Granulomatous pleuritis caused by histoplasmosis in a healthy child
Corresponding Author
Matt Zahn MD
Division of Pediatric Infectious Diseases, University of Louisville, Louisville, Kentucky
Louisville Metro Department of Public Health and Wellness, 400 East Gray Street, Louisville, KY 40202.Search for more papers by this authorMichael Hesson MD
Department of Pediatrics, University of Louisville, Louisville, Kentucky
Search for more papers by this authorRonald Morton MD
Division of Pediatric Pulmonology, University of Louisville, Louisville, Kentucky
Search for more papers by this authorL. Joseph Wheat MD
MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana
Search for more papers by this authorCorresponding Author
Matt Zahn MD
Division of Pediatric Infectious Diseases, University of Louisville, Louisville, Kentucky
Louisville Metro Department of Public Health and Wellness, 400 East Gray Street, Louisville, KY 40202.Search for more papers by this authorMichael Hesson MD
Department of Pediatrics, University of Louisville, Louisville, Kentucky
Search for more papers by this authorRonald Morton MD
Division of Pediatric Pulmonology, University of Louisville, Louisville, Kentucky
Search for more papers by this authorL. Joseph Wheat MD
MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana
Search for more papers by this authorAbstract
Pneumonia with pleuritis is a rare presentation of histoplasmosis infection. We present a 12-year old previously healthy boy in whom histoplasmosis presented with pleuritis, confirmed by detection of antigen in empyema fluid. Pediatr. Pulmonol. 2011; 46:729–731. © 2011 Wiley-Liss, Inc.
REFERENCES
- 1 Chu JH, Feudtner C, Heydon K, Walsh TJ, Zaoutis TE. Hospitalizations for endemic mycoses: a population-based national study. Clin Inf Dis 2006; 42: 822–825.
- 2 Wheat LJ, Slama TG, Eitzen HE. A large urban outbreak of histoplasmosis: clinical features. Ann Intern Med 1981; 94: 331–337.
- 3 Richardson J, George RB. Bronchopleural fistula and lymphocytic empyema due to Histoplasma capsulatum . Chest 1997; 112(4): 1130–1132.
- 4 George RB. Mycobacterial, fungal, actinomycotic and nocardial infections of the pleura. Clin Chest Med 1985; 6: 63–75.
- 5 Merry CM, Bufo AJ, Shah RS, Schropp KP, Lobe TE. Early definitive intervention by thoracoscopy in pediatric empyema. J Pediatr Surg 1999; 34(1): 178–180.
- 6 Brewer PL, Himmelwright JP. Pleural effusion due to infection with Histoplasma capsulatum . Chest 1970; 58: 76–79.
- 7 Polk JW. Surgery for pulmonary histoplasmosis. In: HC Sweany, editor. Histoplasmosis. Springfield, IL: CC Thomas; 1960. p. 472.
- 8 Newsome BD, Hardy JD. Pulmonary fungal infections. J Thor Card Surg 1982; 83: 218–226.
- 9 Johns LE, Garrison RG, White TG. Bronchopleurocutaneous fistula due to infection with Histoplasma capsulatum . Chest 1973; 63(4): 638–641.
- 10 Wheat LJ. Current diagnosis of histoplasmosis. Trends Microbiol 2003; 11(10): 489–494.
- 11 Durkin MM, Connolly PA, Wheat LJ. Comparison of radioimmunoassay and enzyme-linked immunoassay methods for detection of Histoplasma capsulatum var. capsulatum antigen. J Clin Microbiol 1997; 35(9): 2252–2255.
- 12 Wheat LJ, Witt J III, Durkin M, Connolly P. Reduction in false antigenemia in the second generation histoplasma antigen assay. Med Mycol 2007; 45(2): 169–171.
- 13 Wheat LJ, Connolly P, Durkin M, Book BK, Pescovitz MD. Elimination of false-positive histoplasma antigenemia caused by human anti-rabbit antibodies in the second-generation histoplasma antigen assay. Transpl Infect Dis 2006; 8(4): 219–221.
- 14 Connolly PA, Durkin MM, Lemonte AM, Hackett EJ, Wheat LJ. Detection of histoplasma antigen by a quantitative enzyme immunoassay. Clin Vaccine Immunol 2007; 14(12): 1587–1591.
- 15 Hage CA, Bowyer S, Tarvin SE, Helper D, Kleiman MB, Wheat LJ. Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. Clin Infect Dis 2010; 50(1): 85–92.
- 16 Hage CA, Davis TE, Fuller D, Egan L, Witt JR III, Wheat LJ, Knox KS. Diagnosis of histoplasmosis by antigen detection in bronchoalveolar fluid. Chest 2010; 137(3): 623–628.
- 17 Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA. Clinical practice guidelines for the management of patients with histoplasmosis: 2007. Update by the Infectious Diseases Society of America. Clin Inf Dis 2007; 45: 807–825.
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