Article
A Nodal Positivity Constant: New Perspectives in Lymph Node Evaluation and Colorectal Cancer
Niamh M. Hogan,
Desmond C. Winter,
Niamh M. Hogan
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
Search for more papers by this authorCorresponding Author
Desmond C. Winter
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
[email protected]Search for more papers by this authorNiamh M. Hogan,
Desmond C. Winter,
Niamh M. Hogan
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
Search for more papers by this authorCorresponding Author
Desmond C. Winter
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
[email protected]Search for more papers by this authorAbstract
Purpose
To date, associations between the number of lymph nodes evaluated, staging, and survival have been examined in the context of large population-based studies conducted by a small number of investigators. Therefore, although high-quality data are available, perspective is lacking.
Methods
Studies for this paper were identified by searches of Medline, Scopus, PubMed, and manual searching of references from articles, using the search terms ‘‘colorectal cancer’’, ‘‘nodal status’’ and ‘‘lymph node’’.
Results
It is clear that survival benefit increases with the increasing number of lymph nodes harvested. Despite this observation, there has been no significant increase in the proportion of node-positive cancers over the past two decades.
Conclusion
The nodal positivity rate for colorectal cancer consistently approximates 40 % across a wide range of studies internationally, a phenomenon that has not previously been recognized in the literature. We review the evidence and introduce the concept of a nodal positivity constant.
References
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