Potential utility of anti-TNF drugs in synovial chondromatosis associated with ankylosing spondylitis
Shengyan Yu
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorMeifang Wu
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorGengmin Zhou
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorTatsuya Ishikawa
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorJianle Liang
Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorDhiraj Nallapothula
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorCorresponding Author
Ram Raj Singh
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Qingwen Wang
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Meiying Wang
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorShengyan Yu
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorMeifang Wu
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorGengmin Zhou
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorTatsuya Ishikawa
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorJianle Liang
Department of Medical Imaging, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorDhiraj Nallapothula
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Search for more papers by this authorCorresponding Author
Ram Raj Singh
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Qingwen Wang
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Meiying Wang
Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, China
Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA
Correspondence
Meiying Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Qingwen Wang, Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Email: [email protected]
Ram Raj Singh, Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Email: [email protected]
Search for more papers by this authorAbstract
We describe a previously unreported association of ankylosing spondylitis with synovial chondromatosis, and briefly review previously reported cases and treatment of synovial chondromatosis in patients with other immune-mediated inflammatory arthritides. A 20-year-old man with ankylosing spondylitis whose axial disease was in remission with nonsteroidal anti-inflammatory drugs and oral disease-modifying anti-rheumatic drugs developed recurrent right knee pain and swelling. Magnetic resonance imaging of his right knee revealed calcified loose bodies, suggestive of synovial chondromatosis. While waiting for the surgical intervention and other invasive therapy previously reported in patients with synovial chondromatosis, a trial of etanercept eliminated the pain and swelling of the knee; however, the loose bodies have persisted during the 2-year follow-up. Thus, synovial chondromatosis should be considered in the differential diagnoses of a refractory monoarticular pain and swelling in patients with otherwise controlled inflammatory arthritis. Our report advocates a trial of anti-tumor necrosis factor drugs, which might delay the need for invasive therapy in patients with synovial chondromatosis.
CONFLICTS OF INTEREST
The authors declare no conflicts of interest. This report has not been submitted for publication and has not been published in whole or in part elsewhere.
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