REVIEW
Role of hydrogels in osteoarthritis: A comprehensive review
Yuan Xu,
Jing-Yan Wang,
Tian Meng,
Xue-Wei Ma,
Hao Li,
Kai Li,
Corresponding Author
Yuan Xu
College of Health Industry, Sichuan Tourism University, Chengdu, China
Correspondence
Yuan Xu, College of Health Industry, Sichuan Tourism University, 459 Hongling Road, Chengdu, 610100, Sichuan, China.
Email: [email protected]
Search for more papers by this authorJing-Yan Wang
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorTian Meng
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorXue-Wei Ma
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorHao Li
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorKai Li
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorYuan Xu,
Jing-Yan Wang,
Tian Meng,
Xue-Wei Ma,
Hao Li,
Kai Li,
Corresponding Author
Yuan Xu
College of Health Industry, Sichuan Tourism University, Chengdu, China
Correspondence
Yuan Xu, College of Health Industry, Sichuan Tourism University, 459 Hongling Road, Chengdu, 610100, Sichuan, China.
Email: [email protected]
Search for more papers by this authorJing-Yan Wang
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorTian Meng
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorXue-Wei Ma
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorHao Li
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorKai Li
College of Health Industry, Sichuan Tourism University, Chengdu, China
Search for more papers by this authorYuan Xu and Jing-Yan Wang contributed equally to this study.
Abstract
Osteoarthritis (OA) is a chronic, degenerative, and age-related disease. It is characterized by chronic inflammation, progressive articular cartilage destruction, and subchondral bone sclerosis. The current effective treatment for OA is limited. Hydrogel is a kind of unique carrier with well-known biocompatibility, softness, and high water content among various biomaterials. Hydrogels are developed for different biomedical applications, for instance, drug delivery, and tissue engineering. To date, a variety of hydrogels-based therapies have been used in OA patients or animal models. In this review, we comprehensively summarized the potential role of hydrogels in chondrocytes proliferation, apoptosis, and inflammatory component production and discussed the impact of hydrogels on OA development. The collection of this information will help better understand the present progress of hydrogels in OA.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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