Successful induction of immune tolerance in a patient with haemophilia B with inhibitor
Dr N. Suzuki, Department of Pediatrics, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-Ku, Sapporo 060-8543, Japan. Tel.: +81 11 611 2111; fax: +81 11 611 0352; e-mail: [email protected]
Summary.
We describe successful induction of immune tolerance (IT) in a 10-month-old boy with severe haemophilia B. Urticaria developed soon after starting prophylactic treatment and was associated with an inhibitor at 7 Bethesda units mL−1. Initially, we tried low dose factor IX therapy to induce IT with only a transient effect. The patient experienced an intracranial haemorrhage. A simple bolus dose of FIX eradicated the inhibitor. Thereafter he has been free from inhibitor and nephrotic syndrome for more than 5 years, although he receives FIX three times a week.
