Influence of cognitive function on cerebrovascular disease among the elderly
J. Guo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorF. Sun
Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorL. Tao
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorY. Luo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorL. Liu
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorK. Cao
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorH. Li
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorCorresponding Author
Z. Tang
Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, Beijing, China
Z. Tang, Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng Dist, Beijing 100053, China
Tel.: +86 13910673595
Fax: +86 21 64085875
e-mail: [email protected]
and
X. Guo, School of Public Health, Capital Medical University, No. 10, Xitoutiao, Youanmen Wai, Fengtai Dist, Beijing 100069, China
Tel.: +86 13370173546
Fax: +86 21 64085875
e-mail: [email protected]
Search for more papers by this authorCorresponding Author
X. Guo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Z. Tang, Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng Dist, Beijing 100053, China
Tel.: +86 13910673595
Fax: +86 21 64085875
e-mail: [email protected]
and
X. Guo, School of Public Health, Capital Medical University, No. 10, Xitoutiao, Youanmen Wai, Fengtai Dist, Beijing 100069, China
Tel.: +86 13370173546
Fax: +86 21 64085875
e-mail: [email protected]
Search for more papers by this authorJ. Guo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorF. Sun
Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, Beijing, China
Search for more papers by this authorL. Tao
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorY. Luo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorL. Liu
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorK. Cao
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorH. Li
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Search for more papers by this authorCorresponding Author
Z. Tang
Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, Beijing, China
Z. Tang, Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng Dist, Beijing 100053, China
Tel.: +86 13910673595
Fax: +86 21 64085875
e-mail: [email protected]
and
X. Guo, School of Public Health, Capital Medical University, No. 10, Xitoutiao, Youanmen Wai, Fengtai Dist, Beijing 100069, China
Tel.: +86 13370173546
Fax: +86 21 64085875
e-mail: [email protected]
Search for more papers by this authorCorresponding Author
X. Guo
School of Public Health, Capital Medical University, Beijing, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China
Z. Tang, Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, No. 45, Changchun Street, Xicheng Dist, Beijing 100053, China
Tel.: +86 13910673595
Fax: +86 21 64085875
e-mail: [email protected]
and
X. Guo, School of Public Health, Capital Medical University, No. 10, Xitoutiao, Youanmen Wai, Fengtai Dist, Beijing 100069, China
Tel.: +86 13370173546
Fax: +86 21 64085875
e-mail: [email protected]
Search for more papers by this authorAbstract
Objectives
To determine the interrelationships between baseline Mini-Mental State Examination (MMSE) score and overall long-term risk of cerebrovascular disease (CBVD).
Materials & methods
This was a prospective cohort study of subjects aged 55 years or more who were enrolled in the Beijing Longitudinal Study of Aging (BLSA) and had a baseline MMSE score available. Baseline MMSE score was divided into four categories: ≥28, 26–27, 23–25, and ≤22. Participants were followed for 23 years. Cox regression models were used to examine the association between MMSE score and CBVD.
Results
A total of 2101 participants were included in this analysis, 335 (15.9%) with an MMSE score ≥28, 365 (17.4%) with a score of 26–27, 579 (27.6%) with a score of 23–25, and 822 (7.4%) with a score ≤22. There were 576 cases of CBVD. The overall risk of CBVD increased with decreasing MMSE score. The impact of MMSE score on the risk of CBVD was much stronger in women than in men. The hazard ratio for CBVD risk was 1.76 (95% confidence interval [CI], 1.29–2.39, P < 0.05) for subjects with an MMSE score ≤22, and 1.21 (95% CI, 0.91–1.61, P < 0.05) for those with an MMSE score of 23–25. Higher MMSE scores were less strongly associated with the risk of CBVD.
Conclusions
Elderly people with lower MMSE scores, especially women, are at higher long-term risk of CBVD.
Supporting Information
| Filename | Description |
|---|---|
| ane12599-sup-0001-TableS1-S3.docxWord document, 25.4 KB | Table S1. Risk of cerebrovascular disease (expressed as hazard ratios and 95% confidence intervals) categorized according to the MMSE score, calculated using different models. Table S2. Risk of cerebrovascular disease (expressed as hazard ratios and 95% confidence intervals) in males and females categorized according to the MMSE score, calculated using different models. Table S3. Characteristics between enrolled subjects and omitted subjects. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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