Volume 112, Issue 6 pp. 1084-1088

Article

Inducible Nitric Oxide Synthase Expression in Pharyngeal Squamous Cell Carcinoma: Relation to p53 Expression, Clinicopathological Data, and Survival^†

Matti J. Pukkila MD,

Matti J. Pukkila MD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Jari K. Kellokoski DDS, PhD,

Jari K. Kellokoski DDS, PhD

Oral and Maxillofacial Unit, University of Kuopio, Kuopio, Finland.

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Jukka A. Virtaniemi MD, PhD,

Jukka A. Virtaniemi MD, PhD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Eero J. Kumpulainen MD,

Eero J. Kumpulainen MD

Department of Oncology, University of Kuopio and Kuopio University Hospital, Finland.

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Risto T. Johansson MD, PhD,

Risto T. Johansson MD, PhD

Department of Oncology, University of Kuopio and Kuopio University Hospital, Finland.

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Pirjo M. Halonen MSc,

Pirjo M. Halonen MSc

Computing Centre, University of Kuopio, Kuopio, Finland.

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Ari S. T. Kosunen MD,

Ari S. T. Kosunen MD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Juhani Nuutinen MD, PhD,

Juhani Nuutinen MD, PhD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Veli-Matti Kosma MD, PhD,

Corresponding Author

Veli-Matti Kosma MD, PhD

[email protected]

Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Finland.

Veli-Matti Kosma, MD, PhD, Department of Pathology and Forensic Medicine, University of Kuopio, Post Office Box 1627, FIN 70211 Kuopio, Finland, EU.Search for more papers by this author

Matti J. Pukkila MD,

Matti J. Pukkila MD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Jari K. Kellokoski DDS, PhD,

Jari K. Kellokoski DDS, PhD

Oral and Maxillofacial Unit, University of Kuopio, Kuopio, Finland.

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Jukka A. Virtaniemi MD, PhD,

Jukka A. Virtaniemi MD, PhD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Eero J. Kumpulainen MD,

Eero J. Kumpulainen MD

Department of Oncology, University of Kuopio and Kuopio University Hospital, Finland.

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Risto T. Johansson MD, PhD,

Risto T. Johansson MD, PhD

Department of Oncology, University of Kuopio and Kuopio University Hospital, Finland.

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Pirjo M. Halonen MSc,

Pirjo M. Halonen MSc

Computing Centre, University of Kuopio, Kuopio, Finland.

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Ari S. T. Kosunen MD,

Ari S. T. Kosunen MD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Juhani Nuutinen MD, PhD,

Juhani Nuutinen MD, PhD

Department of Otolaryngology—Head and Neck Surgery, University of Kuopio and Kuopio University Hospital, Finland.

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Veli-Matti Kosma MD, PhD,

Corresponding Author

Veli-Matti Kosma MD, PhD

[email protected]

Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Finland.

Veli-Matti Kosma, MD, PhD, Department of Pathology and Forensic Medicine, University of Kuopio, Post Office Box 1627, FIN 70211 Kuopio, Finland, EU.Search for more papers by this author

First published: 02 January 2009

https://doi.org/10.1097/00005537-200206000-00027

Citations: 14

^†

Supported by Kuopio University Hospital EVO funds and by Northern Savo Cancer Fund.

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Abstract

Objective To investigate the expression of inducible nitric oxide synthase (iNOS) in oropharyngeal and hypopharyngeal squamous cell carcinoma (SCC) and its relation to p53 expression, histologic differentiation, clinical data, and prognosis.

Study Design A retrospective survey.

Methods Primary tumors for analyses were obtained from 118 patients diagnosed with SCC of the oropharynx or hypopharynx between 1975 and 1998 in eastern Finland. Immunohistochemical analysis was used to evaluate the expression of iNOS and p53. The expression pattern of iNOS was related to p53 expression, clinical data, and survival.

Results High iNOS score was associated significantly with high nuclear p53 expression index (P = .006) and positive cytoplasmic p53 expression (P =.025). The score for iNOS expression was significantly lower in the largest (T4) tumors (P = .043). No association was seen between iNOS score and N or M class, tumor stage, or histologic differentiation. The score for iNOS expression was not related to overall survival.

Conclusions The expressions of iNOS and p53 seem to be inter-related in pharyngeal SCC, although the causality remains to be clarified. The expression of iNOS shows no prognostic value in pharyngeal SCC.

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Volume112, Issue6

June 2002

Pages 1084-1088

Inducible Nitric Oxide Synthase Expression in Pharyngeal Squamous Cell Carcinoma: Relation to p53 Expression, Clinicopathological Data, and Survival^†

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Inducible Nitric Oxide Synthase Expression in Pharyngeal Squamous Cell Carcinoma: Relation to p53 Expression, Clinicopathological Data, and Survival†

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Inducible Nitric Oxide Synthase Expression in Pharyngeal Squamous Cell Carcinoma: Relation to p53 Expression, Clinicopathological Data, and Survival^†