EAO Consensus Report
Complex systematic review - Perioperative antibiotics in conjunction with dental implant placement
Bodil Lund,
Margareta Hultin,
Sofia Tranæus,
Aron Naimi-Akbar,
Björn Klinge,
Corresponding Author
Bodil Lund
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden
Corresponding author:
Bodil Lund, DDS
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, S-141 86 Stockholm, Sweden
Tel.: +46858583950
Fax: +46858583522
e-mail: [email protected]
Search for more papers by this authorMargareta Hultin
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Search for more papers by this authorSofia Tranæus
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Swedish Council on Health Technology Assessment, Stockholm, Sweden
Department of Periodontology, Faculty of Odontology, Malmo University, Malmo, Sweden
Search for more papers by this authorAron Naimi-Akbar
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden
Search for more papers by this authorBjörn Klinge
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Periodontology, Faculty of Odontology, Malmo University, Malmo, Sweden
Search for more papers by this authorBodil Lund,
Margareta Hultin,
Sofia Tranæus,
Aron Naimi-Akbar,
Björn Klinge,
Corresponding Author
Bodil Lund
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden
Corresponding author:
Bodil Lund, DDS
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, S-141 86 Stockholm, Sweden
Tel.: +46858583950
Fax: +46858583522
e-mail: [email protected]
Search for more papers by this authorMargareta Hultin
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Search for more papers by this authorSofia Tranæus
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Swedish Council on Health Technology Assessment, Stockholm, Sweden
Department of Periodontology, Faculty of Odontology, Malmo University, Malmo, Sweden
Search for more papers by this authorAron Naimi-Akbar
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Huddinge, Sweden
Search for more papers by this authorBjörn Klinge
Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden
Department of Periodontology, Faculty of Odontology, Malmo University, Malmo, Sweden
Search for more papers by this authorAbstract
Objectives
The aim of this study was to revisit the available scientific literature regarding perioperative antibiotics in conjunction with implant placement by combining the recommended methods for systematic reviews and complex systematic reviews.
Material and methods
A search of Medline (OVID), The Cochrane Library (Wiley), EMBASE, PubMed and Health technology assessment (HTA) organizations was performed, in addition to a complementary hand-search. Selected systematic reviews and primary studies were assessed using GRADE and AMSTAR, respectively. A meta-analysis was performed.
Results
The literature search identified 846 papers of which 10 primary studies and seven systematic reviews were included. Quality assessment of the systematic reviews revealed two studies of moderate risk of bias and five with high risk of bias. The two systematic reviews of moderate risk of bias stated divergent numbers needed to treat (NNT) to prevent one patient from implant failure. Four of the primary studies comparing antibiotic prophylaxis with placebo were estimated to be of low, or moderate, risk of bias and subjected to meta-analysis. The NNT was 50 (pooled RR 0.39, 95% CI 0.18, 0.84; P = 0.02). None of these four studies individually show a statistical significant benefit of antibiotic prophylaxis. Furthermore, narrative analysis of the studies eligible for meta-analysis reveals clinical heterogeneity regarding intervention and smoking.
Conclusion
Antibiotic prophylaxis in conjunction with implant placement reduced the risk for implant loss by 2%. However, the sub-analysis of the primary studies suggests that there is no benefit of antibiotic prophylaxis in uncomplicated implant surgery in healthy patient.
References
- Abu-Ta'a, M., Quirynen, M., Teughels, W. & Van Steenberghe, D. (2008) Asepsis during periodontal surgery involving oral implants and the usefulness of peri-operative antibiotics: a prospective, randomized, controlled clinical trial. Journal of Clinical Periodontology 35: 58–63.
- Adell, R., Lekholm, U., Rockler, B. & Brånemark, P.I. (1981) A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. International Journal of Oral Surgery 10: 387–416.
- Ahmad, N. (2012) Effects of antibiotics on dental implants: a review. Journal of Clinical Medicine Research 4: 1–6.
