A Paradigm Shift: From Batch Processing to Flow Chemistry
Kallum Hiten Mehta
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Singapore, 138634 Republic of Singapore
Search for more papers by this authorRiko I Made
Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Singapore, 138634 Republic of Singapore
Search for more papers by this authorIvan P. Parkin
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Search for more papers by this authorGopinathan Sankar
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Search for more papers by this authorCorresponding Author
Albertus Denny Handoko
Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), A*STAR, 1 Pesek Rd, Singapore, 627833 Republic of Singapore
E-mail: [email protected]
Search for more papers by this authorKallum Hiten Mehta
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Singapore, 138634 Republic of Singapore
Search for more papers by this authorRiko I Made
Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, Singapore, 138634 Republic of Singapore
Search for more papers by this authorIvan P. Parkin
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Search for more papers by this authorGopinathan Sankar
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ UK
Search for more papers by this authorCorresponding Author
Albertus Denny Handoko
Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), A*STAR, 1 Pesek Rd, Singapore, 627833 Republic of Singapore
E-mail: [email protected]
Search for more papers by this authorAbstract
Customisable flow chemistry reactors are becoming more affordable and accessible to wider research community. Coupled with rapidly advancing machine learning (ML) optimisation algorithms, time consuming research activities like catalyst discovery, reaction screening and optimisation can now be achievable quicker in flow, placing us in an interesting crossroad: should we start thinking about flow integration earlier in the research phase? In this perspective, parallels and differences between batch and flow heterogeneous catalytic reaction optimisations will be discussed with practical examples. Challenges in flow and batch processing are compared, combined with fresh perspectives of how reaction conditions can be adjusted more flexibly in multi-pass flow setting. Finally, recent progress of integrating computational techniques into flow process optimisation of contemporary “chemical looping” and paired reactions for more sustainable chemical productions will also be discussed.
Conflict of Interest
The authors declare no conflict of interest.
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