Lipoprotein(a) Concentration Increases during Treatment with Carbamazepine

Summary: Purpose: Treatment with carbamazepine (CBZ) is known to affect apolipoprotein B–containing lipoprotein concentrations in serum. However, little is known about the effects of anticonvulsant drugs (AEDs) on lipoprotein(a) [Lp(a)], although Lp(a) has been characterized as independent cardiovascular risk factor. We investigated prospectively the effect of CBZ on lipoprotein(a) concentration in normolipidemic healthy adults.

Methods: Twenty male volunteers were included in the study. Lp(a) levels were determined before and 69 ± 19 days after CBZ administration by using an enzyme-linked immunoassay.

Results: CBZ (mean plasma concentration, 6.6 ± 0.6 μg/ml) caused a significant increase in Lp(a) concentrations, with a median change of +19.5% (95% CI: +8.2, +53.3; p < 0.001). Total cholesterol, low density lipoprotein (LDL) cholesterol, and triglycerides also increased significantly.

Conclusions: Although the precise mechanism of action of CBZ on Lp(a) elevation remains uncertain, it might be related to its enzyme-inducing properties. During treatment with CBZ, special focus should be given to elevated LDL cholesterol and Lp(a) concentrations with regard to increased risk for atherosclerotic vascular diseases.