- Albrektsson, T., Dahl, E., Enbom, M., Engevall, S., Engquist, B., Eriksson, A.R., Feldmann, G., Freiberg, N., Glantz, P.O., Kjelmann, O., Kristersson, L., Kvint, S., Köndell, P.-Å., Palmquist, J., Werndahl, L. & Åstrand, P. (1988) Osseointegrated oral implants. A Swedish multicenter study of 8139 consecutively inserted Nobelpharma implants. Journal of Periodontology 59: 287–296.
- Aldrin, M., Raastad, R., Tvete, I.F., Berild, D., Frigessi, A., Leegaard, T., Monnet, D.L., Walberg, M. & Müller, F. (2013) Antibiotic resistance in hospitals: a ward-specific random effect model in low antibiotic consumption environments. Statistics in Medicine 32: 1407–1418.
- Andersen, B.R., Kallehave, F.L. & Andersen, H.K. (2005) Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database of Systematic Reviews 2005: CD001439.
- Anitua, E., Aguirre, J.J., Gorosabel, A., Barrio, P., Errazquin, J.M., Román, P., Pla, R., Carrete, J., de Petro, J. & Orive, G. (2009) A multicentre placebo-controlled randomised clinical trial of antibiotic prophylaxis for placement of single dental implants. European Journal of Oral Implantology 2: 283–292.
- Astrand, P., Ahlqvist, J., Gunne, J. & Nilson, H. (2008) Implant treatment of patients with edentulous jaws: a 20-year follow-up. Clinical Implant Dentistry and Related Research 10: 207–217.
- Ata-Ali, J.A.A., Ata-Ali, F. & Ata-Ali, F. (2014) Do antibiotics decrease implant failure and postoperative infections? A systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery 43: 68–74.
- Atkins, D., Best, D., Briss, P.A., Eccles, M., Falck-Ytter, Y., Flottorp, S., Guyatt, G.H., Harbour, R.T., Haugh, M.C., Henry, D., Hill, S., Jaeschke, R., Leng, G., Liberati, A., Magrini, N., Mason, J., Middleton, P., Mrukowicz, J., O'Connell, D., Oxman, A.D., Phillips, B., Schünemann, H.J., Edejer, T., Varonen, H., Vist, G.E., Williams, J.W., Jr & Zaza, S.; GRADE Working Group (2004) Grading quality of evidence and strength of recommendations. British Medical Journal 328: 1490.
- Bell, C.M., Urbach, D.R., Ray, J.G., Bayoumi, A., Rosen, A.B., Greenberg, D. & Neumann, P.J. (2006) Bias in published cost effectiveness studies: systematic review. British Medical Journal 332: 699–703.
- Binahmed, A.S., Stoykewych, A., & Peterson, L. (2005) Single preoperative dose versus long-term prophylactic antibiotic regimens in dental implant surgery. The International Journal of Oral & Maxillofacial Implants 20: 115–117.
- Booth, A., Clarke, M., Ghersi, D., Hoher, D., Petticrew, M. & Stewart, L. (2011) An international registry of systematic-review protocols. The Lancet 377: 108–109.
- Bowen Antolin, A.P., Pascua Garcia, M.T. & Nasimi, A. (2007) Infections in implantology: from prophylaxis to treatment. Medicina Oral, Patología Oral y Cirugía Bucal 12: E323–E330.
- Brand, B., Johnson, J.T., Myers, E.N., Thearle, P.D. & Sigler, B.A. (1982) Prophylactic perioperative antibiotics in contaminated head and neck surgery. Otolaryngology – Head and Neck Surgery 90: 315–318.
- Bronzwaer, S.L., Cars, O., Buchholz, U., Mölstad, S., Goettsch, W., Veldhuijzen, I.K., Kool, J.L., Sprenger, M.J. & Degener, J.E.; European Antimicrobial Resistance Surveillance System (2002) A European study on the relationship between antimicrobial use and antimicrobial resistance. Emerging Infectious Diseases 8: 278–282.
