Volume 124, Issue 4 pp. 421-432

Human herpesvirus 6 infection in hematopoietic stem cell transplant patients

Tetsushi Yoshikawa,

Tetsushi Yoshikawa

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

Search for more papers by this author

Tetsushi Yoshikawa,

Tetsushi Yoshikawa

Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

Search for more papers by this author

First published: 14 January 2004

https://doi.org/10.1046/j.1365-2141.2003.04788.x

Citations: 72

Tetsushi Yoshikawa, MD, Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. E-mail: [email protected]

Share a link

Email
Wechat
Bluesky

References

Agut, H., Collandre, H., Aubin, J.T., Guetard, D., Favier, V., Ingrand, D., Montagnier, L. & Huraux, J.M. (1989) In vitro sensitivity of human herpesvirus-6 to antiviral drugs. Research of Virology, 140, 219–228.
10.1016/S0923-2516(89)80099-8
CAS PubMed Web of Science® Google Scholar
Allen, U.D., Tellier, R., Doyle, J., Petric, M., Wasfy, S., Kumar, P., Calderwood, S., Freedman, M. & Saunders, F. (2001) The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a pilot study. Bone Marrow Transplantation, 28, 473–477.
10.1038/sj.bmt.1703153
CAS PubMed Web of Science® Google Scholar
Amo, K., Tanaka-Taya, K., Inagi, R., Miyagawa, H., Miyoshi, H., Okusu, I., Sashihara, J., Hara, J., Nakayama, M., Yamanishi, K. & Okada, S. (2003) Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clinical Infectious Diseases, 36, 120–123.
10.1086/345464
PubMed Web of Science® Google Scholar
Ansari, A. & Emery, V.C. (1999) The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses. Journal of Virology, 73, 3284–3291.
CAS PubMed Web of Science® Google Scholar
Appleton, A.L., Sviland, L., Peiris, J.S., Taylor, C.E., Wilkes, J., Green, M.A., Pearson, A.D., Kelly, P.J., Malcolm, A.J. & Proctor, S.J. (1995) Human herpesvirus 6 infection in marrow graft recipients: role in pathogenesis of graft-versus-host disease. Bone Marrow Transplantation, 16, 777–782.
PubMed Web of Science® Google Scholar
Asada, H., Klaus-Kovtun, V., Golding, H., Katz, S.I. & Blauvelt, A. (1999) Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures. Journal of Virology, 73, 4019–4028.
CAS PubMed Web of Science® Google Scholar
Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., Kondo, K. & Yamanishi, K. (1990) Fatal fulminant hepatitis in an infants with human herpesvirus-6 infection. Lancet, 335, 862–863.
10.1016/0140-6736(90)90983-C
PubMed Web of Science® Google Scholar
Asano, Y., Yoshikawa, T., Suga, S., Nakashima, T., Yazaki, T., Fukuda, M., Kojima, S. & Matsuyama, T. (1991) Reactivation of herpesvirus type 6 in children receiving bone marrow transplants for leukemia. New England Journal of Medicine, 324, 634–635.
10.1056/NEJM199102283240915
CAS PubMed Web of Science® Google Scholar
Asano, Y., Yoshikawa, T., Kajita, Y., Ogura, R., Suga, S., Yazaki, T., Nakashima, T., Yamada, A. & Kurata, T. (1992) Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection. Archives of Disease in Childhood, 67, 1484–1485.
10.1136/adc.67.12.1484
PubMed Web of Science® Google Scholar
Asano, Y., Yoshikawa, T., Suga, S., Kobayashi, I., Nakashima, T., Yazaki, T., Kajita, Y. & Ozaki, T. (1994) Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics, 93, 104–108.
10.1542/peds.93.1.104
CAS PubMed Web of Science® Google Scholar
Biberfeld, P., Kramarsky, B., Salahuddin, S.Z. & Gallo, R.C. (1987) Ultrastructural characterization of a new human B lymphotropic DNA virus (human herpesvirus 6) isolated from patients with lymphoproliferative disease. Journal of National Cancer Institute, 79, 933–941.
CAS PubMed Web of Science® Google Scholar
Bollen, A.E., Wartan, A.N., Krikke, A.P. & Haaxma-Reiche, H. (2001) Amnestic syndrome after lung transplantation by human herpes virus-6 encephalitis. Journal of Neurology, 248, 619–620.
10.1007/s004150170142
CAS PubMed Web of Science® Google Scholar
Bosi, A., Zazzi, M., Amantini, A., Cellerini, M., Vannucchi, A.M., De Milito, A., Guidi, S., Saccardi, R., Lombardini, L., Laszlo, D. & Rossi Ferrini, P. (1998) Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant. Bone Marrow Transplantation, 22, 285–288.
10.1038/sj.bmt.1701326
CAS PubMed Google Scholar
Boutolleau, D., Fernandez, C., Andre, E., Imbert-Marcille, B.M., Milpied, N., Agut, H. & Gautheret-Dejean, A. (2003) Human herpesvirus (HHV)-6 and HHV-7: two closely related viruses with different infection profiles in stem cell transplantation recipients. Journal of Infectious Diseases, 187, 179–186.
10.1086/367677
PubMed Web of Science® Google Scholar
Burns, W.H. & Sandford, G.R. (1990) Susceptibility of human herpesvirus 6 to antivirals in vitro. Journal of Infectious Diseases, 162, 634–637.
10.1093/infdis/162.3.634
PubMed Web of Science® Google Scholar
Carrigan, D.R. & Knox, K.K. (1994) Human herpesvirus 6 (HHV-6) isolation from bone marrow: HHV-6-associated bone marrow suppression in bone marrow transplant patients. Blood, 84, 3307–1370.
