Volume 58, Issue 7 pp. 851-857
GENERAL ANAESTHESIA

Umbilical cord blood acid–base status in pregnancy with congenital heart disease

Q. ZHAN

Q. ZHAN

Department of Anesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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X. WANG

Corresponding Author

X. WANG

Department of Anesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Address:

Xiangrui Wang

Department of Anesthesia

Shanghai Renji Hospital

Jiaotong University

1630 Dongfang Road

Shanghai 200127

China

e-mail: [email protected]

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J. YU

J. YU

Department of Anesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Y. FAN

Y. FAN

Department of Anesthesia, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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First published: 24 June 2014
Citations: 1

Abstract

Background

The risk of fetal and neonatal complications is higher in pregnant women with congenital heart disease (CHD). It remains unknown whether umbilical cord blood gas values are different between pregnant women with CHD and healthy women undergoing elective cesarean section during combined spinal-epidural anesthesia. The purpose of the present study was to compare umbilical cord blood acid–base status and gas values in pregnant women with CHD vs. healthy pregnant women undergoing elective cesarean section during combined spinal–epidural (CSE) anesthesia.

Methods

Patients with singleton pregnancy undergoing elective cesarean delivery under CSE anesthesia were enrolled. Patients were divided into two groups: healthy pregnant women (group H) and pregnant with congenital heart disease (group CHD). Immediately after delivery, umbilical cord arterial blood sample and venous blood sample were collected and measured. The comparison between two groups was performed using grouped t-test.

Results

Forty-four women in group H and 33 women in group CHD were analyzed finally. Umbilical arterial blood pH, base excess (BE) and HCO3 (pH 7.29 ± 0.05, BE −1.4 ± 1.9 mmol/L, HCO3 21.5 ± 1.4 mmol/L) were significantly lower in pregnant women with CHD than in healthy pregnant women (pH 7.33 ± 0.03, BE −0.1 ± 2.1 mmol/L, HCO3 22.5 ± 1.4 mmol/L).

Conclusions

The lower values of umbilical arterial blood pH, BE and HCO3 were observed in pregnant women with CHD than in healthy women undergoing elective cesarean section during CSE anesthesia.

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