- Caiazzo, A., Casavecchia, P., Barone, A. & Brugnami, F. (2011) A pilot study to determine the effectiveness of different amoxicillin regimens in implant surgery. The Journal of Oral Implantology 37: 691–696.
- Carroll, W.R., Rosenstiel, D., Fix, J.R., de la Torre, J., Solomon, J.S., Brodish, B., Rosenthal, E.L., Heinz, T., Niwas, S. & Peters, G.E. (2003) Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of head and neck. Archives of Otolaryngology – Head and Neck Surgery 129: 771–774.
- Chardin, H., Yasukawa, K., Nouacer, N., Plainvert, C., Aucouturier, P., Ergani, A., Descroix, V., Toledo-Arenas, R., Azerad, J. & Bouvet, A. (2009) Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure. Journal of Medical Microbiology 58: 1092–1097.
- Chrcanovic, B., Albrektsson, T. & Wennerberg, A. (2014) Prophylactic antibiotic regimen and dental implant failure: a meta-analysis. Journal of Oral Rehabilitation 41: 941–956.
- Coulthard, P.E., Esposito, M., Slater, M., Worthington, H.V. & Kay, E.J. (2003) Prevention. Part 5: Preventive strategies for patients requiring osseointegrated oral implant treatment. British Dental Journal 195: 187–194.
- Davies, S.C., Fowler, T., Watson, J., Livermore, D.M. & Walker, D. (2013) Annual report of the Chief Medical Officer: infection and the rise of antimicrobial resistance. Lancet 381: 1606–1609.
- Deeks, J.J., Higgins, J.P.T. & Altman, D.G. (2011) Chapter 9: Analysing data and undertaking meta-analyses. In: J.P. Higgins & S. Green, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (update March 2011). The Cochrane Collaboration, 2011. Assessed on 1/3/2015 at www.cochrane-handbook.org.
- Dent, C., Olson, J.W., Farish, S.E., Bellome, J., Casino, A.J., Morris, H.F. & Ochi, S. (1997) The influence of preoperative antibiotics on success of endosseous implants up to and including stage II surgery: a study of 2,641 implants. Journal of Oral and Maxillofacial Surgery 55: s19–s24.
- Doem, C.D. & Burnham, C.A. (2010) It's not easy being green: the viridans group streptococci, with a focus on pediatric clinical manifestations. Journal of Clinical Microbiology 48: 3829–3835.
- Dowson, C.G., Hutchison, A., Woodford, N., Johnson, A.P., George, R.C. & Spratt, B.G. (1990) Penicillin-resistant viridans streptococci have obtained altered penicillin-bindning protein genes from penicillin-resistant strains of Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America 87: 5858–5862.
- Dundar, Y., Dodd, S., Dickson, R., Walley, T., Haycox, A. & Williamson, P.R. (2006) Comparison of conference abstracts and presentations with full-text articles in the health technology assessments of rapidly evolving technologies. Health Technology Assessment 10: 1–145.
10.3310/hta10050 Google Scholar
- Ekelund, J.A., Lindquist, L.W., Carlsson, G.E. & Jemt, T. (2003) Implant treatment in the edentulous mandible: a prospective study on Branemark system implants over more than 20 years. International Journal of Prosthodontics 16: 602–608.
- El-Kholey, K.E. (2014) Efficacy of two antibiotic regimens in the reduction of early dental implant failure: a pilot study. International Journal of Oral and Maxillofacial Surgery 43: 487–490.
- Esposito, M., Cannizzaro, G., Bozzoli, P., Checchi, L., Ferri, V., Landriani, S., Leone, M., Todisco, M., Torchio, C., Testori, T., Galli, F. & Felice, P. (2010a) Effectiveness of prophylactic antibiotics at placement of dental implants: a pragmatic multicentre placebo-controlled randomised clinical trial. European Journal of Oral Implantology 3: 135–143.
