Epidermotropic secondary cutaneous involvement by relapsed angioimmunoblastic T-cell lymphoma mimicking mycosis fungoides: a case report
Ana Ponciano
Department of Pathology, Hospital General San Juan de Dios, Guatemala City, Guatemala
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorAnne de Muret
Service d'Anatomie et Cytologie Pathologiques, Hôpital Trousseau, CHRU de Tours, 37004 Tours Cedex 9, France
Search for more papers by this authorLaurent Machet
Service de Dermatologie, Hôpital Trousseau, CHRU de Tours, 37004 Tours Cedex 9, France
Search for more papers by this authorEmmanuel Gyan
Service d'Hématologie et Thérapie Cellulaire, Hôpital Bretonneau, 37000 Tours, France
Search for more papers by this authorChristophe Monegier du Sorbier
Centre de Pathologie Origet, 3 boulevard Alfred Nobel, 37540 Sant-Cyr-sur-Loire, France
Search for more papers by this authorValérie Molinier-Frenkel
AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service d'Immunologie Biologique, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorPhilippe Gaulard
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorCorresponding Author
Nicolas Ortonne
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Nicolas Ortonne
Department of Pathology,
Hôpital Henri Mondor,
51 avenue du Maréchal Lattre de Tassigny,
94010 Créteil, France
Tel: +33 1 49 81 27 32
Fax: +33 1 49 81 27 33
e-mail: [email protected]
Search for more papers by this authorAna Ponciano
Department of Pathology, Hospital General San Juan de Dios, Guatemala City, Guatemala
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorAnne de Muret
Service d'Anatomie et Cytologie Pathologiques, Hôpital Trousseau, CHRU de Tours, 37004 Tours Cedex 9, France
Search for more papers by this authorLaurent Machet
Service de Dermatologie, Hôpital Trousseau, CHRU de Tours, 37004 Tours Cedex 9, France
Search for more papers by this authorEmmanuel Gyan
Service d'Hématologie et Thérapie Cellulaire, Hôpital Bretonneau, 37000 Tours, France
Search for more papers by this authorChristophe Monegier du Sorbier
Centre de Pathologie Origet, 3 boulevard Alfred Nobel, 37540 Sant-Cyr-sur-Loire, France
Search for more papers by this authorValérie Molinier-Frenkel
AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Service d'Immunologie Biologique, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorPhilippe Gaulard
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Search for more papers by this authorCorresponding Author
Nicolas Ortonne
AP-HP, Groupe hospitalier Henri Mondor, Department of Pathology, Université Paris Est Créteil, Faculté de Médecine UMR-S955, and Inserm Unité 955, 94010 Créteil, France
Nicolas Ortonne
Department of Pathology,
Hôpital Henri Mondor,
51 avenue du Maréchal Lattre de Tassigny,
94010 Créteil, France
Tel: +33 1 49 81 27 32
Fax: +33 1 49 81 27 33
e-mail: [email protected]
Search for more papers by this authorAbstract
Angioimmunoblastic T-cell lymphoma (AITL) is frequently associated with skin lesions, but epidermotropic cutaneous involvement has never been described. A 37-year-old man presented with erythematous and pruriginous plaques, clinically suggestive of mycosis fungoides, distributed all over the body, 3 weeks after the last line of a polychemotherapy, given for an AITL diagnosed 1 year earlier on a lymph node biopsy. Skin biopsy showed an epidermotropic CD4+ T-cell lymphoma, so that a diagnosis of mycosis fungoides was first proposed. Further investigations showed that atypical lymphocytes strongly expressed CD10 and markers of follicular helper T cells (TFH) including PD1, BCL-6 and CXCL13. The diagnosis of an unusual epidermotropic cutaneous localization of the AITL was finally made, supported by the presence of the same T-cell clone in the initial lymph node biopsy and the skin. We therefore recommend performing markers of TFH cells in patients with unusual epidermotropic cutaneous T-cell lymphomas, particularly if they have any clinical features suggestive of AITL.
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