ORIGINAL ARTICLE

Resting Energy Expenditure at 3 Months of Age Following Neonatal Surgery for Congenital Heart Disease

Corresponding Author

Sharon Y. Irving RN, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

Division of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Corresponding Author: Sharon Y Irving, PhD, RN, University of Pennsylvania School of Nursing, Claire M. Fagan Hall, 418 Curie Boulevard, Rm. 427, Philadelphia, PA 19104, USA. Tel: 215-746-2741; Fax: 215-746-3374; E-mail: [email protected]Search for more papers by this author

Barbara Medoff-Cooper RN, PhD,

Barbara Medoff-Cooper RN, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

The Cardiac Center, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

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Nicole O. Stouffer MS,

Nicole O. Stouffer MS

Stouffer and Associates Medical Research Support, Mount Laurel, NJ, USA

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Joan I. Schall PhD,

Joan I. Schall PhD

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

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Chitra Ravishankar MD,

Chitra Ravishankar MD

The Cardiac Center, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Department of Pediatrics, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

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Charlene W. Compher RD, PhD,

Charlene W. Compher RD, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

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Bradley S. Marino MD,

Bradley S. Marino MD

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

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Virginia A. Stallings MD,

Virginia A. Stallings MD

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

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Sharon Y. Irving RN, PhD,

Corresponding Author

Sharon Y. Irving RN, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

Division of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Barbara Medoff-Cooper RN, PhD,

Barbara Medoff-Cooper RN, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

The Cardiac Center, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Search for more papers by this author

Nicole O. Stouffer MS,

Nicole O. Stouffer MS

Stouffer and Associates Medical Research Support, Mount Laurel, NJ, USA

Search for more papers by this author

Joan I. Schall PhD,

Joan I. Schall PhD

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Search for more papers by this author

Chitra Ravishankar MD,

Chitra Ravishankar MD

The Cardiac Center, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

Department of Pediatrics, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

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Charlene W. Compher RD, PhD,

Charlene W. Compher RD, PhD

School of Nursing, University of Pennsylvania, Philadelphia, Pa, USA

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Bradley S. Marino MD,

Bradley S. Marino MD

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

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Virginia A. Stallings MD,

Virginia A. Stallings MD

Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa, USA

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pa, USA

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First published: 30 January 2013

https://doi.org/10.1111/chd.12035

Citations: 28

Funding: NIH/NINR R01 NR002093; MO1-RR00240; UL1-RR-024134. This project was supported by the National Institutes of Health, National Institute of Nursing Research, and the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.

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Abstract

Objective

Infants with Congenital Heart Disease (CHD) often exhibit growth failure. This can affect anthropometric and neurodevelopmental outcomes well into childhood. To determine the resting energy expenditure (REE), body composition, and growth in infants with CHD at 3 months of age, with the secondary aim to identify predictors of REE as compared with healthy infants.

Design and Methods.

This descriptive study is a subanalysis of a prospective study investigating predictors of growth in postoperative infants with CHD compared with healthy infants. Growth measurements, REE, and body composition were obtained in all infants. Analysis included chi-square for association between categorical variables, t-tests, ANOVA and ANCOVA. Outcome measures included the REE as determined by indirect calorimetry, anthropometric z-scores and body composition at 3 months of age.

Setting.

Participants were recruited from the Cardiac Intensive Care Unit of a large, urban, pediatric cardiac center and pediatric primary care practices.

Results.

The analysis included 93 infants, 44 (47%) with CHD. Of the infants with CHD, 39% had single ventricle (SV) physiology. There was no difference in REE related to cardiac physiology between infants with CHD and healthy infants or between infants with SV and biventricular (BV) physiology. Anthropometric z-scores for weight (−1.1 ± 1.1, P < 0.001), length (−0.7 ± 1.1, P < 0.05), and head circumference (−0.6 ± 1.2, P < 0.001) were lower in infants with CHD at 3 months of age. The percentage of body fat (%FAT) in postoperative infants with SV (24% ± 6, P = 0.02) and BV (23% ± 5, P < 0.001) physiology were lower than in healthy infants (27% ± 5), with no difference in REE.

Conclusion.

At 3 months of age, there was no difference in REE between postsurgical infants with CHD and healthy infants. Infants with CHD had lower growth z-scores and %FAT. These data demonstrate decreased %FAT contributed to growth failure in the infants with CHD.

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Volume8, Issue4

July/August 2013

Pages 343-351

Resting Energy Expenditure at 3 Months of Age Following Neonatal Surgery for Congenital Heart Disease

Abstract

Objective

Design and Methods.

Setting.

Results.

Conclusion.

References

Citing Literature

References

Information

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Resting Energy Expenditure at 3 Months of Age Following Neonatal Surgery for Congenital Heart Disease

Abstract

Objective

Design and Methods.

Setting.

Results.

Conclusion.

References

Citing Literature

References

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