- Esposito, M., Cannizzaro, G., Bozzoli, P., Consolo, U., Felice, P., Ferri, V., Landriani, S., Leone, M., Magliano, A., Pellitteri, G., Todisco, M. & Torchio, C. (2008a) Efficacy of prophylactic antibiotics for dental implants: a multicentre placebo-controlled randomised clinical trial. European Journal of Oral Implantology 1: 23–31.
- Esposito, M., Grusovin, M.G., Coulthard, P., Oliver, R. & Worthington, H. (2008b) The efficacy of antibiotic prophylaxis at placement of dental implants: a Cochrane systematic review of randomised controlled clinical trials. European Journal of Oral Implantology 1: 95–103.
- Esposito, M., Grusovin, M.G., Talati, M., Coulthard, P., Oliver, R. & Worthington, H.V. (2008c) Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications. Cochrane Database Systematic Reviews 2008: CD004152.
- Esposito, M., Hirsch, J.M., Lekholm, U. & Thomsen, P. (1998) Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. European Journal of Oral Sciences 106: 721–764.
- Esposito, M., Grusovin, M.G., Loli, V., Coulthard, P. & Worthington, H. (2010b) Does antibiotic prophylaxis at implant placement decrease early implant failures? A Cochrane systematic review. European Journal of Oral Implantology 3: 101–110.
- Esposito, M., Oliver, R., Thomsen, P. & Worthington, H. (2003) Antibiotics to prevent complications following dental implant treatment. Cochrane Database of Systematic Reviews, 2003: CD004152.
- Esposito, M. & Worthington, H. (2013) Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications. The Cochrane Database of Systematic Reviews 2013: CD004152.
- Esposito, M., Worthington, H.W., Loli, V., Coulthard, P. & Grusovin, M.G. (2010c) Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications. Cochrane Database of Systematic Reviews, 2010: CD004152.
- Foucault, C. & Brouqui, P. (2007) How to fight antimicrobial resistance. FEMS Immunology and Medical Microbiology 49: 173–183.
- Garg, A.R. (1992) Pharmacological agents used in implant dentistry. Parts II and III. Implant Society 3: 1, 5–8, 16.
- Garg, L.C. (2001) Preventing and treating infections related to dental implant placement. Interview. Dental Implantology Update 12: 73–77.
- Garg, A.K. (2004) Complications associated with implant surgical procedures part 1: prevention. Dental Implantology Update 15: 25–32.
- Givens, E., Bencharit, S., Byrd, W., Hosseini, B., Phillips, C. & Tyndall, D. (2013) Immediate placement and provisionalization of implants into sites with periradicular infection with or without antibiotics: an exploratory study. Journal of Oral Implantology doi: 10.1563/AAID-JOI-D-13-00002. [Epub ahead of print].
- Greenstein, G., Cavallaro, J., Romanos, G. & Tarnow, D. (2008) Clinical recommendations for avoiding and managing surgical complications associated with implant dentistry: a review. Journal of Periodontology 79: 1317–1329.
- Guyatt, G., Oxman, A.D., Akl, E.A., Kunz, R., Vist, G., Brozek, J., Norris, S., Falck-Ytter, Y., Glasziou, P., DeBeer, H., Jaeschke, R., Rind, D., Meerpohl, J., Dahm, P. & Schünemann, H.J. (2011) GRADE guidelines 1. Introduction – GRADE evidence profiles and summary of finding tables. Journal of Clinical Epidemiology 64: 383–394.
- Guyatt, G., Oxman, A., Vist, G., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P. & Schüneman, H. (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. British Medical Journal 336: 924–926.
- Gynther, G.W., Köndell, P.Å., Moberg, L.E. & Heimdahl, A. (1998) Dental implant installation without antibiotic prophylaxis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 85: 509–511.