10.1182/blood.V84.10.3307.3307
CAS PubMed Web of Science® Google Scholar
Carrigan, D.R., Drobyski, W.R., Russler, S.K., Tapper, M.A., Knox, K.K. & Ash, R.C. (1991) Interstitial pneumonitis associated with human herpesvirus 6 infection after marrow transplantation. Lancet, 338, 147–149.
10.1016/0140-6736(91)90137-E
PubMed Web of Science® Google Scholar
Carrigan, D.R., Harrington, D. & Knox, K.K. (1996) Subacute leukoencephalitis caused by CNS infection with human herpesvirus-6 manifesting as acute multiple sclerosis. Neurology, 47, 145–148.
10.1212/WNL.47.1.145
CAS PubMed Web of Science® Google Scholar
Carvajal, E., Verdeguer, A., Fernandez, J.M., Canete, A. & Castel, V. (2001) Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation. Journal of Pediatric Hematology Oncology, 23, 626–628.
10.1097/00043426-200112000-00016
CAS PubMed Web of Science® Google Scholar
Cermelli, C., Berti, R., Soldan, S.S., Mayne, M., D'ambrosia, J.M., Ludwin, S.K. & Jacobson, S. (2003) High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection. Journal of Infectious Diseases, 187, 1377–1387.
10.1086/368166
CAS PubMed Web of Science® Google Scholar
Chik, K.W., Chan, P.K., Li, C.K., Shing, M.M., Lee, V., Cheng, A.F. & Yuen, P.M. (2002) Human herpesvirus-6 encephalitis after unrelated umbilical cord blood transplant in children. Bone Marrow Transplantation, 29, 991–994.
10.1038/sj.bmt.1703596
CAS PubMed Web of Science® Google Scholar
Cole, P.D., Stiles, J., Boulad, F., Small, T.N., O'Reilly, R.J., George, D., Szabolcs, P., Kiehn, T.E. & Kernan, N.A. (1998) Successful treatment of human herpesvirus 6 encephalitis in a bone marrow transplant recipient. Clinical Infectious Diseases, 27, 653–654.
10.1086/517145
CAS PubMed Web of Science® Google Scholar
Cone, R.W., Huang, M.L., Ashley, R. & Corey, L. (1993a) Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. Journal of Clinical Microbiology, 31, 1262–1267.
10.1128/jcm.31.5.1262-1267.1993
CAS PubMed Web of Science® Google Scholar
Cone, R.W., Hackman, R.C., Huang, M.L., Bowden, R.A., Meyers, J.D., Metcalf, M., Zeh, J., Ashley, R. & Corey, L. (1993b) Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. New England Journal of Medicine, 329, 156–161.
10.1056/NEJM199307153290302
PubMed Web of Science® Google Scholar
Cone, R.W., Huang, M.L.W., Corey, L., Zeh, J., Ashley, R. & Bowden, R. (1999) Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations. Journal of Infectious Diseases, 179, 311–318.
10.1086/314581
CAS PubMed Web of Science® Google Scholar
Cuomo, L., Trivedi, P., Cardillo, M.R., Gagliardi, F.M., Vecchione, A., Caruso, R., Calogero, A., Frati, L., Faggioni, A. & Ragona, G.A. (2001) Human herpesvirus 6 infection in neoplastic and normal brain tissue. Journal of Medical Virology, 63, 45–51.
10.1002/1096-9071(200101)63:1<45::AID-JMV1006>3.0.CO;2-K
CAS PubMed Web of Science® Google Scholar
Daibata, M., Taguchi, T., Taguchi, H. & Miyoshi, I. (1998) Integration of human herpesvirus 6 in a Burkitt's lymphoma cell line. British Journal of Haematology, 102, 1307–1313.
10.1046/j.1365-2141.1998.00903.x
CAS PubMed Web of Science® Google Scholar
De Bolle, L., Michel, D., Mertens, T., Manichanh, C., Agut, H., De Clercq, E. & Naesens, L. (2002) Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir. Molecular Pharmacology, 62, 714–721.
10.1124/mol.62.3.714
CAS PubMed Web of Science® Google Scholar
Deng, H. & Dewhurst, S. (1989) Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. Journal of Virology, 72, 320–329.
PubMed Web of Science® Google Scholar
Dominguez, G., Dambaugh, T.R., Stamey, F.R., Dewhurst, S., Inoue, N. & Pellett, P.E. (1999) Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. Journal of Virology, 73, 8040–8052.
10.1128/JVI.73.10.8040-8052.1999
CAS PubMed Web of Science® Google Scholar
Drobyski, W.R., Eberle, M., Majewski, D. & Baxter-Lowe, L.A. (1993a) Prevalence of human herpesvirus 6 variant A and B infections in bone marrow transplant recipients as determined by polymerase chain reaction and sequence-specific oligonucleotide probe hybridization. Journal of Clinical Microbiology, 31, 1515–1520.
CAS PubMed Web of Science® Google Scholar
Drobyski, W.R., Dunne, W.M., Burd, E.M., Knox, K.K., Ash, R.C., Horowitz, M.M., Flomenberg, N. & Carrigan, D.R. (1993b) Human herpesvirus 6 (HHV-6) infection allogeneic bone marrow transplant recipients: evidence of a marrow-suppressive role for HHV-6 in vivo. Journal of Infectious Diseases, 167, 735–739.
10.1093/infdis/167.3.735
PubMed Web of Science® Google Scholar
Drobyski, W.R., Knox, K.K., Majewski, D. & Carrigan, D.R. (1994) Brief report: fatal encephalitis due to variant B human herpesvirus 6 infection in a bone marrow-transplant recipient. New England Journal of Medicine, 330, 1356–1360.
10.1056/NEJM199405123301905
CAS PubMed Web of Science® Google Scholar
Frenkel, N., Schirmer, E.C., Wyatt, L.S., Katsafanas, G., Roffman, E., Danovich, R.M. & June, C.H. (1990) Isolation of a new herpesvirus from human CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America, 87, 748–752.
