Volume 193, Issue 3 pp. 633-636

Short Report

Kidney iron deposition by R2* is associated with haemolysis and urinary iron

Christopher C. Denton,

Christopher C. Denton

orcid.org/0000-0003-3070-1775

Department of Pediatrics, Divisions of Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

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Jon A. Detterich,

Jon A. Detterich

orcid.org/0000-0002-2086-9569

Department of Pediatrics, Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

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Thomas D. Coates,

Thomas D. Coates

orcid.org/0000-0001-9878-6029

Department of Pediatrics, Divisions of Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

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John C. Wood,

Corresponding Author

John C. Wood

[email protected]

orcid.org/0000-0003-0996-3439

Department of Pediatrics, Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence: John C Wood, MD, PhD, Children’s Hospital Los Angeles, 4650 Sunset Blvd, MS #34, Los Angeles, CA 90027.

Email: [email protected]

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Christopher C. Denton,

Christopher C. Denton

orcid.org/0000-0003-3070-1775

Department of Pediatrics, Divisions of Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Search for more papers by this author

Jon A. Detterich,

Jon A. Detterich

orcid.org/0000-0002-2086-9569

Department of Pediatrics, Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

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Thomas D. Coates,

Thomas D. Coates

orcid.org/0000-0001-9878-6029

Department of Pediatrics, Divisions of Hematology/Oncology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Search for more papers by this author

John C. Wood,

Corresponding Author

John C. Wood

[email protected]

orcid.org/0000-0003-0996-3439

Department of Pediatrics, Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, USA

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence: John C Wood, MD, PhD, Children’s Hospital Los Angeles, 4650 Sunset Blvd, MS #34, Los Angeles, CA 90027.

Email: [email protected]

Search for more papers by this author

First published: 20 November 2020

https://doi.org/10.1111/bjh.17085

Citations: 2

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Summary

Kidney iron deposition measured by R2* (magnetic resonance imaging) MRI is posited to result from tubular reabsorption of filtered haemoglobin due to intravascular haemolysis. In chronically transfused sickle cell disease (SCD), R2* is elevated and positively correlated with lactate dehydrogenase (LDH). To account for contributions to renal iron from systemic iron overload, we evaluated kidney R2*, urinary iron and haemolysis markers in 62 non-transfused SCD patients. On multivariate analysis, kidney R2* was associated with urinary iron and LDH (R² = 0·55, P < 0·0001). Our study confirms that kidney R2* is associated with intravascular haemolysis and raises important questions regarding the role of iron in SCD nephropathy.

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Volume193, Issue3

May 2021

Pages 633-636

Kidney iron deposition by R2* is associated with haemolysis and urinary iron

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Kidney iron deposition by R2* is associated with haemolysis and urinary iron

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