Individual factors influencing the duration of untreated psychosis
Lama Souaiby
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Department of Psychiatry, Saint Joseph University, Beirut, Lebanon
Present address Lama Souaiby, National Mental Health Program, Ministry of Public Health, Beirut, Lebanon.Search for more papers by this authorClaire Gauthier
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorMathilde Kazes
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorCélia Mam-Lam-Fook
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorClaire Daban
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorMarion Plaze
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorRaphaël Gaillard
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorthe ICAAR study group
Search for more papers by this authorCorresponding Author
Marie-Odile Krebs
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Correspondence
Marie-Odile Krebs, Centre Hospitalier Sainte-Anne, Department of Psychiatry, Service Hospitalo-Universitaire, 1, rue Cabanis, 75014 Paris, France.
Email: [email protected]
Search for more papers by this authorLama Souaiby
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Department of Psychiatry, Saint Joseph University, Beirut, Lebanon
Present address Lama Souaiby, National Mental Health Program, Ministry of Public Health, Beirut, Lebanon.Search for more papers by this authorClaire Gauthier
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorMathilde Kazes
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorCélia Mam-Lam-Fook
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorClaire Daban
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorMarion Plaze
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorRaphaël Gaillard
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Search for more papers by this authorthe ICAAR study group
Search for more papers by this authorCorresponding Author
Marie-Odile Krebs
Centre Hospitalier Sainte - Anne, Faculty of Medicine Paris Descartes, Service Hospitalo-Universitaire, Paris, France
Université Paris Descartes, INSERM UMR S894, Centre de Psychiatrie et Neurosciences, Laboratoire de Physiopathologie des Maladies Psychiatriques, Paris, France
CNRS GDR3557, Institut de Psychiatrie, France
Correspondence
Marie-Odile Krebs, Centre Hospitalier Sainte-Anne, Department of Psychiatry, Service Hospitalo-Universitaire, 1, rue Cabanis, 75014 Paris, France.
Email: [email protected]
Search for more papers by this authorAbstract
Aim
Duration of untreated psychosis (DUP), or the time between onset of psychosis and treatment initiation, is a prognostic factor of schizophrenia. However, few studies evaluated the relative influence of individual-related factors on this duration. The objective of this study was to evaluate the influence of socio-demographic, clinical and cannabis use on DUP.
Methods
This study was part of a large prospective study in help-seeking individuals referred to our specialized early detection / intervention clinic in the Service Hospitalo-Universitaire of Sainte-Anne Hospital in Paris (ICAAR study). We explored 33 consecutive patients who crossed the CAARMS' threshold of psychosis. The DUP and cannabis consumption history were explored during the baseline comprehensive assessment using all available sources (direct interviews of patients, parents, practitioners). Correlations between socio-demographic, clinical and cannabis use, and DUP were studied. A multiple linear regression model was used to determine the variables that could significantly predict DUP.
Results
When considered individually, none of the socio-demographic and disease characteristic factors was associated with DUP, with the exception of level of education. In the multivariate analysis, age at inclusion, negative symptoms and history of cannabis use significantly influenced DUP.
Conclusion
The determinants of DUP are multi-factorial and include individual centred factors, such as age, cannabis and negative symptoms. The identification of factors resulting in delayed access to care may promote the development of effective strategies to reduce DUP in early psychosis and target effective early intervention.
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