Short Communication

Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease

M. Fabbri

IRCCS Institute of Neurological Science, Bologna, Italy

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

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L. C. Guedes,

L. C. Guedes

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

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M. Coelho,

M. Coelho

orcid.org/0000-0002-4008-8110

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

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D. Simão,

D. Simão

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

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D. Abreu,

D. Abreu

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

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M. M. Rosa,

M. M. Rosa

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

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L. Silveira-Moriyama,

L. Silveira-Moriyama

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK

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J. J. Ferreira,

Corresponding Author

J. J. Ferreira

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Correspondence: J. Ferreira, Neurological Clinic Research Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Av. Prof Egas Moniz, 1649-035 Lisbon, Portugal (tel.: +351 21 7973453; fax: +351 21 7802129; e-mail: [email protected]).Search for more papers by this author

M. Fabbri,

M. Fabbri

IRCCS Institute of Neurological Science, Bologna, Italy

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

L. C. Guedes,

L. C. Guedes

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

M. Coelho,

M. Coelho

orcid.org/0000-0002-4008-8110

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

D. Simão,

D. Simão

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

D. Abreu,

D. Abreu

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

M. M. Rosa,

M. M. Rosa

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

Search for more papers by this author

L. Silveira-Moriyama,

L. Silveira-Moriyama

Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK

Search for more papers by this author

J. J. Ferreira,

Corresponding Author

J. J. Ferreira

Clinical Pharmacology Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Neurological Clinic Research Unit, Faculty of Medicine, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal

Laboratory of Clinical Pharmacology and Therapeutics, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

First published: 06 March 2014

https://doi.org/10.1111/ene.12396

Citations: 17

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Abstract

Background and purpose

Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients.

Methods

Fifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification.

Results

No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients.

Conclusions

Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.

References

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Volume22, Issue1

January 2015

Pages 207-210

Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease

Abstract

Background and purpose

Methods

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Conclusions

References

Citing Literature

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Subthalamic deep brain stimulation effects on odor identification in Parkinson's disease

Abstract

Background and purpose

Methods

Results

Conclusions

References

Citing Literature

References

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