Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome
Ming-Han Mu
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Ming-Han Mu and Yi-Ning Wang authors contributed equally to this work.Search for more papers by this authorYi-Ning Wang
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Ming-Han Mu and Yi-Ning Wang authors contributed equally to this work.Search for more papers by this authorYu Huang
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorXue-Li Niu
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorHong-Duo Chen
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorCorresponding Author
Xing-Hua Gao
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Correspondence
Xing-Hua Gao and Rui-Qun Qi, Ministry of Education Key Laboratory of Immunodermatology (China Medical University), The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110001, P.R. China.
Emails: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Rui-Qun Qi
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Correspondence
Xing-Hua Gao and Rui-Qun Qi, Ministry of Education Key Laboratory of Immunodermatology (China Medical University), The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110001, P.R. China.
Emails: [email protected]; [email protected]
Search for more papers by this authorMing-Han Mu
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Ming-Han Mu and Yi-Ning Wang authors contributed equally to this work.Search for more papers by this authorYi-Ning Wang
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Ming-Han Mu and Yi-Ning Wang authors contributed equally to this work.Search for more papers by this authorYu Huang
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorXue-Li Niu
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorHong-Duo Chen
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Search for more papers by this authorCorresponding Author
Xing-Hua Gao
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Correspondence
Xing-Hua Gao and Rui-Qun Qi, Ministry of Education Key Laboratory of Immunodermatology (China Medical University), The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110001, P.R. China.
Emails: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Rui-Qun Qi
Department of dermatology, NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University) The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning, P.R. China
Correspondence
Xing-Hua Gao and Rui-Qun Qi, Ministry of Education Key Laboratory of Immunodermatology (China Medical University), The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning 110001, P.R. China.
Emails: [email protected]; [email protected]
Search for more papers by this authorFunding information National Natural Science Foundation of China, Grant/Award Number: 81673070, 81872538
Abstract
A female Cushing's syndrome patient had been suffering from extensive viral warts for months. She was diagnosed with flat warts, common warts and plantar warts. The plantar warts on her right foot were initially treated using local hyperthermia at 44°C for 30 min according to a defined protocol, followed by treatment targeting a common wart on her left thumb. In response to hyperthermia, the flat warts on her eyelid dissipated within 12 weeks, and when combined with a 1 week administration of imiquimod, the common warts and plantar warts completely disappeared within 8 weeks. There were no signs of recurrence and during this treatment her Cushing's syndrome was alleviated. This pioneer trial suggests that local hyperthermia may serve as an effective mean for treating multiple cutaneous warts under the conditions of a systemic immuno-compromised disease.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
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