NIR/MRI-Guided Oxygen-Independent Carrier-Free Anti-Tumor Nano-Theranostics
Di Gao
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorYupeng Shi
Henan Key laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 P. R. China
Search for more papers by this authorJiahua Ni
School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138 USA
Search for more papers by this authorShuojia Chen
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorYing Wang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorBin Zhao
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Department of Epidemiology, Shaanxi Provincial Tumor Hospital, Xi'an, 710061 P. R. China
Search for more papers by this authorManli Song
Henan Key laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 P. R. China
Search for more papers by this authorXiaoqing Guo
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorXuechun Ren
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorCorresponding Author
Xingcai Zhang
School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138 USA
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhongmin Tian
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhe Yang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Research Center of Life Science, Research Institute of Xi'an Jiaotong University, Zhejiang, 311200 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorDi Gao
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorYupeng Shi
Henan Key laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 P. R. China
Search for more papers by this authorJiahua Ni
School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138 USA
Search for more papers by this authorShuojia Chen
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorYing Wang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorBin Zhao
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Department of Epidemiology, Shaanxi Provincial Tumor Hospital, Xi'an, 710061 P. R. China
Search for more papers by this authorManli Song
Henan Key laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000 P. R. China
Search for more papers by this authorXiaoqing Guo
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorXuechun Ren
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Search for more papers by this authorCorresponding Author
Xingcai Zhang
School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139 USA
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138 USA
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhongmin Tian
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhe Yang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China
Research Center of Life Science, Research Institute of Xi'an Jiaotong University, Zhejiang, 311200 P. R. China
E-mail: [email protected]; [email protected]; [email protected]
Search for more papers by this authorAbstract
Imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) for cancer treatment are beneficial for precise localization of the malignant lesions and combination of multiple cell killing mechanisms in eradicating stubborn thermal-resistant cancer cells. However, overcoming the adverse impact of tumor hypoxia on PDT efficacy remains a challenge. Here, carrier-free nano-theranostic agents are developed (AIBME@IR780-APM NPs) for magnetic resonance imaging (MRI)-guided synergistic PTT/thermodynamic therapy (TDT). Two IR780 derivatives are synthesized as the subject of nanomedicine to confer the advantages for the nanomedicine, which are by feat of amphiphilic IR780-PEG to enhance the sterical stability and reduce the risk from reticuloendothelial system uptake, and IR780-ATU to chelate Mn2+ for T1-weighted MRI. Dimethyl 2,2′-azobis(2-methylpropionate) (AIBME), acting as thermally decomposable radical initiators, are further introduced into nanosystems with the purpose of generating highly cytotoxic alkyl radicals upon PTT launched by IR780 under 808 nm laser irradiation. Therefore, the sequentially generated heat and alkyl radicals synergistically induce cell death via synergistic PTT/TDT, ignoring tumor hypoxia. Moreover, these carrier-free nano-theranostic agents present satisfactory biocompatibility, which could be employed as a powerful weapon to hit hypoxic tumors via MRI-guided oxygen-independent PTT and photonic TDT.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
Data available in the article and the supplementary material as well as by reasonable request from the authors.
Supporting Information
| Filename | Description |
|---|---|
| smll202106000-sup-0001-SuppMat.pdf3.2 MB | Supporting information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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