Individual joints involvement pattern in psoriatic arthritis: A cross-sectional study in China
Jiashuai Li
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorJingge Xiao
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorXiaoyun Xie
Department of rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Search for more papers by this authorSichun Deng
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorGuo Zhou
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorRuixuan Wang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorQianzi Liu
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorMi Zhang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Mingliang Chen
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Junchen Chen
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Yehong Kuang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorJiashuai Li
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorJingge Xiao
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorXiaoyun Xie
Department of rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Search for more papers by this authorSichun Deng
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorGuo Zhou
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorRuixuan Wang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorQianzi Liu
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorMi Zhang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Search for more papers by this authorCorresponding Author
Mingliang Chen
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Junchen Chen
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Yehong Kuang
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China
Furong Laboratory, Changsha, Hunan, China
National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, China
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Changsha, Hunan, China
Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Changsha, Hunan, China
Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China
Correspondence
Mingliang Chen, Junchen Chen and Yehong Kuang, Department of Dermatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410000, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorJiashuai Li and Jingge Xiao have contributed equally to this work and share the first authorship.
Mingliang Chen, Junchen Chen and Yehong Kuang have contributed equally to this work and share corresponding authorship.
Abstract
Psoriatic arthritis (PsA) is characterized by multi-joint involvement, primarily affecting the small joints in the hands and feet. However, the specific pattern of joint involvement at an individual level remains uncertain. This study aimed to elucidate the pattern of joint involvement in a PsA cohort. Patients diagnosed with PsA were recruited for this cross-sectional study. Demographic, clinical, laboratory, personal and family history, and comorbidity data were collected. Descriptive statistical analysis was performed, and univariate and multivariate regression models were used to examine baseline factors influencing joint involvement. A total of 264 PsA patients (156 males) were included in the study. The results revealed a predominant involvement of peripheral facet joints. The second proximal interphalangeal joint (PIP) of the right hand exhibited the highest prevalence of swelling (18.9%), while the right knee joint had the highest prevalence of tenderness (24.2%). Older age and earlier onset of PsA were identified as independent factors associated with the swelling of the second PIP of the right hand. Older age, earlier onset of PsA, lower Psoriasis Area and Severity Index and higher Dermatology Life Quality Index scores were identified as independent factors associated with the tenderness of the right knee joint. In conclusion, the most commonly affected joints in PsA are the second PIP of the right hand and the right knee joint.
CONFLICT OF INTEREST STATEMENT
None declared.
Open Research
DATA AVAILABILITY STATEMENT
The original datasets used for analysis in the current study can be provided on reasonable request by contacting the corresponding author.
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