Wearable SERS-Microfluidic Patch for Real-Time in Situ Monitoring of Chiral Metabolites in Sweat
Shuang-Feng Pan
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorCorresponding Author
Xiang-Dong Tian
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorYing Lu
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorYu-Qin Liao
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorMei-Qing Liu
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
Search for more papers by this authorLing-Yi Meng
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
Search for more papers by this authorCorresponding Author
Lei Zhou
State Key Laboratory of Biopharmaceutical Preparation and Delivery, PLA Key Laboratory of Biopharmaceutical Production & Formulation Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yun Zhang
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorShuang-Feng Pan
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorCorresponding Author
Xiang-Dong Tian
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorYing Lu
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorYu-Qin Liao
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
Search for more papers by this authorMei-Qing Liu
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
Search for more papers by this authorLing-Yi Meng
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
Search for more papers by this authorCorresponding Author
Lei Zhou
State Key Laboratory of Biopharmaceutical Preparation and Delivery, PLA Key Laboratory of Biopharmaceutical Production & Formulation Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350025 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Yun Zhang
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002 P. R. China
Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Small chiral metabolic molecules are increasingly recognized as pivotal biomarkers for disease monitoring and treatment. Here, a wearable microfluidic patch is presented that integrates chiral 3D plasmonic nanostructures with surface-enhanced Raman spectroscopy (SERS) sensing activity for the in situ and real-time metabolic profiling of chiral molecules in sweat. The microfluidic patch is designed for the direct, in situ capture and storage of microliter volumes of sweat. By exploiting the 3D chiral plasmonic coupling interactions within the nanostructures, the integrated SERS sensor on the patch allows for highly sensitive and quantitative enantiomer detection through their unique fingerprint SERS spectra. In a proof-of-concept demonstration, the first in situ, real-time quantitative detection of chiral drug metabolite and pH in human sweat using this device is successfully conducted. This capability enables the capturing of an individual's dynamic metabolic profile. Leveraging this solution, pharmacokinetic correlations are established, showcasing the potential application of the device in assessing human health.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
Research data are not shared.
Supporting Information
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| smll202500770-sup-0001-SuppMat.docx8.7 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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