Clinical Implant Dentistry and Related Research

ORIGINAL ARTICLE

Clinical indices and local levels of inflammatory biomarkers in per-implant health of obese and nonobese individuals

Mohammed N. Alasqah MSc, DABP

Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia

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Nouf Al-Shibani MSD,PhD,

Nouf Al-Shibani MSD,PhD

Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia

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Khulud Abdulrahman Al-Aali CAGS, DScD,

Khulud Abdulrahman Al-Aali CAGS, DScD

Department of Prosthodontics, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

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Osama A. Qutub DScD,

Osama A. Qutub DScD

Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

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Tariq Abduljabbar DMSc,

Corresponding Author

Tariq Abduljabbar DMSc

[email protected]

orcid.org/0000-0001-7266-5886

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia

Correspondence

Tariq Abduljabbar, Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.

Email: [email protected]

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Zohaib Akram MDSc,

Zohaib Akram MDSc

orcid.org/0000-0001-9618-8818

Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan

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Mohammed N. Alasqah MSc, DABP,

Mohammed N. Alasqah MSc, DABP

Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia

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Nouf Al-Shibani MSD,PhD,

Nouf Al-Shibani MSD,PhD

Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia

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Khulud Abdulrahman Al-Aali CAGS, DScD,

Khulud Abdulrahman Al-Aali CAGS, DScD

Department of Prosthodontics, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

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Osama A. Qutub DScD,

Osama A. Qutub DScD

Oral and Maxillofacial Prosthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

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Tariq Abduljabbar DMSc,

Corresponding Author

Tariq Abduljabbar DMSc

[email protected]

orcid.org/0000-0001-7266-5886

Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia

Correspondence

Tariq Abduljabbar, Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.

Email: [email protected]

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Zohaib Akram MDSc,

Zohaib Akram MDSc

orcid.org/0000-0001-9618-8818

Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan

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First published: 13 December 2018

https://doi.org/10.1111/cid.12700

Citations: 15

Funding information Deanship of Scientific Research, King Saud University, Grant/Award Number: RG-1438-075

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Abstract

Background

Obesity seem to regulate peri-implant health. It is proposed that peri-implant crevicular fluid (PICF) levels of interleukin (IL)-1β and IL-6 are higher in obese as compared to nonobese individuals.

Objective

The purpose of the present clinico-laboratory study is to estimate and compare the clinical and radiographic indices and PICF levels of IL-1β and IL-6 among obese and nonobese patients.

Materials and Methods

Fifty patients were divided into two groups (25 obese with ≥27.5 kg/m² and 25 nonobese with <27.5 kg/m² individuals). Clinical indices for both periodontal and peri-implant evaluating plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), and crestal bone loss (CBL) were recorded around teeth and implants. PICF was collected and assessed for the levels of IL-1β and IL-6 using enzyme-linked immunosorbent assay.

Results

A significant difference was observed in PI and BOP around natural teeth and implants in obese patients, respectively (P < .05). CBL was found to be significantly higher among obese as compared to nonobese patients (P = .022). Peri-implant and periodontal PD was higher in obese as compared to nonobese but did not reach statistical significance. Levels of IL-1β and IL-6 were statistically significantly higher among obese patients as compared to nonobese (P = .001). Pearson correlation analysis showed IL-1β was positively correlated with CBL (P = .0079), whereas IL-6 showed positive correlation with both BOP (P = .0019) and CBL (P = .015) among obese patients.

Conclusions

Clinical peri-implant parameters were worse and proinflammatory biomarkers were significantly higher in obese patients compared with nonobese subjects. The findings of the present study suggests that increased proinflammatory biomarkers in PICF of obese patients may modulate peri-implant inflammation around dental implants.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interests.

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Citing Literature

Volume21, Issue1

February 2019

Pages 80-84

Clinical indices and local levels of inflammatory biomarkers in per-implant health of obese and nonobese individuals

Abstract

Background

Objective

Materials and Methods

Results

Conclusions

CONFLICT OF INTEREST

REFERENCES

Citing Literature

References

Information

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