N-methyl-d-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain
Corresponding Author
Valérie Kayser
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France. Tel.: +33 1 4077 9709; fax: +33 1 4077 9790 [email protected].Search for more papers by this authorAlban Latrémolière
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorMichel Hamon
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorSylvie Bourgoin
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorCorresponding Author
Valérie Kayser
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France. Tel.: +33 1 4077 9709; fax: +33 1 4077 9790 [email protected].Search for more papers by this authorAlban Latrémolière
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorMichel Hamon
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorSylvie Bourgoin
INSERM U894, Neuropsychopharmacology, Centre de Psychiatrie et Neurosciences, 91, Boulevard de l'Hôpital, Paris F-75013, France
Université Pierre et Marie Curie—Paris 6, Faculté de médecine Pierre et Marie Curie, Site Pitié-Salpêtrière, UMR S894, 91, Boulevard de l'Hôpital, Paris F-75013, France
Search for more papers by this authorAbstract
Previous studies showed that triptans and other 5-HT1B/1D-receptor agonists attenuate hyper-responsiveness to mechanical stimulation of the face in a rat model of trigeminal neuropathic pain, probably by activating 5-HT1B/1D-receptors on primary afferent nociceptive fibers. We now tested whether blockade of post-synaptic receptors for the excitatory amino acid glutamate released by these fibers would increase this action. We thus evaluated whether (±)1-hydroxy-3-aminopyrrolidine-2-one (HA-966), an antagonist at the glycine/d-serine site of N-methyl-d-aspartate (NMDA)-receptors, would potentiate the anti-allodynic action of dihydroergotamine and zolmitriptan in rats with chronic constriction injury to the infraorbital nerve (CCI-ION). Complementary studies were performed with other NMDA-receptor ligands and in rats with chronic constriction injury to the sciatic nerve (CCI-SN) for comparison.
Injury was produced by loose ligatures of the nerves. Responsiveness to mechanical stimulation (vibrissae or hindpaw territories) with von Frey filaments was used to evaluate allodynia 2 weeks after nerve ligature. Rats received NMDA-receptor ligands or saline 20 min before dihydroergotamine (25–100μg/kg, i.v.) or zolmitriptan (25–100μg/kg, s.c.).
HA-966 (2.5 mg/kg, s.c.), inactive on its own, enhanced the anti-allodynic effects of dihydroergotamine (eightfold increase) and zolmitriptan (threefold increase) in CCI-ION rats, but these drugs exerted no effects in allodynic CCI-SN rats. NMDA-receptor blockade by memantine (5 mg/kg, i.p.) also enhanced, whereas activation at glycine/NMDA site by d-cycloserine (3 mg/kg, i.p.) reduced the anti-allodynic properties of zolmitriptan in CCI-ION rats. Combined administration of NMDA-receptor antagonist and 5-HT1B/1D-receptor agonist may be a promising approach for alleviating trigeminal neuropathic pain.
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