10.1073/pnas.87.2.748
CAS PubMed Web of Science® Google Scholar
Frenkel, N., Katsafanas, G.C., Wyatt, L., Yoshikawa, T. & Asano, Y. (1994) Bone marrow transplant recipients harbor the B variant of human herpesvirus 6. Bone Marrow Transplantation, 14, 839–843.
CAS PubMed Web of Science® Google Scholar
Gautheret-Dejean, A., Manichanh, C., Thien-Ah-Koon, F., Filletm, A.M., Mangeney, N., Vidaud, M., Dhedin, N., Vernant, J.P. & Agut, H. (2002) Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients. Journal of Virological Methods, 100, 27–35.
10.1016/S0166-0934(01)00390-1
CAS PubMed Web of Science® Google Scholar
Gobbi, A., Stoddart, C.A., Malnati, M.S., Locatelli, G., Santoro, F., Abbey, N.W., Bare, C., Linquist-Stepps, V., Moreno, M.B., Herndier, B.G., Lusso, P. & McCune, J.M. (1999) Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. Journal of Experimental Medicine, 189, 1953–1960.
10.1084/jem.189.12.1953
CAS PubMed Web of Science® Google Scholar
Gompels, U.A. & Macaulay, H.A. (1995) Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication. Journal of General Virology, 76, 451–458.
10.1099/0022-1317-76-2-451
CAS PubMed Web of Science® Google Scholar
Goodman, A.D., Mock, D.J., Powers, J.M., Baker, J.V. & Blumberg, B.M. (2003) Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions. Journal of Infectious Diseases, 187, 1365–1376.
10.1086/368172
CAS PubMed Web of Science® Google Scholar
Hall, C.B., Long, C.E., Schnabel, K.C., Caserta, M.T., McIntyre, K.M., Costanzo, M.A., Knott, A., Dewhurst, S., Insel, R.A. & Epstein, L.G. (1994) Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. New England Journal of Medicine, 331, 432–438.
10.1056/NEJM199408183310703
CAS PubMed Web of Science® Google Scholar
Hall, C.B., Caserta, M.T., Schnabel, K.C., Long, C., Epstein, L.G., Insel, R.A. & Dewhurst, S. (1998) Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clinical Infectious Diseases, 26, 132–137.
10.1086/516280
CAS PubMed Web of Science® Google Scholar
Hashimoto, H., Maruyama, H., Fujimoto, K., Sakakura, T., Seishu, S. & Okuda, N. (2002) Hematologic findings associated with thrombocytopenia during the acute phase of exanthem subitum confirmed by primary human herpesvirus-6 infection. Journal of Pediatric Hematology Oncology, 24, 211–214.
10.1097/00043426-200203000-00010
PubMed Web of Science® Google Scholar
He, J., McCarthy, M., Zhou, Y., Chandran, B. & Wood, C. (1996) Infection of primary human fetal astrocytes by human herpesvirus 6. Journal of Virology, 70, 1296–1300.
10.1128/jvi.70.2.1296-1300.1996
CAS PubMed Web of Science® Google Scholar
Huang, L.M., Lee, C.Y., Lin, K.H., Chuu, W.M., Lee, P.I., Chen, R.L., Chen, J.M. & Lin, D.T. (1990) Human herpesvirus-6 associated with fatal haemophagocytic syndrome. Lancet, 336, 60–61.
10.1016/0140-6736(90)91580-4
CAS PubMed Web of Science® Google Scholar
Ihira, M., Yoshikawa, T., Suzuki, K., Ohashi, M., Suga, S., Horibe, K., Tanaka, N., Kimura, H., Kojima, S., Kato, K., Matsuyama, T., Nishiyama, Y. & Asano, Y. (2002) Monitoring of active HHV-6 infection in bone marrow transplant recipients by real time PCR; comparison to detection of viral DNA in plasma by qualitative PCR. Microbiology and Immunology, 46, 701–705.
10.1111/j.1348-0421.2002.tb02754.x
CAS PubMed Web of Science® Google Scholar
Imbert-Marcille, S.C., Tang, X.W., Lepelletier, D., Besse, B., Moreau, P., Billaudel, S. & Milpied, N. (2000) Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: a single-center prospective longitudinal study of 92 patients. Clinical Infectious Diseases, 31, 881–886.
10.1086/318142
CAS PubMed Web of Science® Google Scholar
Isegawa, Y., Mukai, T., Nakano, K., Kagawa, M., Chen, J., Mori, Y., Sunagawa, T., Kawanishi, K., Sashihara, J., Hata, A., Zou, P., Kosuge, H. & Yamanishi, K. (1999) Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. Journal of Virology, 73, 8053–8063.
10.1128/JVI.73.10.8053-8063.1999
CAS PubMed Web of Science® Google Scholar
Ishikawa, K., Hasegawa, K., Naritomi, T., Kanai, N., Ogawa, M., Kato, Y., Kobayashi, M., Torii, N. & Hayashi, N. (2002) Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan. Journal of Gastroenterology, 37, 523–530.
10.1007/s005350200081
CAS PubMed Web of Science® Google Scholar
Isomura, H., Yamada, M., Yoshida, M., Tanaka, H., Kitamura, T., Oda, M., Nii, S. & Seino, Y. (1997) Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells. Journal of Medical Virology, 52, 406–412.
10.1002/(SICI)1096-9071(199708)52:4<406::AID-JMV11>3.0.CO;2-E
CAS PubMed Web of Science® Google Scholar
Johnston, R.E., Geretti, A.M., Prentice, H.G., Clark, A.D., Wheeler, A.C., Potter, M. & Griffiths, P.D. (1999) HHV-6-related secondary graft failure following allogeneic bone marrow transplantation. British Journal of Haematology, 105, 1041–1043.
10.1046/j.1365-2141.1999.01443.x
CAS PubMed Web of Science® Google Scholar
