Amorphous RuO2 Nanozymes with an Excellent Catalytic Efficiency Superior to Natural Peroxidases
Zirui Qin
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Lei Jiao
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorLijun Hu
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorYiming Zhang
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorXiangkun Jia
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorChengjie Chen
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorXiaolei Sun
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorYanling Zhai
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Zhijun Zhu
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Xiaoquan Lu
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorZirui Qin
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Lei Jiao
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorLijun Hu
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorYiming Zhang
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorXiangkun Jia
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorChengjie Chen
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorXiaolei Sun
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorYanling Zhai
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Zhijun Zhu
Institute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Xiaoquan Lu
Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education, Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Developing efficient peroxidase-like nanozymes to surpass natural enzymes remains a significant challenge. Herein, an amorphous RuO2 nanozyme with peroxidase-like activity is synthesized for activating H2O2 with a specific activity of 1492.52 U mg−1, outperforming the crystalline RuO2 nanozymes by a factor of 22 and far superior to natural peroxidases. Amorphous RuO2 nanozymes with long-range disordered atomic arrangements can effectively elongate the O─O bonds in H2O2. Abundant oxygen vacancies in amorphous RuO2 nanozymes lead to an upshift of the d-band center, enhancing the exceptional adsorption strength of H2O2, which improve the electron transfer efficiency and ensure superior peroxidase-like activity. Accordingly, a nanozyme-linked immunosorbent assay is developed for the precise and sensitive detection of prostate-specific antigens with a detection limit as low as 0.52 pg mL−1. This study introduces a simple approach for developing high-performance peroxidase-like nanozymes to improve the analytical performances of prostate-specific antigens in clinical diagnostics.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
Supporting Information
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| smll202502158-sup-0001-SuppMat.docx1,009.1 KB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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