Original Article

Evaluation of the recombinant tissue plasminogen activator pretreatment in acute stroke patients with large vessel occlusions treated with the direct bridging approach. Is it worth the effort?

Corresponding Author

L. Fjetland

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

Neuroscience Research Group, Stavanger University Hospital, Stavanger, Norway

Correspondence: L. Fjetland, Department of Radiology, Stavanger University Hospital, Postboks 8100, N-4068 Stavanger, Norway (tel.: +47 482 97 814; fax: +47 51 51 99 04; e-mail: [email protected]).Search for more papers by this author

K. D. Kurz,

K. D. Kurz

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

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S. Roy,

S. Roy

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

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M. W. Kurz,

M. W. Kurz

Neuroscience Research Group, Stavanger University Hospital, Stavanger, Norway

Department of Neurology, Stavanger University Hospital, Stavanger, Norway

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L. Fjetland,

Corresponding Author

L. Fjetland

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

Neuroscience Research Group, Stavanger University Hospital, Stavanger, Norway

K. D. Kurz,

K. D. Kurz

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

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S. Roy,

S. Roy

Department of Radiology, Stavanger University Hospital, Stavanger, Norway

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M. W. Kurz,

M. W. Kurz

Neuroscience Research Group, Stavanger University Hospital, Stavanger, Norway

Department of Neurology, Stavanger University Hospital, Stavanger, Norway

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First published: 25 September 2014

https://doi.org/10.1111/ene.12569

Citations: 11

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Abstract

Background and purpose

The direct bridging concept in acute stroke treatment combines intravenous thrombolysis (IVT) and endovascular treatment (EVT). The frequency and extent of reperfusion obtained already due to IVT were evaluated. Additionally undesired events and the clinical outcome were analysed.

Methods

Fifty-seven acute stroke patients treated with direct bridging were analysed for this study. The response to IVT was evaluated according to the modified Thrombolysis in Cerebral Infarction scale (m-TICI). IVT responders (m-TICI ≥2B in digital subtraction angiography) were compared with IVT non-responders (m-TICI <2B in digital subtraction angiography) with respect to clinical outcome and occurrence of undesired events.

Results

Fourteen patients (25%) got a change from TICI 0 to ≥2B due to IVT alone. There were otherwise no differences between the IVT responders and IVT non-responders.

Conclusions

Intravenous thrombolysis pretreatment in the context of the bridging approach contributes substantially to revascularization.

References

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Volume22, Issue2

February 2015

Pages 322-327

Evaluation of the recombinant tissue plasminogen activator pretreatment in acute stroke patients with large vessel occlusions treated with the direct bridging approach. Is it worth the effort?

Abstract

Background and purpose

Methods

Results

Conclusions

References

Citing Literature

References

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Evaluation of the recombinant tissue plasminogen activator pretreatment in acute stroke patients with large vessel occlusions treated with the direct bridging approach. Is it worth the effort?

Abstract

Background and purpose

Methods

Results

Conclusions

References

Citing Literature

References

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