- Heitz-Mayfield, L.J., Needleman, I., Salvi, G.E. & Pjetursson, B.E. (2014) Consensus statements and clinical recommendations for prevention and management of biologic and technical implant complications. International Journal of Oral & Maxillofacial Implants 29(Suppl.): 346–350.
- Higgins, J.P. & Thompson, S.G. (2002) Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 21: 1539–1558.
- Hopkins, L. & Smaill, F. (2012) Antibiotic prophylaxis regimens and drugs for caesarean section. Cochrane Database of Systematic Reviews 2012: CD001136.
- Hosseini, B.B., Preisser, J.S., Khan, A., Duggan, D. & Bencharit, S. (2014) Effects of antibiotics on bone and soft tissue healing following immediate single-tooth implant placement into sites with apical pathology. Journal of Oral Implantology doi: 10.1563/aaid-joi-D-14-00075. [Epub ahead of print].
- Hughes, V.M. & Datta, N. (1983) Conjugative plasmids in bacteria of the ‘pre-antibiotic’ era. Nature 302: 725–726.
- Jemt, T. & Johansson, J. (2006) Implant treatment in the edentulous maxillae: a 15-year follow-up study on 76 consecutive patients provided with fixed prostheses. Clinical Implant Dentistry and Related Research 8: 61–69.
- Jernberg, C., Löfmark, S., Edlund, C. & Jansson, J.K. (2010) Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology 156: 3216–3223.
- Johnson, J.T., Yu, V.L., Myers, E.N., Muder, R.R., Thearle, P.B. & Diven, W.F. (1984) Efficacy of two-third generation cephalosporins in prophylaxis for head and neck surgery. Archives of Otolaryngology 110: 224–227.
- Jönsson, M. & Swedberg, G. (2006) Macrolide resistance can be transferred by conjugation from viridans streptococci to Streptococcus pyogenes. International Journal of Antimicrobial Agents 28: 101–103.
- Jörgensen, A.W., Maric, K.L., Tendal, B., Faurschou, A. & Götzsche, P.C. (2008) Industry-supported meta-analysis compared with meta-analysis with non-profit or no support: differences in methodological quality and conclusion. BMC Medical Research Methodology 8: 60.
- Kang, S.H., Yoo, J.H. & Yi, C.K. (2009) The efficacy of postoperative prophylactic antibiotics in orthognatic surgery: a prospective study in Le Fort I osteotomy and bilateral intraoral vertical ramus osteotomy. Yonsei Medical Journal 50: 55–59.
- Karaky, A., Sawair, F.A., Al-Karadsheh, O.A., Eimar, H.A., Algarugly, S.A. & Baqain, Z.H. (2011) Antibiotic prophylaxis and early dental implant failure: a quasi-random controlled clinical trial. European Journal of Oral Implantology 4: 31–38.
- Khalil, D., Hultin, M., Andersson Fred, L., Parkbring Olsson, N. & Lund, B. (2014) Antibiotic prescription patterns among Swedish dentists working with dental implants surgery. Adherence to recommendations. Clinical Oral Implants Research doi: 10.1111/clr.12402. [Epub ahead of print].
- Kim, D.M., Badovinac, R.L., Lorenz, R.L., Fiorellini, J.P. & Weber, H.P. (2008) A 10-year prospective clinical and radiographic study of one-stage dental implants. Clinical Oral Implants Research 19: 254–258.
- Laskin, D.M., Dent, C.D., Morris, H.F., Ochi, S. & Olson, J.W. (2000) The influence of preoperative antibiotics on success of endosseous implants at 36 months. Annals of Periodontology/the American Academy of Periodontology 5: 166–174.
- Lawler, B.S., Sambrook, P.J. & Goss, A.N. (2005) Antibiotic prophylaxis for dentoalveolar surgery: is it indicated? Australian Dental Journal 50: s54–s59.
