Psychosocial factors associated with impact of cancer in longterm haematological cancer survivors
Corresponding Author
Ania Korszun
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Correspondence: Professor Ania Korszun, Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
E-mail: [email protected]
Search for more papers by this authorShah-Jalal Sarker
Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, UK
Search for more papers by this authorKashfia Chowdhury
Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, UK
Search for more papers by this authorCharlotte Clark
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Search for more papers by this authorPaul Greaves
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorRachel Johnson
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorJudith Kingston
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorGill Levitt
Oncology, Great Ormond Street Hospital Trust, London, UK
Search for more papers by this authorJanet Matthews
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorPeter White
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Search for more papers by this authorAndrew Lister
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorJohn Gribben
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorCorresponding Author
Ania Korszun
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Correspondence: Professor Ania Korszun, Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
E-mail: [email protected]
Search for more papers by this authorShah-Jalal Sarker
Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, UK
Search for more papers by this authorKashfia Chowdhury
Centre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, London, UK
Search for more papers by this authorCharlotte Clark
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Search for more papers by this authorPaul Greaves
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorRachel Johnson
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorJudith Kingston
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorGill Levitt
Oncology, Great Ormond Street Hospital Trust, London, UK
Search for more papers by this authorJanet Matthews
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorPeter White
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
Search for more papers by this authorAndrew Lister
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorJohn Gribben
Centre for Haemato-Oncology, Barts Cancer Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Search for more papers by this authorSummary
To assess the impact of cancer (IOC) on subsequent quality of life (QOL), 718 long-term haematological cancer survivors completed validated psychosocial, functional and QOL scales, including IOC. Fifteen percent reported significant psychological distress, 18% high levels of fatigue and 10% moderate to severe functional impairment. These groups of participants also showed poorer QOL. There were no significant differences in psychological distress (P = 0·76), fatigue (P = 0·23) or functional impairment (P = 0·74) across different cancer subtypes. Two separate hierarchical regression analyses examined the combined association of disease-type, psychosocial and other factors on negative and positive IOC scores respectively. Higher negative IOC scores were significantly associated (P ≤ 0·001) with medical comorbidity, psychological distress, lower social support, high fatigue levels and functional impairment. Paediatric patients (diagnosed at <17 years) had significantly higher negative IOC scores than adult patients (P = 0·001); greater years since diagnosis was significantly (P < 0·001) associated with less negative IOC. Higher positive IOC was associated with acute leukaemia (P = 0·01); lower positive IOC with paediatric patients (P < 0·001), white ethnicity (P < 0·001), higher education (P = 0·003), no partner (P = 0·01) and lower social support (P = 0·01). Screening for medical comorbidity, psychological distress and fatigue identifies those needing most support and should allow earlier interventions to address negative and positive IOC to improve the well-being of cancer survivors.
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