Kadakia, M.P., Rybka, W.B., Stewart, J.A., Patton, J.L., Stamey, F.R., Elsawy, M., Pellett, P.E. & Armstrong, J.A. (1996) Human herpesvirus 6: infection and disease following autologous and allogeneic bone marrow transplantation. Blood, 87, 5341–5354.
10.1182/blood.V87.12.5341.bloodjournal87125341
CAS PubMed Web of Science® Google Scholar
Kakimoto, M., Hasegawa, A., Fujita, S. & Yasukawa, M. (2002) Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection. Journal of Virology, 76, 10338–10345.
10.1128/JVI.76.20.10338-10345.2002
CAS PubMed Web of Science® Google Scholar
Katsafanas, G.C., Schirmer, E.C., Wyatt, L.S. & Frenkel, N. (1996) In vitro activation of human herpesvirus 6 and 7 from latency. Proceedings of the National Academy of Sciences of the United States of America, 93, 9788–9792.
10.1073/pnas.93.18.9788
CAS PubMed Web of Science® Google Scholar
Kawano, Y., Miyazaki, T., Watanabe, T., Suzue, A., Kan-nuki, S., Kagechi, T., Onishi, T., Kaneko, M., Kanamaru, S., Wakata, Y., Nakagawa, R., Suenaga, K., Suzuya, H., Abe, T., Nagahiro, S., Kuroda, Y. & Takaue, Y. (2000) HLA-mismatched CD34-selected stem cell transplant complicated by HHV-6 reactivation in the central nervous system. Bone Marrow Transplantation, 25, 787–790.
10.1038/sj.bmt.1702220
CAS PubMed Web of Science® Google Scholar
Kempf, W., Adams, V., Wey, N., Moos, R., Schmid, M., Avitabile, E. & Campadelli-Fiume, G. (1997) CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Proceedings of the National Academy of Sciences of the United States of America, 94, 7600–7605.
10.1073/pnas.94.14.7600
CAS PubMed Web of Science® Google Scholar
Knox, K.K. & Carrigan, D.R. (1992) In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection. Journal of Infectious Diseases, 165, 925–929.
10.1093/infdis/165.5.925
PubMed Web of Science® Google Scholar
Kondo, K., Kondo, T., Okuno, T., Takahashi, M. & Yamanishi, K. (1991) Latent human herpesvirus 6 infection of human monocytes/macrophages. Journal of General Virology, 72, 1401–1408.
10.1099/0022-1317-72-6-1401
CAS PubMed Web of Science® Google Scholar
Kondo, K., Nagafuji, H., Hata, A., Tomomori, C. & Yamanishi, K. (1993) Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. Journal of Infectious Diseases, 167, 1197–1200.
10.1093/infdis/167.5.1197
PubMed Web of Science® Google Scholar
Kondo, K., Shimada, K., Sashihara, J., Tanaka-Taya, K. & Yamanishi, K. (2002) Identification of human herpesvirus 6 latency-associated transcripts. Journal of Virology, 76, 4145–4151.
10.1128/JVI.76.8.4145-4151.2002
CAS PubMed Web of Science® Google Scholar
Kondo, K., Sashihara, J., Shimada, K., Takemoto, M., Amo, K., Miyagawa, H. & Yamanishi, K. (2003) Recognition of a novel stage of beta herpesvirus latency in human herpesvirus 6. Journal of Virology, 77, 2258–2264.
10.1128/JVI.77.3.2258-2264.2003
CAS PubMed Web of Science® Google Scholar
Lautenschlager, I., Linnavuori, K. & Hockerstedt, K. (2000) Human herpesvirus-6 antigenemia after liver transplantation. Transplantation, 69, 2561–2566.
10.1097/00007890-200006270-00015
CAS PubMed Web of Science® Google Scholar
Le Cleach, L., Joberty, C., Fillet, A.M., Sutton, L., Cordonnier, C., Frances, C., Agut, H. & Chosidow, O. (1998) Human herpesvirus 6 infection in patients with exanthema after allogeneic bone marrow transplantation. Archives of Dermatology, 134, 759–760.
10.1001/archderm.134.6.759
CAS PubMed Web of Science® Google Scholar
Lindquester, G.J. & Pellett, P.E. (1991) Properties of the human herpesvirus 6 strain Z29 genome: G + C content, length, and presence of variable-length directly repeated terminal sequence elements. Virology, 182, 102–110.
10.1016/0042-6822(91)90653-S
CAS PubMed Web of Science® Google Scholar
Ljungman, P., Wang, F.Z., Clark, D.A., Emery, V.C., Remberger, M., Ringden, O. & Linde, A. (2000) High levels of human herpesvirus 6 DNA in peripheral blood leukocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients. British Journal of Haematology, 111, 774–781.
10.1111/j.1365-2141.2000.02422.x
CAS PubMed Web of Science® Google Scholar
Locatelli, G., Santoro, F., Veglia, F., Gobbi, A., Lusso, P. & Malnati, M.S. (2000) Real-time quantitative PCR for human herpesvirus 6 DNA. Journal of Clinical Microbiology, 38, 4042–4048.
CAS PubMed Web of Science® Google Scholar
Luppi, M., Marasca, R., Barozzi, P., Ferrari, S., Ceccherini-Nelli, L., Batoni, G., Merelli, E. & Torelli, G. (1993) Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. Journal of Medical Virology, 40, 44–52.
10.1002/jmv.1890400110
CAS PubMed Web of Science® Google Scholar
Luppi, M., Barozzi, P., Maiorana, A., Marasca, R., Trovato, R., Fano, R., Ceccherini-Nelli, L. & Torelli, G. (1995) Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. Journal of Medical Virology, 47, 105–111.
10.1002/jmv.1890470119
CAS PubMed Web of Science® Google Scholar
