In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1
Corresponding Author
Kostas Bougas DDS
PhD student
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Reprint requests: Mr. Kostas Bougas, Department of Prosthodontics, Faculty of Odontology, Malmö University, 20506 Malmö, Sweden; e-mail: [email protected]Search for more papers by this authorRyo Jimbo DDS, PhD
associate professor
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorStefan Vandeweghe DDS, PhD
senior researcher
Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium
Search for more papers by this authorNick Tovar PhD
adjunct professor
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorMarta Baldassarri PhD
researcher
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorAli Alenezi DDS
MSc student
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorMalvin Janal PhD
senior scientist
Department of Epidemiology and Health Promotion, New York University, New York, USA
Search for more papers by this authorPaulo G. Coelho DDS, PhD
assistant professor
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorAnn Wennerberg DDS, PhD
professor and head
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorCorresponding Author
Kostas Bougas DDS
PhD student
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Reprint requests: Mr. Kostas Bougas, Department of Prosthodontics, Faculty of Odontology, Malmö University, 20506 Malmö, Sweden; e-mail: [email protected]Search for more papers by this authorRyo Jimbo DDS, PhD
associate professor
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorStefan Vandeweghe DDS, PhD
senior researcher
Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium
Search for more papers by this authorNick Tovar PhD
adjunct professor
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorMarta Baldassarri PhD
researcher
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorAli Alenezi DDS
MSc student
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorMalvin Janal PhD
senior scientist
Department of Epidemiology and Health Promotion, New York University, New York, USA
Search for more papers by this authorPaulo G. Coelho DDS, PhD
assistant professor
Department of Biomaterials and Biomimetics, New York University, New York, USA
Search for more papers by this authorAnn Wennerberg DDS, PhD
professor and head
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Search for more papers by this authorAbstract
Purpose
The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo.
Materials and Methods
Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1.
Results
After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone.
Conclusions
Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
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