Somatotropic axis derangement as an underlying factor in the genesis of retinopathy of prematurity
Melinda Y. Yeung,
Corresponding Author
Melinda Y. Yeung
Department of Pharmacy, The Children's Hospital at Westmead, New South Wales, Australia
Melinda Yeung, Department of Pharmacy, The Children's Hospital at Westmead, Cr Hawkesbury and Hainsworth Roads, Westmead, New South Wales 2145, Australia. Tel: +61 2 9845 2708. Fax: +61 2 9845 2709. E-mail: [email protected]Search for more papers by this authorMelinda Y. Yeung,
Corresponding Author
Melinda Y. Yeung
Department of Pharmacy, The Children's Hospital at Westmead, New South Wales, Australia
Melinda Yeung, Department of Pharmacy, The Children's Hospital at Westmead, Cr Hawkesbury and Hainsworth Roads, Westmead, New South Wales 2145, Australia. Tel: +61 2 9845 2708. Fax: +61 2 9845 2709. E-mail: [email protected]Search for more papers by this authorAbstract
Recent research data suggest a significant role of prolonged low serum insulin-like growth factor (IGF)-I concentration in the genesis of retinopathy of prematurity (ROP). Evidence also reveals significant early postnatal nutritional deficits and growth deceleration among premature newborns.
Conclusion. Since serum IGF-I concentration is positively related to nutritional status, particularly protein nutrition, it would suggest that protein under-nutrition may be a major determinant of low serum IGF-I concentration and in the high risk of ROP.
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