Luppi, M., Barozzi, P., Morris, C., Maiorana, A., Garber, R., Bonacorsi, G., Donelli, A., Marasca, R., Tabilio, A. & Torelli, G. (1999) Human herpesvirus 6 latently infects early bone marrow progenitors in vivo. Journal of Virology, 73, 754–759.
10.1128/JVI.73.1.754-759.1999
CAS PubMed Web of Science® Google Scholar
Lusso, P., Markham, P.D., Tschachler, E., Di Marzo Veronese, F., Salahuddin, S.Z., Ablashi, D.V., Pahwa, S., Krohn, K. & Gallo, R.C. (1988) In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). Journal of Experimental Medicine, 167, 1659–1670.
10.1084/jem.167.5.1659
CAS PubMed Web of Science® Google Scholar
Lusso, P., De Maria, A., Malnati, M., Lori, F., DeRocco, S.E., Baseler, M. & Gallo, R.C. (1991) Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6. Nature, 349, 533–535.
10.1038/349533a0
CAS PubMed Web of Science® Google Scholar
Lusso, P., Malnati, M.S., Garzino-Demo, A., Crowley, R.W., Long, E.O. & Gallo, R.C. (1993) Infection of natural killer cells by human herpesvirus 6. Nature, 362, 458–462.
10.1038/362458a0
CAS PubMed Web of Science® Google Scholar
Lusso, P., Garzino-Demo, A., Crowley, R.W. & Malnati, M.S. (1995) Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. Journal of Experimental Medicine, 181, 1303–1310.
10.1084/jem.181.4.1303
CAS PubMed Web of Science® Google Scholar
MacLean, H.J. & Douen, A.G. (2002) Severe amnesia associated with human herpesvirus 6 encephalitis after bone marrow transplantation. Transplantation, 73, 1086–1089.
10.1097/00007890-200204150-00012
PubMed Web of Science® Google Scholar
Maeda, Y., Teshima, T., Yamada, M., Shinagawa, K., Nakao, S., Ohno, Y., Kojima, K., Hara, M., Nagafuji, K., Hayashi, S., Fukuda, S., Sawada, H., Matsue, K., Takenaka, K., Ishimaru, F., Ikeda, K., Niiya, K. & Harada, M. (1999) Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation. British Journal of Haematology, 105, 295–302.
10.1111/j.1365-2141.1999.01290.x
CAS PubMed Web of Science® Google Scholar
Manichanh, C., Olivier-Aubron, C., Lagarde, J.P., Aubin, J.T., Bossi, P., Gautheret-Dejean, A., Huraux, J.M. & Agut, H. (2001) Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo. Journal of General Virology, 82, 2767–2776.
10.1099/0022-1317-82-11-2767
CAS PubMed Web of Science® Google Scholar
Matsuda, Y., Hara, J., Miyoshi, H., Osugi, Y., Fujisaki, H., Takai, K., Ohta, H., Tanaka-Taya, K., Yamanishi, K. & Okada, S. (1999) Thrombotic microangiopathy associated with reactivation of human herpesvirus-6 following high dose chemotherapy with autologous bone marrow transplantation in young children. Bone Marrow Transplantation, 24, 919–923.
10.1038/sj.bmt.1702003
CAS PubMed Web of Science® Google Scholar
Montejo, M., Ramon Fernandez, J., Testillano, M., Valdivieso, A., Aguirrebengoa, K., Varas, C., Olaizola, A. & De Urbina, J.O. (2002) Encephalitis caused by human herpesvirus-6 in a liver transplant recipient. European Neurology, 48, 234–235.
10.1159/000066172
PubMed Web of Science® Google Scholar
Mookerjee, B.P. & Vogelsang, G. (1997) Human herpes virus-6 encephalitis after bone marrow transplantation: successful treatment with ganciclovir. Bone Marrow Transplantation, 20, 905–906.
10.1038/sj.bmt.1700988
CAS PubMed Web of Science® Google Scholar
Mori, Y., Akkapaiboon, P., Yang, X. & Yamanishi, K. (2003a) The human herpesvirus 6 U100 gene product is the third component of the gH–gL glycoprotein complex on the viral envelope. Journal of Virology, 77, 2452–2458.
10.1128/JVI.77.4.2452-2458.2003
CAS PubMed Web of Science® Google Scholar
Mori, Y., Yang, X., Akkapaiboon, P., Okuno, T. & Yamanishi, K. (2003b) Human herpesvirus 6 variant A glycoprotein H–glycoprotein L–glycoprotein Q complex associates with human CD46. Journal of Virology, 77, 4992–4999.
10.1128/JVI.77.8.4992-4999.2003
CAS PubMed Web of Science® Google Scholar
Nicholas, J. (1996) Determination and analysis of the complete nucleotide sequence of human herpesvirus. Journal of Virology, 70, 5975–5989.
CAS PubMed Web of Science® Google Scholar
Norton, R.A., Caserta, M.T., Hall, C.B., Schnabel, K., Hocknell, P. & Dewhurst, S. (1999) Detection of human herpesvirus 6 by reverse transcription-PCR. Journal of Clinical Microbiology, 37, 3672–3675.
CAS PubMed Web of Science® Google Scholar
Pruksananonda, P., Hall, C.B., Insel, R.A., McIntyre, K., Pellett, P.E., Long, C.E., Schnabel, K.C., Pincus, P.H., Stamey, F.R. & Dambaugh, T.R. (1992) Primary human herpesvirus 6 infection in young children. New England Journal of Medicine, 326, 1445–1450.
10.1056/NEJM199205283262201
PubMed Web of Science® Google Scholar
Rapaport, D., Engelhard, D., Tagger, G., Or, R. & Frenkel, N. (2002) Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipients. Transplant Infectious Disease, 4, 10–16.
10.1034/j.1399-3062.2002.040101.x
CAS PubMed Google Scholar
Rapp, J.C., Krug, L.T., Inoue, N., Dambaugh, T.R. & Pellett, P.E. (2000) U94, the human herpesvirus 6 homolog of the parvovirus nonstructural gene, is highly conserved among isolates and is expressed at low mRNA levels as a spliced transcript. Virology, 268, 504–516.
