Gender-dependent specific immune response during chronic human Schistosomiasis haematobia
F. Remoué
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorD. To Van
Programme ESPOIR, Région Médicale de St-Louis, Saint-Louis, Sénégal,
Search for more papers by this authorA.-M. Schacht
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorM. Picquet
Laboratory of Parasitology, University of Gent, Merelbeke, Belgium and
Search for more papers by this authorO. Garraud
Unité d' Immunologie, Institut Pasteur de Dakar, Dakar, Sénégal
Search for more papers by this authorJ. Vercruysse
Laboratory of Parasitology, University of Gent, Merelbeke, Belgium and
Search for more papers by this authorA. Ly
Programme ESPOIR, Région Médicale de St-Louis, Saint-Louis, Sénégal,
Search for more papers by this authorA. Capron
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorG. Riveau
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorF. Remoué
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorD. To Van
Programme ESPOIR, Région Médicale de St-Louis, Saint-Louis, Sénégal,
Search for more papers by this authorA.-M. Schacht
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorM. Picquet
Laboratory of Parasitology, University of Gent, Merelbeke, Belgium and
Search for more papers by this authorO. Garraud
Unité d' Immunologie, Institut Pasteur de Dakar, Dakar, Sénégal
Search for more papers by this authorJ. Vercruysse
Laboratory of Parasitology, University of Gent, Merelbeke, Belgium and
Search for more papers by this authorA. Ly
Programme ESPOIR, Région Médicale de St-Louis, Saint-Louis, Sénégal,
Search for more papers by this authorA. Capron
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorG. Riveau
INSERM Unité 167, Institut Pasteur de Lille, Lille, France,
Search for more papers by this authorAbstract
The cellular and humoral acquired immune responses to Schistosoma haematobium 28 kD gluthathione S-Transferase (Sh28GST) antigen were evaluated in a Senegalese population chronically infected with S. haematobium parasite. We show a gender-dependent immune response in adult individuals presenting similar intensities of infection. Indeed, the specific IgA response and production of TGF-β and IL-10 were found significantly higher in females compared to males. In addition, we showed that this profile was combined with a weak production of Th1-related cytokines (TNFα and IFNγ) and was associated with an absence of proliferation to the antigen. A significantly higher Nuclear Matrix Protein 41/7 secretion, an apoptosis marker, was specifically observed in mononuclear blood cell cultures of females suggesting that a specific cell death process was engaged in a gender-dependent manner. This specific profile could be associated with the so-called T helper type-3 (Th3) immune response specifically promoting the production of IgA and would be developed upon the down-regulation of the specific Type-1 response by a probable cell death mechanism. This gender-dependent immune regulation, which may be under the influence of nonimmunological factors like sexual hormones, may be related to the chronicity of the infection.
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