Special Feature: Dendritic Cell
Chemokines and dendritic cells: A crucial alliance
Shaun R McColl,
Shaun R McColl
Chemokine Biology Laboratory and Department of Molecular Biosciences, The University of Adelaide, Adelaide, Australia
Search for more papers by this authorShaun R McColl,
Shaun R McColl
Chemokine Biology Laboratory and Department of Molecular Biosciences, The University of Adelaide, Adelaide, Australia
Search for more papers by this authorDr Shaun McColl, Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia. Email: [email protected]
Abstract
Dendritic cells (DC) are bone marrow-derived professional antigen-presenting cells that function as sentinels of the immune system. Their importance in immunity resides in their unique ability to prime or tolerize T lymphocytes, thereby initiating or inhibiting immune responses. They reside in all tissues and organs and upon appropriate activation, migrate to secondary lymphoid organs to present antigen to T lymphocytes in the T cell zones. Because of this central role in T cell activation, there is a great deal of interest in using DC therapeutically to deliver positive or negative signals to the immune system. The DC system is critically dependent on the ability of DC at different stages of maturation to respond to a range of soluble and cell-bound signals, including members of the chemokine gene superfamily. This review will describe the interactions between DC and the chemokine system.
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