10.1006/viro.1999.0163
CAS PubMed Web of Science® Google Scholar
Rieux, C., Gautheret-Dejean, A., Challine-Lehmann, D., Kirch, C., Agut, H. & Vernant, J.P. (1998) Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation. Transplantation, 65, 1408–1411.
10.1097/00007890-199805270-00024
CAS PubMed Web of Science® Google Scholar
Robert, C., Aubin, J.T., Visse, B., Fillet, A.M., Huraux, J.M. & Agut, H. (1996) Difference in permissiveness of human fibroblast cells to variants A and B of human herpesvirus-6. Research in Virology, 147, 219–225.
10.1016/0923-2516(96)89652-X
CAS PubMed Web of Science® Google Scholar
Rosenfeld, C.S., Rybka, W.B., Weinbaum, D., Carrigan, D.R., Knox, K.K., Andrews, D.F. & Shadduck, R.K. (1995) Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6. Experimental Hematology, 23, 626–629.
PubMed Web of Science® Google Scholar
Rossi, C., Delforge, M.L., Jacobs, F., Wissing, M., Pradier, O., Remmelink, M., Byl, B., Thys, J.P. & Liesnard, C. (2001) Fatal primary infection due to human herpesvirus 6 variant A in a renal transplant recipient. Transplantation, 71, 288–292.
10.1097/00007890-200101270-00021
CAS PubMed Web of Science® Google Scholar
Rotola, A., Ravaioli, T., Gonelli, A., Dewhurst, S., Cassai, E. & Di Luca, D. (1998) U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Proceedings of the National Academy of Sciences of the United States of America, 95, 13911–13916.
10.1073/pnas.95.23.13911
CAS PubMed Web of Science® Google Scholar
Salahuddin, S.Z., Ablashi, D.V., Markham, P.D., Josephs, S.F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B. & Gallo, R.C. (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science, 234, 596–601.
10.1126/science.2876520
CAS PubMed Web of Science® Google Scholar
Santoro, F., Kennedy, P.E., Locatelli, G., Malnati, M.S., Berger, E.A. & Lusso, P. (1999) CD46 is a cellular receptor for human herpesvirus 6. Cell, 99, 817–827.
10.1016/S0092-8674(00)81678-5
CAS PubMed Web of Science® Google Scholar
Santoro, F., Greenstone, H.L., Insinga, A., Liszewski, M.K., Atkinson, J.P., Lusso, P. & Berger, E.A. (2003) Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46. Journal of Biological Chemistry, 278, 25964–25969.
10.1074/jbc.M302373200
CAS PubMed Web of Science® Google Scholar
Sashihara, J., Tanaka-Taya, K., Tanaka, S., Amo, K., Miyagawa, H., Hosoi, G., Taniguchi, T., Fukui, T., Kasuga, N., Aono, T., Sako, M., Hara, J., Yamanishi, K. & Okada, S. (2002) High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood, 100, 2005–2011.
10.1182/blood.V100.6.2005
CAS PubMed Web of Science® Google Scholar
Schirmer, E.C., Wyatt, L.S., Yamanishi, K., Rodriguez, W.J. & Frenkel, N. (1991) Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proceedings of the National Academy of Sciences of the United States of America, 88, 5922–5926.
10.1073/pnas.88.13.5922
CAS PubMed Web of Science® Google Scholar
Secchiero, P., Carrigan, D.R., Asano, Y., Benedetti, L., Crowley, R.W., Komaroff, A.L., Gallo, R.C. & Lusso, P. (1995) Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. Journal of Infectious Diseases, 171, 273–280.
10.1093/infdis/171.2.273
CAS PubMed Web of Science® Google Scholar
Singh, N. & Paterson, D.L. (2000) Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus. Transplantation, 69, 2474–2479.
10.1097/00007890-200006270-00002
CAS PubMed Web of Science® Google Scholar
Singh, N., Carrigan, D.R., Gayowski, T., Singh, J. & Marino, I.R. (1995) Variant B human herpesvirus-6 associated febrile dermatosis with thrombocytopenia and encephalopathy in a liver transplant recipient. Transplantation, 60, 1355–1357.
CAS PubMed Web of Science® Google Scholar
Singh, N., Carrigan, D.R., Gayowski, T. & Marino, I.R. (1997) Human herpesvirus-6 infection in liver transplant recipients. Documentation of pathogenicity. Transplantation, 64, 674–678.
10.1097/00007890-199709150-00002
CAS PubMed Web of Science® Google Scholar
Suga, S., Yoshikawa, T., Asano, Y., Kozawa, T., Nakashima, T., Kobayashi, I., Yazaki, T., Yamamoto, H., Kajita, Y. & Ozaki, T. (1993) Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. Annals of Neurology, 33, 597–603.
10.1002/ana.410330607
PubMed Web of Science® Google Scholar
Suzuki, Y., Inagi, R., Aono, T., Yamanishi, K. & Shiohara, T. (1998) Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Archives of Dermatology, 134, 1108–1112.
10.1001/archderm.134.9.1108
CAS PubMed Web of Science® Google Scholar
Tajiri, H., Tanaka-Taya, K., Ozaki, Y., Okada, S., Mushiake, S. & Yamanishi, K. (1997) Chronic hepatitis in an infant, in association with human herpesvirus-6 infection. Journal of Pediatrics, 131, 473–475.
10.1016/S0022-3476(97)80082-0
CAS PubMed Web of Science® Google Scholar
Takahashi, K., Sonoda, S., Higashi, K., Kondo, T., Takahashi, H., Takahashi, M. & Yamanishi, K. (1989) Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. Journal of Virology, 63, 3161–3163.
CAS PubMed Web of Science® Google Scholar
