The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV-6 Z29 strain and Molt-3 cells. The cytotoxic (IC₅₀) and the antiviral (ED₅₀) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV-6 replication. Copyright © 2002 John Wiley & Sons, Ltd.

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Volume16, Issue2

March 2002

Pages 154-156

In vitro Inhibition of HHV-6 replication by sophocarpines

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In vitro Inhibition of HHV-6 replication by sophocarpines

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