Original Article

A hyperactive postprandial response in the neorectum − the clue to low anterior resection syndrome after total mesorectal excision surgery?

Corresponding Author

K. J. Emmertsen

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

Correspondence to: Katrine J. Emmertsen, Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Tage-Hansens Gade 2, DK-8000 Aarhus C, Denmark.

E-mail: [email protected]

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S. Bregendahl,

S. Bregendahl

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

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J. Fassov,

J. Fassov

Neurogastroenterology Unit, Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark

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K. Krogh,

K. Krogh

Neurogastroenterology Unit, Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark

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S. Laurberg,

S. Laurberg

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

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K. J. Emmertsen,

Corresponding Author

K. J. Emmertsen

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

Correspondence to: Katrine J. Emmertsen, Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Tage-Hansens Gade 2, DK-8000 Aarhus C, Denmark.

E-mail: [email protected]

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S. Bregendahl,

S. Bregendahl

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

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J. Fassov,

J. Fassov

Neurogastroenterology Unit, Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark

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K. Krogh,

K. Krogh

Neurogastroenterology Unit, Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark

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S. Laurberg,

S. Laurberg

Surgical Research Unit, Colorectal Surgical Department, Aarhus University Hospital, Aarhus, Denmark

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First published: 19 July 2013

https://doi.org/10.1111/codi.12360

Citations: 53

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Abstract

Aim

To investigate neorectal properties regarding biomechanical, sensory and postprandial response in patients after total mesorectal excision without neoadjuvant radiotherapy in groups of no low anterior resection syndrome (LARS) patients and major LARS patients.

Method

Patients without LARS (n = 9) and patients with major LARS (n = 23) were investigated by multimodal rectal stimulation and standard anorectal physiological tests, and results were compared.

Results

Patients with major LARS had an increased postprandial response with a significant increase in pressure in the neorectum after a meal compared with patients without LARS (P = 0.017). No biomechanical differences could be detected.

Conclusion

Low anterior resection syndrome seems to be caused by physiological changes due to neural damage more than structural changes in the ano-neorectum.

References

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Citing Literature

Volume15, Issue10

October 2013

Pages e599-e606

A hyperactive postprandial response in the neorectum − the clue to low anterior resection syndrome after total mesorectal excision surgery?

Abstract

Aim

Method

Results

Conclusion

References

Citing Literature

References

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A hyperactive postprandial response in the neorectum − the clue to low anterior resection syndrome after total mesorectal excision surgery?

Abstract

Aim

Method

Results

Conclusion

References

Citing Literature

References

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