Tanaka, N., Kimura, H., Hoshino, Y., Kato, K., Yoshikawa, T., Asano, Y., Horibe, K., Kojima, S. & Morishima, T. (2000) Monitoring for herpesviruses in unrelated cord blood transplantation. Bone Marrow Transplantation, 26, 1193–1197.
10.1038/sj.bmt.1702710
CAS PubMed Web of Science® Google Scholar
Tanaka-Taya, K., Kondo, T., Torigoe, S., Okada, S., Mukai, T. & Yamanishi, K. (1994) Human herpesvirus 7: another causal agent for roseola (exanthem subitum). Journal of Pediatrics, 125, 1–5.
10.1016/S0022-3476(94)70113-X
PubMed Web of Science® Google Scholar
Tanaka-Taya, K., Kondo, T., Nakagawa, N., Inagi, R., Miyoshi, H., Sunagawa, T., Okada, S. & Yamanishi, K. (2000) Reactivation of human herpesvirus 6 by infection of human herpesvirus 7. Journal of Medical Virology, 60, 284–289.
10.1002/(SICI)1096-9071(200003)60:3<284::AID-JMV6>3.0.CO;2-8
CAS PubMed Web of Science® Google Scholar
Tohyama, M., Yahata, Y., Yasukawa, M., Inagi, R., Urano, Y., Yamanishi, K. & Hashimoto, K. (1998) Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6. Archives of Dermatology, 134, 1113–1117.
10.1001/archderm.134.9.1113
CAS PubMed Web of Science® Google Scholar
Tokimasa, S., Hara, J., Osugi, Y., Ohta, H., Matsuda, Y., Fujisaki, H., Sawada, A., Kim, J.Y., Sashihara, J., Amou, K., Miyagawa, H., Tanaka-Taya, K., Yamanishi, K. & Okada, S. (2002) Ganciclovir is effective for prophylaxis and treatment of human herpesvirus-6 in allogeneic stem cell transplantation. Bone Marrow Transplantation, 29, 595–598.
10.1038/sj.bmt.1703423
CAS PubMed Web of Science® Google Scholar
Van den Bosch, G., Locatelli, G., Geerts, L., Faga, G., Ieven, M., Goossens, H., Bottiger, D., Oberg, B., Lusso, P. & Berneman, Z.N. (2001) Development of reverse transcriptase PCR assays for detection of active human herpesvirus 6 infection. Journal of Clinical Microbiology, 39, 2308–2310.
10.1128/JCM.39.6.2308-2310.2001
CAS PubMed Web of Science® Google Scholar
Wainwright, M.S., Martin, P.L., Morse, R.P., Lacaze, M., Provenzale, J.M., Coleman, R.E., Morgan, M.A., Hulette, C., Kurtzberg, J., Bushnell, C., Epstein, L. & Lewis, D.V. (2001) Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Annals of Neurology, 50, 612–619.
10.1002/ana.1251
CAS PubMed Web of Science® Google Scholar
Wang, F.Z., Dahl, H., Linde, A., Brytting, M., Ehrnst, A. & Ljungman, P. (1996) Lymphotropic herpesviruses in allogeneic bone marrow transplantation. Blood, 88, 3615–3620.
10.1182/blood.V88.9.3615.bloodjournal8893615
CAS PubMed Web of Science® Google Scholar
Wang, F.Z., Linde, A., Hagglund, H., Testa, M., Locasciulli, A. & Ljungman, P. (1999) Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? Clinical Infectious Diseases, 28, 562–568.
10.1086/515142
CAS PubMed Web of Science® Google Scholar
Watanabe, T., Kawamura, T., Jacob, S.E., Aquilino, E.A., Orenstein, J.M., Black, J.B. & Blauvelt, A. (2002) Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. Journal of Investigative Dermatology, 119, 793–797.
10.1046/j.1523-1747.2002.00200.x
CAS PubMed Web of Science® Google Scholar
Wilborn, F., Brinkmann, V., Schmidt, C.A., Neipel, F., Gelderblom, H. & Siegert, W. (1994) Herpesvirus type 6 in patients undergoing bone marrow transplantation: serologic features and detection by polymerase chain reaction. Blood, 83, 3052–3058.
CAS PubMed Web of Science® Google Scholar
Wyatt, L.S., Rodriguez, W.J., Balachandran, N. & Frenkel, N. (1991) Human herpesvirus 7: antigenic properties and prevalence in children and adults. Journal of Virology, 65, 6260–6265.
CAS PubMed Web of Science® Google Scholar
Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y. & Kurata, T. (1988) Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet, 1, 1065–1067.
10.1016/S0140-6736(88)91893-4
CAS PubMed Web of Science® Google Scholar
Yoshida, M., Yamada, M., Tsukazaki, T., Chatterjee, S., Lakeman, F.D., Nii, S. & Whitley, R.J. (1998) Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral Research, 40, 73–84.
10.1016/S0166-3542(98)00049-7
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Suga, S., Asano, Y., Yazaki, T., Kodama, H. & Ozaki, T. (1989) Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. Pediatrics, 84, 675–677.
10.1542/peds.84.4.675
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Sobue, R., Hirano, M., Fukuda, M., Kojima, S. & Matsuyama, T. (1991) Human herpesvirus-6 infection in bone marrow transplantation. Blood, 78, 1381–1384.
10.1182/blood.V78.5.1381.1381
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Nakashima, T., Suga, S., Asano, Y., Yazaki, T., Kimura, H., Morishima, T., Kondo, K. & Yamanishi, K. (1992a) Human herpesvirus-6 DNA in cerebrospinal fluid of child with exanthem subitum and meningoencephalitis. Pediatrics, 89, 888–890.
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Ono, Y., Fujita, T., Tsuzuki, K., Sugiyama, S. & Oshima, S. (1992b) Prospective study of human herpesvirus-6 infection in renal transplantation. Transplantation, 54, 879–883.
