LETTER TO THE EDITOR
‘Pseudothrombocytopenia’ a contradictory term in patients with normal platelet counts?
Peter Schuff-Werner,
Corresponding Author
Peter Schuff-Werner
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Rostock (UMR), Rostock, Germany
Medical Laboratory Osnabrück, Georgsmarienhütte, Germany
Correspondence
Peter Schuff-Werner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Rostock (UMR), Schillingallee 35, D-18057 Rostock, Germany.
Email: [email protected]
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Peter Schuff-Werner,
Corresponding Author
Peter Schuff-Werner
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Rostock (UMR), Rostock, Germany
Medical Laboratory Osnabrück, Georgsmarienhütte, Germany
Correspondence
Peter Schuff-Werner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Rostock (UMR), Schillingallee 35, D-18057 Rostock, Germany.
Email: [email protected]
Search for more papers by this author
First published: 26 January 2025
No abstract is available for this article.
REFERENCES
- 1Casonato A, Bertomoro A, Pontara E, Dannhauser D, Lazzaro AR, Girolami A. EDTA dependent pseudothrombocytopenia caused by antibodies against the cytoadhesive receptor of platelet gpIIB-IIIA. J Clin Pathol. 1994; 47(7): 625–630.
- 2Ghali C, Scavone M, Clerici B, Bossi E, Fioretti A, Pisetta C, et al. Time-dependent in vitro variations of platelet count in samples from subjects with EDTA-induced pseudothrombocytopenia: a comparative analysis across different anticoagulants. Br J Haematol. 2024; 204(5): 2125–2128.
- 3Schuff-Werner P, Steiner M, Fenger S, Gross H-J, Bierlich A, Dreissiger K, et al. Effective estimation of correct platelet counts in pseudothrombocytopenia using an alternative anticoagulant based on magnesium salt. Br J Haematol. 2013; 162(5): 684–692.
- 4Scavone M, Bossi E, Podda GM, Cattaneo M. MgSO4 anticoagulant prevents pseudothrombocytopenia by preserving the integrity of the platelet GPIIb-IIIa complex. Br J Haematol. 2021; 192(6): e144–e148.
- 5Schuff-Werner P, Mansour J, Gropp A, Pseudo-thrombocytopenia (PTCP). A challenge in the daily laboratory routine? J Lab Med. 2020; 44(5): 295–304.
- 6Mansour J, Mannuß S, Gropp A, Scharfenberg K, Schuff-Werner P. Prevalence of EDTA-anticoagulation associated platelet agglutination in a large outpatient laboratory: specificity and sensitivity of Sysmex XE 5000 flagging for platelet aggregates. Int J Lab Hematol. 2019; 41(Suppl. 2): 108. https://doi.org/10.1111/ijlh.13105
- 7Deng J, Chen Y, Zhang S, Li L, Shi Q, Liu M, et al. Mindray SF-cube technology: an effective way for correcting platelet count in individuals with EDTA dependent pseudo thrombocytopenia. Clin Chim Acta. 2020; 502: 99–101.
- 8Lunde HE, Hjelmtvedt AN, Amundsen EK. The diagnostic accuracy of Sysmex XN for identification of pseudothrombocytopenia using various thresholds for definition of platelet aggregation. Int J Lab Hematol. 2022; 44(5): 854–860.