- Lefebvre, C., Manheimer, E. & Glanville, J. (2011) Chapter 6.1.1.2: Minimizing bias. In: J.P.T. Higgins & S. Green, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. http://www.cochranehandbook.org/.
- Lekholm, U., Grondahl, K. & Jemt, T. (2006) Outcome of oral implant treatment in partially edentulous jaws followed 20 years in clinical function. Clinical Implant Dentistry and Related Research 8: 178–186.
- Lekholm, U., Gunne, J., Henry, P., Higuchi, K., Linden, U., Bergstrom, C. & Van Steenberghe, D. (1999) Survival of the Brånemark implant in partially edentulous jaws: a 10-year prospective multicenter study. International Journal of Oral & Maxillofacial Implants 14: 639–645.
- Lexchin, J., Bero, L.A., Djulbegovic, B. & Clark, O. (2003) Pharmaceutical industry sponsorship and research outcome and quality: systematic review. British Medical Journal 326: 1167–1170.
- Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gøtzsche, P.C., Ioannidis, J.P., Clarke, M., Devereaux, P.J., Kleijnen, J. & Moher, D. (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLos Medicine 6: e1000100.
- Liu, S.A., Tung, K.C., Shiao, J.Y. & Chiu, Y.T. (2008) Preliminary report of associated factors in wound infection after major head and neck neoplasm operations – does the duration of prophylactic antibiotic matter? Journal of Laryngology and Otology 122: 403–408.
- Livermore, D.M. (2005) Minimising antibiotic resistance. Lancet Infectious Diseases 5: 450–459.
- Moher, D., Liberati, A., Tetzlaff, J. & Altman, D.G.; for the PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLos Medicine 6: e1000151.
- Morris, H.F., Ochi, S., Plezia, R., Gilbert, H., Dent, C.D., Pikulski, J. & Lambert, P.M. (2004) AICRG, Part III: The influence of antibiotic use on the survival of a new implant design. The Journal of Oral Implantology 30: 144–151.
- Nolan, R., Kemmoona, M., Polyzois, I. & Claffey, N. (2014) The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial. Clinical Oral Implants Research 25: 252–259.
- Oomens, M.A., Verlinden, C.R., Goey, Y. & Forouzanfar, T. (2014) Prescribing antibiotic prophylaxis in orthognatic surgery: a systematic review. International Journal of Oral and Maxillofacial Surgery 43: 725–731.
- Pjetursson, B., Thoma, D., Jung, R., Zwahlen, M. & Zembic, A. (2012) A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years (Provisional abstract). Clinical Oral Implants Research 23: S22–S38.
- Pjetursson, B.E., Tan, K., Lang, N.P., Brägger, U., Egger, M. & Zwahlen, M. (2004) A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years. Clinical Oral Implants Research 15: 667–676.
- Pye, A.D., Lockhart, D.E., Dawson, M.P., Murray, C.A. & Smith, A.J. (2009) A review of dental implants and infection. Journal of Hospital Infection 72: 104–110.
- Righi, M., Manfredi, R., Farneti, G., Pasquini, E. & Cenacchi, V. (1996) Short-term versus long-term antimicrobial prophylaxis in oncologic head and neck surgery. Head and Neck 18: 399–404.
10.1002/(SICI)1097-0347(199609/10)18:5<399::AID-HED2>3.0.CO;2-0 CAS PubMed Web of Science® Google Scholar
- Rizzo, S.Z., Zampetti, P., Rodriguez, Y., Baena, R., Svanosio, D. & Lupi, S.M. (2010) Retrospective analysis of 521 endosseous implants placed under antibiotic prophylaxis and review of literature. Minerva Stomatologica 59: 75–88.
- Roos-Jansåker, A.M., Lindahl, C., Renvert, H. & Renvert, S. (2006b) Nine- to fourteen-year follow- up of implant treatment. Part II: presence of peri-implant lesions. Journal of Clinical Periodontology 33: 290–295.