10.1097/00007890-199211000-00022
PubMed Web of Science® Google Scholar
Yoshikawa, T., Nakashima, T., Asano, Y., Suga, S., Yazaki, T., Kojima, S., Mukai, T. & Yamanishi, K. (1992c) Endonuclease analyses of DNA of human herpesvirus-6 isolated from blood before and after bone marrow transplantation. Journal of Medical Virology, 37, 228–231.
10.1002/jmv.1890370314
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Asano, Y., Kobayashi, I., Nakashima, T. & Yazaki, T. (1993a) Exacerbation of idiopathic thrombocytopenic purpura by primary human herpesvirus 6 infection. Pediatric Infectious Disease Journal, 12, 409–410.
10.1097/00006454-199305000-00014
PubMed Web of Science® Google Scholar
Yoshikawa, T., Kobayashi, I., Asano, Y., Nakashima, T., Yazaki, T., Kojima, S. & Yamada, A. (1993b) Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia. American Journal of Pediatric Hematology Oncology, 15, 424–426.
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Suzuki, K., Ihira, M., Furukawa, H., Suga, S., Asano, Y., Kojima, S., Kato, K. & Matsuyama, T. (1998) Prediction of human herpesvirus 6 infection after allogeneic bone marrow transplantation. Blood, 92, 2597–2599.
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Ihira, M., Suzuki, K., Suga, S., Iida, K., Saito, Y., Asonuma, K., Tanaka, K. & Asano, Y. (2000) Human herpesvirus 6 infection after living related liver transplantation. Journal of Medical Virology, 62, 52–59.
10.1002/1096-9071(200009)62:1<52::AID-JMV9>3.0.CO;2-5
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Ihira, M., Suzuki, K., Suga, S., Kito, H., Iwasaki, T., Kurata, T., Tanaka, T., Saito, Y. & Asano, Y. (2001a) Fatal acute myocarditis in an infant with human herpesvirus 6 infection. Journal of Clinical Pathology, 54, 792–795.
10.1136/jcp.54.10.792
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Ihira, M., Suzuki, K., Suga, S., Asano, Y., Asonuma, K., Tanaka, K. & Nishiyama, Y. (2001b) Primary human herpesvirus 6 infection in liver transplant recipients. Journal of Pediatrics, 138, 921–925.
10.1067/mpd.2001.113622
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Black, J.B., Ihira, M., Suzuki, K., Suga, S., Iida, K., Saito, Y., Asonuma, K., Tanaka, K. & Asano, Y. (2001c) Comparison of specific serological assays for diagnosing human herpesvirus 6 infection after liver transplantation. Clinical Diagnostic Laboratory Immunology, 8, 170–173.
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Ihira, M., Ohashi, M., Suga, S., Asano, Y., Miyazaki, H., Hirano, M., Suzuki, K., Matsunaga, K., Horibe, K., Kojima, S., Kudo, K., Kato, K., Matsuyama, T. & Nishiyama, Y. (2001d) Correlation between HHV-6 infection and skin rash after allogeneic bone marrow transplantation. Bone Marrow Transplantation, 28, 77–81.
10.1038/sj.bmt.1703099
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Asano, Y., Akimoto, S., Ozaki, T., Iwasaki, T., Kurata, T., Goshima, F. & Nishiyama, Y. (2002a) Latent infection of human herpesvirus 6 in astrocytoma cell line and alteration of cytokine synthesis. Journal of Medical Virology, 66, 497–505.
10.1002/jmv.2172
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Asano, Y., Ihira, M., Suzuki, K., Ohashi, M., Suga, S., Kudo, K., Horibe, K., Kojima, S., Kato, K., Matsuyama, T. & Nishiyama, Y. (2002b) Human herpesvirus 6 viremia in bone marrow transplant recipients: clinical features and risk factors. Journal of Infectious Diseases, 185, 847–853.
10.1086/339411
PubMed Web of Science® Google Scholar
Yoshikawa, T., Goshima, F., Akimoto, S., Ozaki, T., Iwasaki, T., Kurata, T., Asano, Y. & Nishiyama, Y. (2003a) Human herpesvirus 6 infection of human epidermal cell line: pathogenesis of skin manifestations. Journal of Medical Virology, 71, 62–68.
10.1002/jmv.10461
CAS PubMed Web of Science® Google Scholar
Yoshikawa, T., Akimoto, S., Nishimura, N., Ozaki, T., Ihira, M., Ohashi, M., Morooka, M., Suga, S., Asano, Y., Takemoto, M. & Nishiyama, Y. (2003b) Evaluation of active human herpesvirus 6 infection by reverse transcription-PCR. Journal of Medical Virology, 70, 267–272.
10.1002/jmv.10388
CAS PubMed Web of Science® Google Scholar
Zerr, D.M., Gooley, T.A., Yeung, L., Huang, M.L., Carpenter, P., Wade, J.C., Corey, L. & Anasetti, C. (2001) Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients. Clinical Infectious Diseases, 33, 763–771.
10.1086/322642
CAS PubMed Web of Science® Google Scholar
Zerr, D.M., Gupta, D., Huang, M.L., Carter, R. & Corey, L. (2002) Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clinical Infectious Diseases, 34, 309–317.
10.1086/338044
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume124, Issue4

February 2004

Pages 421-432

Human herpesvirus 6 infection in hematopoietic stem cell transplant patients

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Human herpesvirus 6 infection in hematopoietic stem cell transplant patients

References

Citing Literature

References

Related

Information