Affinity of Antigen–Antibody Interactions - Goldblatt - Major Reference Works - Wiley Online Library

Zhejiang Agr & For University

Zhejiang Agr & For University

Search term
Advanced Search Citation Search
Search term
Advanced Search Citation Search

Affinity of Antigen–Antibody Interactions

David Goldblatt,

David Goldblatt

Institute of Child Health, University College London, UK

Search for more papers by this author

David Goldblatt,

David Goldblatt

Institute of Child Health, University College London, UK

Search for more papers by this author

First published: 25 April 2001

https://doi.org/10.1038/npg.els.0001113

Citations: 1

Read the full text

Share a link

Email
Wechat
Bluesky

Abstract

Antibody affinity is the strength with which antibody binds to its target antigen. It is influenced by a variety of factors including valency and the precise fit of the antigen in the antigen binding groove. Antibody affinity increases over time following contact or repeated immunization with certain types of antigen. The affinity of an antibody may have an influence on its function.

Further Reading

Berek C (1993) Somatic mutation and memory. Current Opinion in Immunology 5: 218–222.
10.1016/0952-7915(93)90007-F
CAS PubMed Web of Science® Google Scholar
Goldberg ME and Djavadi-Ohaniance L (1993) Methods for the measurement of antibody/antigen affinity based on ELISA and RIA. Current Opinion in Immunology 5: 278–281.
10.1016/0952-7915(93)90018-N
CAS PubMed Web of Science® Google Scholar
Goldblatt D, Pinto Vaz ARJPM and Miller E (1998) Antibody avidity as a surrogate marker of successful priming by Haemophilus influenzae type b conjugate vaccines following infant immunization. Journal of Infectious Diseases 177: 1112–1115.
10.1086/517407
CAS PubMed Web of Science® Google Scholar
Goldblatt D (1997) Simple solid phase assays of avidity. In: MW Turner and AP Johnstone (eds) Immunochemistry 2: A Practical Approach, pp. 31–51. Oxford: IRL Oxford University Press.
10.1093/oso/9780199636105.003.0002
Google Scholar
McHeyzer-Williams MG and Ahmed R (1999) B cell memory and the long lived plasma cell. Current Opinion in Immunology 11: 172–179.
10.1016/S0952-7915(99)80029-6
CAS PubMed Web of Science® Google Scholar
Nossal GJV (1992) The molecular and cellular basis of affinity maturation. Cell 68: 1–2.
10.1016/0092-8674(92)90198-L
CAS PubMed Web of Science® Google Scholar
Rada C, Gupta AK, Ghereardi and Milstein C (1991) Mutation and selection during the secondary response to 2-phenyloxazolone. Proceedings of the National Academy of Sciences of the USA 88: 5508–5512.
10.1073/pnas.88.13.5508
CAS PubMed Web of Science® Google Scholar
Rajewsky K (1996) Clonal selection and learning in the antibody system. Nature 381: 751–758.
10.1038/381751a0
CAS PubMed Web of Science® Google Scholar
Tarlinton DM and Smith KG (2000) Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre. Immunology Today 21: 436–441.
10.1016/S0167-5699(00)01687-X
CAS PubMed Web of Science® Google Scholar

Citing Literature

Browse other articles of this reference work:

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.