- Roos-Jansåker, A.M., Lindahl, C., Renvert, H. & Renvert, S. (2006a) Nine- to fourteen-year follow-up of implant treatment. Part I. Implant loss and patient related factors. Journal of Clinical Periodontology 33: 283–289.
- Schulz, K.F., Altman, D.G. & Moher, D.; CONSORT Group. (2010) CONSORT 2010 Statement; updated guidelines for reporting parallel group randomised trials. BMC Medicine 8: 18.
- Schwartz, A.B. & Larson, E.L. (2007) Antibiotic prophylaxis and postoperative complications after tooth extraction and implant placement: a review of the literature. Journal of Dentistry 35: 881–888.
- Sennerby, L.R. & Roos, J. (1998) Surgical determinants of clinical success of osseointegrated oral implants: a review of the literature. The International Journal of Prosthodontics 11: 408–420.
- Sharaf, B.D. & Dodson, T.B. (2011) Does the Use of Prophylactic Antibiotics Decrease Implant Failure? Oral and Maxillofacial Surgery Clinics of North America 23: 547–550.
- Sharaf, B.J.-R., Jandali-Rifai, M., Susarla, S.M. & Dodson, T.B. (2011) Do perioperative antibiotics decrease implant failure? Journal of Oral and Maxillofacial Surgery 69: 2345–2350.
- Shea, B.J., Bouter, L.M., Peterson, J., Boers, M., Andersson, N., Ortiz, Z., Ramsay, T., Bai, A., Shukla, V.K. & Grimshaw, J.M. (2007a) External validation of a measurement tool to assess systematic reviews (AMSTAR). PLoS One 2: e1350.
- Shea, B.J., Grimshaw, J.M., Wells, G.A., Boers, M., Andersson, N., Hamel, C., Porter, A.C., Tugwell, P., Moher, D. & Bouter, L.M. (2007b) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Medical Research Methodology 7: 10.
- Shea, B.J., Hamel, C., Wells, G.A., Bouter, L.M., Kristjansson, E., Grimshaw, J., Henry, D.A. & Boers, M. (2009) AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. Journal of Clinical Epidemiology 62: 1013–1020.
- Song, F. & Glenny, A.M. (1998) Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomozed controlled trials. The British Journal of Surgery 85: 1232–1241.
- Straus, S. & Moher, D. (2009) Registering systematic reviews. Canadian Medical Association Journal 182: 13–14.
- Swedish Council on Health Technology Assessment. (2010) Antibiotic Prophylaxis for Surgical Procedures. In Swedish: Antibiotikaprofylax vid kirurgiska ingrepp. En systematisk litteraturöversikt. Stockholm: Statens beredning för medicinsk utvärdering (SBU); 2010. SBU-rapport nr 200. ISBN 978-91-85413-36-2.
- Tan, W.C., Ong, M., Han, J., Mattheos, N., Pjetursson, B.E., Tsai, A.Y., Sanz, I., Wong, M.C. & Lang, N.P. (2014) Antibiotic Study Group. Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy – a multicenter randomized controlled clinical trial. Clinical Oral Implants Research 25: 185–193.
- Tomson, G. & Vlad, I. (2014) The need to look at antibiotic resistance from a health system perspective. Upsala Journal of Medical Sciences 119: 117–124.
- Trieger, N. (1999) Antibiotics and anti-inflammatory agents in dental implantology. Implant Dentistry 8: 343–346.
- Van der Waaij, D. (1983) Colonization of the digestive tract by potentially pathogenic microorganisms: colonization controlling mechanisms and consequences for antibiotic treatment. Infection 11: S90–S92.
- Whitlock, E.P., Lin, J.S., Chou, R., Shekelle, P. & Robinson, K.A. (2008) Using existing systematic reviews in complex systematic reviews. Annals of Internal Medicine 148: 776–782.
- Zablotsky, M.H. (1993) Chemotherapeutics in implant dentistry. Implant Dentistry 2: 19–25.
