INVITED REVIEW
Reactive oxygen species impact on sperm DNA and its role in male infertility
A. D. Bui,
R. Sharma,
R. Henkel,
A. Agarwal,
A. D. Bui
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA
Search for more papers by this authorR. Sharma
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Search for more papers by this authorR. Henkel
Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa
Search for more papers by this authorCorresponding Author
A. Agarwal
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Correspondence
Ashok Agarwal, American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Email: [email protected]
Search for more papers by this authorA. D. Bui,
R. Sharma,
R. Henkel,
A. Agarwal,
A. D. Bui
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Ohio University Heritage College of Osteopathic Medicine, Athens, OH, USA
Search for more papers by this authorR. Sharma
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Search for more papers by this authorR. Henkel
Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa
Search for more papers by this authorCorresponding Author
A. Agarwal
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
Correspondence
Ashok Agarwal, American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Email: [email protected]
Search for more papers by this authorSummary
Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility. Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative stress (OS), which in turn can lead to nuclear and mitochondrial DNA damage, telomere shortening, epigenetic alterations and Y chromosomal microdeletions. In this review, we discuss how OS induces DNA damage and the types of DNA damage that can occur. We also briefly touch on the clinical consequences of OS-induced DNA damage.
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