A Fused Membrane-Camouflaged Biomimetic Nanosystem for Dual-Targeted Therapy of Septic Arthritis
Correction(s) for this article
-
Correction to “A Fused Membrane-Camouflaged Biomimetic Nanosystem for Dual-Targeted Therapy of Septic Arthritis”
- Zeping Yu,
- Mengxian Wang,
- Junqiao Li,
- Hong Xu,
- Wenli Zhang,
- Fei Xing,
- Jian Li,
- Jiaojiao Yang,
- Yan Xiong,
- Small
- First Published online: July 9, 2025
Zeping Yu
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorMengxian Wang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorJunqiao Li
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorHong Xu
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorWenli Zhang
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorFei Xing
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Jian Li
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorCorresponding Author
Jiaojiao Yang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorCorresponding Author
Yan Xiong
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorZeping Yu
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorMengxian Wang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorJunqiao Li
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorHong Xu
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorWenli Zhang
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorFei Xing
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Jian Li
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorCorresponding Author
Jiaojiao Yang
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorCorresponding Author
Yan Xiong
Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041 China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, 610041 China
E-mail: [email protected] (Yan Xiong), [email protected] (Jian Li), [email protected] (Jiaojiao Yang)
Search for more papers by this authorAbstract
Due to the inherent aseptic and enclosed characteristics of joint cavity, septic arthritis (SA) almost inevitably leads to intractable infections and rapidly progressing complex pathological environments. Presently, SA faces not only the deficient effectiveness of the gold-standard systemic antibiotic therapy but also the scarcity of effective localized targeted approaches and standardized animal models. Herein, an ingenious multifunctional nanosystem is designed, which involves the methylation of hyaluronic acid (HA), copolymerization with DEGDA, loading with vancomycin (VAN), and then coating with fused macrophage-platelet membrane (denoted as FM@HA@VAN). Upon intra-articular administration, FM@HA@VAN nanoparticles exhibit sustained retention and selectively targeting to infected sites, leveraging macrophage-mediated inflammation homing and platelet-directed bacteria targeting. The acidic microenvironment triggers responsive release of vancomycin, leading to potent bactericidal effects. Subsequently, the exposed HA@VAN nanoparticles are efficiently internalized by activated macrophages, releasing HA to alleviate oxidative stress and achieve chondroprotection by inhibiting pro-inflammatory cytokines, neutralizing ROS and upregulating macrophage M2 polarization. In vivo model and experiments confirm the efficacy of this dual-targeting antibacterial approach, demonstrating its precision in eradicating bacterial infections and alleviating associated pathological processes, including synovial hyperplasia and cartilage erosion. The dual-targeting therapeutic nanosystem, coordinated with fused-membranes, holds promise for enhancing the treatment efficacy of SA.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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