REVIEW
Metal-based nanoparticles for bone tissue engineering
Reza Eivazzadeh-Keihan,
Ehsan Bahojb Noruzi,
Karim Khanmohammadi Chenab,
Amir Jafari,
Fateme Radinekiyan,
Seyed Masoud Hashemi,
Farnoush Ahmadpour,
Ali Behboudi,
Jafar Mosafer,
Ahad Mokhtarzadeh,
Ali Maleki,
Michael R. Hamblin,
Reza Eivazzadeh-Keihan
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorEhsan Bahojb Noruzi
Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Search for more papers by this authorKarim Khanmohammadi Chenab
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorAmir Jafari
Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFateme Radinekiyan
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorSeyed Masoud Hashemi
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorFarnoush Ahmadpour
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorAli Behboudi
Faculty of Chemical, Petroleum and Gas Engineering, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorJafar Mosafer
Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Search for more papers by this authorCorresponding Author
Ahad Mokhtarzadeh
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biotechnology, Higher Education Institute of Rab-Rashid, Tabriz, Iran
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Ali Maleki
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Michael R. Hamblin
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorReza Eivazzadeh-Keihan,
Ehsan Bahojb Noruzi,
Karim Khanmohammadi Chenab,
Amir Jafari,
Fateme Radinekiyan,
Seyed Masoud Hashemi,
Farnoush Ahmadpour,
Ali Behboudi,
Jafar Mosafer,
Ahad Mokhtarzadeh,
Ali Maleki,
Michael R. Hamblin,
Reza Eivazzadeh-Keihan
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorEhsan Bahojb Noruzi
Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Search for more papers by this authorKarim Khanmohammadi Chenab
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorAmir Jafari
Department of Medical Nanotechnology, Faculty of Advanced Technology in Medicine, Iran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorFateme Radinekiyan
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorSeyed Masoud Hashemi
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorFarnoush Ahmadpour
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorAli Behboudi
Faculty of Chemical, Petroleum and Gas Engineering, Iran University of Science and Technology, Tehran, Iran
Search for more papers by this authorJafar Mosafer
Research Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Search for more papers by this authorCorresponding Author
Ahad Mokhtarzadeh
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biotechnology, Higher Education Institute of Rab-Rashid, Tabriz, Iran
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Ali Maleki
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Michael R. Hamblin
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA
Correspondence
Ahad Mokhtarzadeh, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Email: [email protected]
Ali Maleki, Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Email: [email protected]
Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal-based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle-based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.
CONFLICT OF INTEREST
MRH declares the following potential conflicts of interest. Scientific Advisory Boards: Transdermal Cap Inc, Cleveland, OH; BeWell Global Inc, Wan Chai, Hong Kong; Hologenix Inc. Santa Monica, CA; LumiThera Inc, Poulsbo, WA; Vielight, Toronto, Canada; Bright Photomedicine, Sao Paulo, Brazil; Quantum Dynamics LLC, Cambridge, MA; Global Photon Inc, Bee Cave, TX; Medical Coherence, Boston MA; NeuroThera, Newark DE; JOOVV Inc, Minneapolis-St. Paul MN; AIRx Medical, Pleasanton CA; FIR Industries, Inc. Ramsey, NJ; UVLRx Therapeutics, Oldsmar, FL; Ultralux UV Inc, Lansing MI; Illumiheal & Petthera, Shoreline, WA; MB Lasertherapy, Houston, TX; ARRC LED, San Clemente, CA; Varuna Biomedical Corp. Incline Village, NV; Niraxx Light Therapeutics, Inc, Boston, MA. Consulting; Lexington Int, Boca Raton, FL; USHIO Corp, Japan; Merck KGaA, Darmstadt, Germany; Philips Electronics Nederland B.V. Eindhoven, Netherlands; Johnson & Johnson Inc, Philadelphia, PA; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany. Stockholdings: Global Photon Inc, Bee Cave, TX; Mitonix, Newark, DE.
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