ORIGINAL ARTICLE

Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

Corresponding Author

M. Elisabeth Heal DO, MSCR

[email protected]

orcid.org/0000-0001-5057-1141

Children's Hospital of Philadelphia, Department of Pediatrics, Division of Cardiology, Philadelphia, PA 19104, USA

Correspondence Elisabeth Heal, 3401 Civic Center Blvd, Philadelphia PA 19104. Email: [email protected]Search for more papers by this author

Lanier B. Jackson MD, MSCR,

Lanier B. Jackson MD, MSCR

Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425

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Andrew M. Atz MD,

Andrew M. Atz MD

Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425

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Ryan J. Butts MD,

Ryan J. Butts MD

Department of Pediatrics, Division of Cardiology, University of Texas Southwestern, Dallas, TX 75235

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M. Elisabeth Heal DO, MSCR,

Corresponding Author

M. Elisabeth Heal DO, MSCR

[email protected]

orcid.org/0000-0001-5057-1141

Children's Hospital of Philadelphia, Department of Pediatrics, Division of Cardiology, Philadelphia, PA 19104, USA

Correspondence Elisabeth Heal, 3401 Civic Center Blvd, Philadelphia PA 19104. Email: [email protected]Search for more papers by this author

Lanier B. Jackson MD, MSCR,

Lanier B. Jackson MD, MSCR

Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425

Search for more papers by this author

Andrew M. Atz MD,

Andrew M. Atz MD

Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425

Search for more papers by this author

Ryan J. Butts MD,

Ryan J. Butts MD

Department of Pediatrics, Division of Cardiology, University of Texas Southwestern, Dallas, TX 75235

Search for more papers by this author

First published: 15 June 2017

https://doi.org/10.1111/chd.12451

Citations: 13

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Abstract

Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration −4.9 ± 3.8 v. nonfenestration −3 ± 3.5; P < .001). Physiological dead space at peak exercise was higher in fenestrated v. nonfenestrated (25.2 ± 16.1 v. 21.4 ± 15.2; P = .03). There was a weak association between fenestration patency and maximal work and heart rate. Fenestration patency was also weakly correlated with oxygen pulse, work and VE/VCO2 at AT. The effect of persistent fenestration on CPET measurements was minimal in this study, likely due to the cross-sectional design.

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Volume12, Issue4

July/August 2017

Pages 399-402

Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

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Effects of persistent Fontan fenestration patency on cardiopulmonary exercise testing variables

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