Tumor-Induced Osteomalacia Resulting from Primary Cutaneous Phosphaturic Mesenchymal Tumor: A Case and Review of the Medical Literature
Kevin H. Gardner
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorWonwoo Shon
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorAndrew L. Folpe
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorCarilyn N. Wieland
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorPeter J. Tebben
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorCorresponding Author
Christian L. Baum
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Correspondence to:
e-mail: [email protected]
Search for more papers by this authorKevin H. Gardner
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorWonwoo Shon
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorAndrew L. Folpe
Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorCarilyn N. Wieland
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorPeter J. Tebben
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota
Search for more papers by this authorCorresponding Author
Christian L. Baum
Department of Dermatology, Mayo Clinic, Rochester, Minnesota
Correspondence to:
e-mail: [email protected]
Search for more papers by this author
References
- 1Bahrami A, Weiss SW, Montgomery E, et al. RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia. Am J Surg Pathol 2009; 33: 1348.
- 2Ozawa JC, de Paiva AF, de Prospero JD, Monte O, Scalissi NM, Maeda SS. Mesenchymal tumor in the calcaneus with oncogenic osteomalacia: a case report. J Clin Oncol 2011; 29: e6.
- 3Markou A, Tsiama V, Tournis S, et al. Coexistence of tumor-induced osteomalacia and primary hyperparathyroidism. Endocr Pract 2011; 17: e144.
- 4Ogura E, Kageyama K, Fukumoto S, et al. Development of tumor-induced osteomalacia in a subcutaneous tumor, defined by venous blood sampling of fibroblast growth factor-23. Intern Med 2008; 47: 637.
- 5Oka M, Kamo T, Sasaki E, et al. A case of phosphaturic mesenchymal tumour (mixed connective tissue variant) that developed in the subcutaneous tissue of a patient with oncogenic osteomalacia and produced fibroblast growth factor 23. Br J Dermatol 2007; 157: 198.
- 6Dewitt CA, Collins MT, Cowen EW. Diffuse pain, hypophosphatemia, and a subcutaneous nodule. J Am Acad Dermatol 2007; 57: 509.
- 7Poizat F, Wojtusciszin A, Raynaud P, Maitre H, Renard ER, Baldet P. Foot tumor and diffuse pain: a case of oncogenic osteomalacia [French]. Ann Pathol 2005; 25: 134.
- 8Folpe AL, Fanburg-Smith JC, Billings SD, et al. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 2004; 28: 1.
- 9Chong WH, Molinolo AA, Chen CC, Collins MT. Tumor-induced osteomalacia. Endocr Relat Cancer 2011; 18: R53.
- 10Jonsson KB, Zahradnik R, Larsson T, et al. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med 2003; 348: 1656.
- 11Hodgson SF, Clarke BL, Tebben PJ, Mullan BP, Cooney WP 3rd, Shives TC. Oncogenic osteomalacia: localization of underlying peripheral mesenchymal tumors with use of Tc 99m sestamibi scintigraphy. Endocr Pract 2006; 12: 35.
- 12Takeuchi Y, Suzuki H, Ogura S, et al. Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia. J Clin Endocrinol Metab 2004; 89: 3979.
- 13Uramoto N, Furukawa M, Yoshizaki T. Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongue. Auris Nasus Larynx 2009; 36: 104.
- 14Clunie GP, Fox PE, Stamp TC. Four cases of acquired hypophosphataemic (‘oncogenic’) osteomalacia: problems of diagnosis, treatment and long-term management. Rheumatology (Oxford). 2000; 39: 1415.
- 15Ogose A, Hotta T, Emura I, et al. Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia. Skeletal Radiol 2001; 30: 99.
Citing Literature
