Volume 37, Issue 9 pp. 1509-1518

Research: Educational and Psychological Aspects

Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes: the ADDITION-Europe trial

E.-M. Dalsgaard,

Corresponding Author

E.-M. Dalsgaard

[email protected]

orcid.org/0000-0003-2115-7480

Department of Public Health, Aarhus University, Aarhus, Denmark

Steno Diabetes Centre, Aarhus, Denmark

Correspondence to: Else-Marie Dalsgaard. E-mail: [email protected]

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A. Sandbæk,

A. Sandbæk

Department of Public Health, Aarhus University, Aarhus, Denmark

Steno Diabetes Centre, Aarhus, Denmark

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S. J. Griffin,

S. J. Griffin

MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK

Primary Care Unit, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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G. E. H. M. Rutten,

G. E. H. M. Rutten

Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht University, Utrecht, The Netherlands

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K. Khunti,

K. Khunti

orcid.org/0000-0003-2343-7099

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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M. J. Davies,

M. J. Davies

orcid.org/0000-0002-9987-9371

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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G. J. Irving,

G. J. Irving

Primary Care Unit, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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R. C. Vos,

R. C. Vos

Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht University, Utrecht, The Netherlands

Department of Public Health and Primary Care/LUMC-Campus The Hague, Leiden University Medical Centre, Leiden, The Netherlands

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D. R. Webb,

D. R. Webb

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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N. J. Wareham,

N. J. Wareham

MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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D. R. Witte,

D. R. Witte

Department of Public Health, Aarhus University, Aarhus, Denmark

Danish Diabetes Academy, Odense, Denmark

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E.-M. Dalsgaard,

Corresponding Author

E.-M. Dalsgaard

[email protected]

orcid.org/0000-0003-2115-7480

Department of Public Health, Aarhus University, Aarhus, Denmark

Steno Diabetes Centre, Aarhus, Denmark

Correspondence to: Else-Marie Dalsgaard. E-mail: [email protected]

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A. Sandbæk,

A. Sandbæk

Department of Public Health, Aarhus University, Aarhus, Denmark

Steno Diabetes Centre, Aarhus, Denmark

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S. J. Griffin,

S. J. Griffin

MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK

Primary Care Unit, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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G. E. H. M. Rutten,

G. E. H. M. Rutten

Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht University, Utrecht, The Netherlands

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K. Khunti,

K. Khunti

orcid.org/0000-0003-2343-7099

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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M. J. Davies,

M. J. Davies

orcid.org/0000-0002-9987-9371

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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G. J. Irving,

G. J. Irving

Primary Care Unit, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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R. C. Vos,

R. C. Vos

Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht University, Utrecht, The Netherlands

Department of Public Health and Primary Care/LUMC-Campus The Hague, Leiden University Medical Centre, Leiden, The Netherlands

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D. R. Webb,

D. R. Webb

Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK

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N. J. Wareham,

N. J. Wareham

MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK

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D. R. Witte,

D. R. Witte

Department of Public Health, Aarhus University, Aarhus, Denmark

Danish Diabetes Academy, Odense, Denmark

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First published: 12 June 2020

https://doi.org/10.1111/dme.14342

Citations: 1

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Abstract

Aims

To present the longer-term impact of multifactorial treatment of type 2 diabetes on self-reported health status, diabetes-specific quality of life, and diabetes treatment satisfaction at 10-year follow up of the ADDITION-Europe trial.

Methods

The ADDITION-Europe trial enrolled 3057 individuals with screen-detected type 2 diabetes from four centres [Denmark, the UK (Cambridge and Leicester) and the Netherlands], between 2001 and 2006. Participants were randomized at general practice level to intensive treatment or to routine care . The trial ended in 2009 and a 10-year follow-up was performed at the end of 2014. We measured self-reported health status (36-item Short-Form Health Survey and EQ-5D), diabetes-specific quality of life (Audit of Diabetes-Dependent Quality of Life questionnaire), and diabetes treatment satisfaction (Diabetes Treatment Satisfaction Questionnaire) at different time points during the study period. A mixed-effects model was applied to estimate the effect of intensive treatment (intention-to-treat analyses) on patient-reported outcome measures for each centre. Centre-specific estimates were pooled using a fixed effects meta-analysis.

Results

There was no difference in patient-reported outcome measures between the routine care and intensive treatment arms in this 10-year follow-up study [EQ-5D: –0.01 (95% CI –0.03, 0.01); Physical Composite Score (36-item Short-Form Health Survey): –0.27 (95% CI –1.11, 0.57), Audit of Diabetes-Dependent Quality of Life questionnaire: –0.01 (95% CI –0.11, 0.10); and Diabetes Treatment Satisfaction Questionnaire: –0.20 (95% CI –0.70, 0.29)].

Conclusions

Intensive, multifactorial treatment of individuals with screen-detected type 2 diabetes did not affect self-reported health status, diabetes-specific quality of life, or diabetes treatment satisfaction at 10-year follow-up compared to routine care.

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Volume37, Issue9

September 2020

Pages 1509-1518

Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes: the ADDITION-Europe trial

Abstract

Aims

Methods

Results

Conclusions

References

Citing Literature

References

Information

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Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes: the ADDITION-Europe trial

Abstract

Aims

Methods

Results

Conclusions

References

Citing Literature

References

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