Volume 125, Issue 12 pp. 1056-1062
Review Article

Angiogenesis in Schistosoma haematobium-associated urinary bladder cancer

Anderson Dematei

Anderson Dematei

Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal

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Rúben Fernandes

Rúben Fernandes

Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Instituto Politécnico do Porto, Porto, Portugal

I3S, Instituto de Investigação e Inovação da Universidade do Porto, Porto, Portugal

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Raquel Soares

Raquel Soares

I3S, Instituto de Investigação e Inovação da Universidade do Porto, Porto, Portugal

Departamento de Biomedicina, Unidade de Bioquímica, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

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Helena Alves

Helena Alves

Department of Health Promotion and Chronic Diseases, INSA – National Institute of Health Dr. Ricardo Jorge, Porto, Portugal

Fundação Professor Ernesto Morais, Porto, Portugal

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Joachim Richter

Joachim Richter

Institute of Tropical Medicine and International Health, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Monica C. Botelho

Corresponding Author

Monica C. Botelho

I3S, Instituto de Investigação e Inovação da Universidade do Porto, Porto, Portugal

Department of Health Promotion and Chronic Diseases, INSA – National Institute of Health Dr. Ricardo Jorge, Porto, Portugal

Mónica C. Botelho, Department of Health Promotion and Chronic Diseases, INSA – National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano 321, Porto 4000-055, Portugal. e-mails: [email protected]; [email protected]Search for more papers by this author
First published: 28 September 2017
Citations: 24

Abstract

Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood vessels from preexisting ones and is recognized as a key event in cell proliferation and carcinogenesis and spread of malignant lesions. A growing amount of evidence points to angiogenesis playing a key role in schistosomiasis-associated bladder cancer. Thus, identifying biomarkers of this process plays an important role in the study of cancer. Here, we review recent findings on the role of angiogenesis in bladder cancer and the growth factors that induce and assist in their development, particularly SCC of the bladder associated to urogenital schistosomiasis.

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