Low Mean Nocturnal Baseline Impedance is Associated With a Pathological Acid Exposure Time in Children
Yolainis Rosado-Arias
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorCorresponding Author
Erick Manuel Toro-Monjaraz
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Address correspondence and reprint requests to Erick Manuel Toro-Monjaraz, Insurgentes Sur 3700 C Colonia Insurgentes-Cuicuilco CP 04300, Mexico (e-mail: [email protected]).Search for more papers by this authorRoberto Cervantes-Bustamante
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorFlora Zarate-Mondragon
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorJose Cadena-Leon
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorKaren Ignorosa-Arellano
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorAlejandro Loredo-Mayer
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorJaime Ramírez-Mayans
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorYolainis Rosado-Arias
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorCorresponding Author
Erick Manuel Toro-Monjaraz
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Address correspondence and reprint requests to Erick Manuel Toro-Monjaraz, Insurgentes Sur 3700 C Colonia Insurgentes-Cuicuilco CP 04300, Mexico (e-mail: [email protected]).Search for more papers by this authorRoberto Cervantes-Bustamante
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorFlora Zarate-Mondragon
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorJose Cadena-Leon
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorKaren Ignorosa-Arellano
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorAlejandro Loredo-Mayer
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorJaime Ramírez-Mayans
Departement of Gastroenterology, Nutrition Department, Instituto Nacional de Pediatria, Mexico, Mexico
Search for more papers by this authorThis article has been developed as a Journal CME and MOC Part II Activity by NASPGHAN. Visit https://learnonline.naspghan.org/ to view instructions, documentation, and the complete necessary steps to receive CME and MOC credits for reading this article.
The authors report no conflicts of interest.
ABSTRACT
Background:
The baseline impedance (BI) and the mean nocturnal baseline impedance (MNBI) serve as markers of mucosal integrity in patients with pathologic acid exposure time (AET). This work aims to investigate the association between the BI and MNBI with the AET in children.
Methodology:
A retrospective study was performed in children ⩽18 years old with suspicion of gastroesophageal reflux disease who underwent both endoscopy and pH-impedance monitoring (pH-MII). Esophagitis was graded according to the Los Angeles classification. The pathological AET was determined depending on the age (≥5% in patients >1 year and ≥10% in those ages ⩽1 year). For the BI, 60 s measurements were taken every 4 h, and for the MNBI, 3 10 min measurements were taken between 1.00 and 3:00 AM; then, they were averaged. The means of BI and MNBI were compared with each other, with the AET, and other variables.
Results:
Sixty-eight patients were included, 25% of patients presented pathological AET. The mean of the MNBI was higher than BI in channels 6 (2195 vs 1997 Ω, P = 0.011) and 5 (2393 vs 2228 Ω, P = 0.013). BI and MNBI at channel 6 were lower in patients with pathological AET than in those with normal AET (1573 vs 2138 Ω, P = 0.007) and (1592 vs 2396 Ω, P = 0.004), respectively.
Conclusions:
Children with pathological AET had lower impedance values than those with normal AET. BI and MNBI measurements should be part of the routine MII-pH assessment in children.
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