equal)

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Xiaoyan Liu,

Xiaoyan Liu

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Investigation (equal), Project administration (equal), Supervision (equal), Validation (equal)

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Guini Song,

Guini Song

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Yuchao Jia,

Yuchao Jia

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Chunmei Wu,

Chunmei Wu

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Xiong Wang,

Xiong Wang

Department of Laboratory Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal)

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Shanshan Huang,

Corresponding Author

Shanshan Huang

[email protected]

orcid.org/0000-0003-1394-3481

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence

Shanshan Huang and Suiqiang Zhu, Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Hankou, Wuhan 430030, China.

Email: [email protected] (S.H.); [email protected] (S.Z.)

Contribution: Conceptualization (equal), Funding acquisition (equal), Project administration (equal), Resources (equal), Supervision (equal), Writing - original draft (equal), Writing - review & editing (supporting)

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Suiqiang Zhu,

Corresponding Author

Suiqiang Zhu

[email protected]

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence

Email: [email protected] (S.H.); [email protected] (S.Z.)

Contribution: Conceptualization (equal), Funding acquisition (equal), Project administration (equal), Resources (equal), Supervision (equal), Writing - review & editing (lead)

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Xiaodong Ye,

Xiaodong Ye

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Guo Li,

Guo Li

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Formal analysis (equal), Investigation (equal), Methodology (equal), Software (equal), Validation (equal), Visualization (equal)

Search for more papers by this author

Xiaoyan Liu,

Xiaoyan Liu

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Investigation (equal), Project administration (equal), Supervision (equal), Validation (equal)

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Guini Song,

Guini Song

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Yuchao Jia,

Yuchao Jia

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Chunmei Wu,

Chunmei Wu

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal), Software (equal)

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Xiong Wang,

Xiong Wang

Department of Laboratory Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Contribution: Data curation (equal), Investigation (equal)

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Shanshan Huang,

Corresponding Author

Shanshan Huang

[email protected]

orcid.org/0000-0003-1394-3481

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence

Email: [email protected] (S.H.); [email protected] (S.Z.)

Search for more papers by this author

Suiqiang Zhu,

Corresponding Author

Suiqiang Zhu

[email protected]

Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence

Email: [email protected] (S.H.); [email protected] (S.Z.)

Contribution: Conceptualization (equal), Funding acquisition (equal), Project administration (equal), Resources (equal), Supervision (equal), Writing - review & editing (lead)

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First published: 19 March 2021

https://doi.org/10.1111/ene.14830

Citations: 6

Funding information

This work was financially supported by Hubei Technological Innovation Special Fund (CN) (Grant no. 2019ACA132), the Fundamental Research Funds for the Central Universities (Grant no. 2019kfyXKJC075) and the National Key R&D Program of China (Grant no. 2017YFC1310000).

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Abstract

Background and purpose

Spontaneous intracerebral haemorrhage (ICH) with subarachnoid extension (SAHE) predicts poor outcomes and haematoma expansion in spontaneous ICH and is also a potential predictor of the severity of vascular amyloid deposition. The biological underpinnings of SAHE remain elusive. A study was conducted to identify risk factors associated with SAHE.

Methods

A retrospective analysis was performed of an ongoing prospective cohort of primary spontaneous supratentorial ICH patients admitted to Tongji Hospital. SAHE was rated on baseline noncontrast computed tomography images by investigators blinded to the clinical data.

Results

A total of 189 patients were enrolled. Apolipoprotein E (APOE) ε2 copies (p = 0.020), but not APOE ε4 copies (p > 0.2), were more common in patients with SAHE in univariate analysis. After controlling for confounding factors in multiple logistic regression, lobar haematoma (odds ratio [OR] 14.21, 95% confidence interval [CI] 5.89–34.33; p < 0.001), large haematoma volume (OR 1.04, 95% CI 1.02–1.06; p < 0.001) and APOE ε2 copies (OR 3.07, 95% CI 1.05–8.97; p = 0.041) were three independent predictors of SAHE. For subgroup analysis stratified by location, APOE ε2 showed a possible association with SAHE in lobar ICH (p = 0.026) but not in deep ICH (p > 0.2). No significant association was found between APOE ε4 copies and either lobar (p > 0.2) or deep ICH (p > 0.2).

Conclusions

The APOE ε2 allele predicts SAHE in spontaneous supratentorial ICH. The association may predominantly apply to lobar ICH. Given the established relationship between the APOE ε2 allele and pathological cerebrovascular changes, our findings suggest that SAHE involves genetically driven vessel pathology.

CONFLICT OF INTEREST

No authors have anything to declare.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Supporting Information

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Citing Literature

Volume28, Issue6

June 2021

Pages 1992-1999

Apolipoprotein E genotype predicts subarachnoid extension in spontaneous intracerebral haemorrhage

Abstract

Background and purpose

Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

Citing Literature

References

Information

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Apolipoprotein E genotype predicts subarachnoid extension in spontaneous intracerebral haemorrhage

Abstract

Background and purpose

Methods

Results

Conclusions

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

Supporting Information

REFERENCES

Citing Literature

References

Related

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