Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: Implications for management
Corresponding Author
Ben Christopher Reynolds
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Ben C. Reynolds, Paediatric Department, Queen Mother's Hospital, Yorkhill Division, 38 Dalnair Street, Glasgow, G3 8SJ, UK. Tel: +44 (0)141 201 1000. Mobile: +44 (0)777 929 5467. E-mail: [email protected]Search for more papers by this authorJudith Helen Simpson
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Search for more papers by this authorLena Macara
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Search for more papers by this authorAndrew James Bruce Watt
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorHaytham Kubba
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorMalcolm David Cairns Donaldson
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorJoachim Pohlen
Department of Pediatrics, Johannes Gutenburg University Medical School. Mainz. Germany
Search for more papers by this authorCorresponding Author
Ben Christopher Reynolds
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Ben C. Reynolds, Paediatric Department, Queen Mother's Hospital, Yorkhill Division, 38 Dalnair Street, Glasgow, G3 8SJ, UK. Tel: +44 (0)141 201 1000. Mobile: +44 (0)777 929 5467. E-mail: [email protected]Search for more papers by this authorJudith Helen Simpson
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Search for more papers by this authorLena Macara
Yorkhill Division, Queen Mother's Hospital. Glasgow. UK
Search for more papers by this authorAndrew James Bruce Watt
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorHaytham Kubba
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorMalcolm David Cairns Donaldson
Yorkhill Division, Royal Hospital for Sick Children. Glasgow. UK
Search for more papers by this authorJoachim Pohlen
Department of Pediatrics, Johannes Gutenburg University Medical School. Mainz. Germany
Search for more papers by this authorAbstract
We report a twin pregnancy complicated by fetal goitrous hypothyroidism secondary to dyshormonogenesis caused by thyroglobulin deficiency. Antenatal treatment with intra-amniotic thyroxine was considered but not performed, given the late gestational age at diagnosis and the multiple nature of the pregnancy. Both twins developed airway obstruction at delivery, requiring intubation and ventilation. We review the literature and describe the practical issues relating to the antenatal assessment and perinatal management of fetal goitre.
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