Successful treatment with spesolimab for generalized pustular psoriasis in an elderly patient with TRPM4 mutation
Daniel Meng-Yen Hsieh
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Search for more papers by this authorPanpan Shang
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Search for more papers by this authorYusi Gao
Department of Cardiology, Peking University First Hospital, Beijing, China
Search for more papers by this authorCorresponding Author
Jiahui Zhao
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Correspondence
Jiahui Zhao, Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, No. 8 Xishiku St., Xicheng District, Beijing 100034, China.
Email: [email protected]
Search for more papers by this authorDaniel Meng-Yen Hsieh
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Search for more papers by this authorPanpan Shang
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Search for more papers by this authorYusi Gao
Department of Cardiology, Peking University First Hospital, Beijing, China
Search for more papers by this authorCorresponding Author
Jiahui Zhao
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China
Correspondence
Jiahui Zhao, Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, No. 8 Xishiku St., Xicheng District, Beijing 100034, China.
Email: [email protected]
Search for more papers by this author
REFERENCES
- 1Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP. J Dermatol. 2018; 45: 1235–1270.
- 2Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, et al. Trial of spesolimab for generalized pustular psoriasis. N Engl J Med. 2021; 385: 2431–2440.
- 3Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, et al. Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 2011; 365: 620–628.
- 4Wang H, Xu Z, Lee BH, Vu S, Hu L, Lee M, et al. Gain-of-function mutations in TRPM4 activation gate cause progressive symmetric erythrokeratodermia. J Invest Dermatol. 2019; 139: 1089–1097.
- 5Akiyama M. Pustular psoriasis as an autoinflammatory keratinization disease (AiKD): genetic predisposing factors and promising therapeutic targets. J Dermatol Sci. 2022; 105: 11–17.
